{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T05:07:28Z","timestamp":1780636048479,"version":"3.54.1"},"reference-count":35,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T00:00:00Z","timestamp":1759795200000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100010564","name":"Academic Medical Organization of Southwestern Ontario","doi-asserted-by":"publisher","award":["F20\u2010004"],"award-info":[{"award-number":["F20\u2010004"]}],"id":[{"id":"10.13039\/100010564","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["A&amp;amp;D Transl Res &amp;amp; Clin Interv"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>We tested the hypothesis that increased middle cerebral artery velocity (MCA velocity) during complex motor (overground walking) and cognitive tasks (e.g., dual task) is associated with cognitive performance in older adults with varying levels of cognitive ability.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>Fifty\u2010six participants (19 females, 75 \u00b1 7 years old) completed a seated single task that assessed working memory performance; a walking single task, assessing overground walking gait speed; and a dual task, combining both. Continuous MCA velocity was collected, and participants completed a Montreal Cognitive Assessment (MoCA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Higher MCA velocity was associated with faster gait speed, better working memory performance, and greater MoCA scores (all\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.05). Participants with lower MoCA scores had lower MCA velocity (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.052), slower gait speed (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.035), and lower working memory performance (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.016) than people with higher MoCA scores. The hyperemic response of MCA velocity from single task walking to the dual task with increased cognitive load significantly contributed to MoCA scores (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.017).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>The functional response of cerebral blood flow with these tests suggests vascular properties may be considered a biomarker indicative of subclinical cognitive function during walking tasks.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>Mobile devices simultaneously assessed neurovascular coupling and dual\u2010task cost.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Middle cerebral artery velocity (MCA velocity) is negatively associated with dual\u2010task cost.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>MCA velocity is associated with gait speed, working memory, and Montreal Cognitive Assessment scores.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>MCA velocity decreased from controls to mild cognitive impairment to dementia.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Novel methodological approach to utilize MCA velocity during overground walking, single\u2010tasks, and dual\u2010tasks.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/trc2.70156","type":"journal-article","created":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T03:25:25Z","timestamp":1759893925000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Neurovascular de\u2010coupling underlies dual\u2010task cost across cognitive abilities"],"prefix":"10.1002","volume":"11","author":[{"given":"Laura K.","family":"Fitzgibbon\u2010Collins","sequence":"first","affiliation":[{"name":"Department of Medicine Division of Geriatric Medicine Schulich School of Medicine &amp; Dentistry University of Western Ontario  London Ontario Canada"},{"name":"Department of Kinesiology University of Western Ontario  London Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Best","sequence":"additional","affiliation":[{"name":"Cognitive Clinical Research Group Parkwood Institute  London Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mamiko","family":"Noguchi","sequence":"additional","affiliation":[{"name":"Department of Kinesiology University of Waterloo  Waterloo Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corey","family":"Guest","sequence":"additional","affiliation":[{"name":"Department of Medicine Division of Geriatric Medicine Schulich School of Medicine &amp; Dentistry University of Western Ontario  London Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Borrie","sequence":"additional","affiliation":[{"name":"Department of Medicine Division of Geriatric Medicine Schulich School of Medicine &amp; Dentistry University of Western Ontario  London Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Kevin","family":"Shoemaker","sequence":"additional","affiliation":[{"name":"Department of Kinesiology University of Western Ontario  London Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaspreet","family":"Bhangu","sequence":"additional","affiliation":[{"name":"Department of Medicine Division of Geriatric Medicine Schulich School of Medicine &amp; Dentistry University of Western Ontario  London Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,7]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glx063"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glr068"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/GERONA\/GLZ006"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22433"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature09613"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature03690"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2017.07.030"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12868\u2010018\u20100465\u20105"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2020.11.003"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12298"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2014.01.001"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11682\u2010016\u20109508\u20107"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.3758\/BF03195736"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2666\u20107568(23)00009\u20100"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11307\u2010006\u20100066\u2010z"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1002261"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12993\u2010015\u20100073\u20109"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2017.0643"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/gls256"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glv066"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2010.159"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bandc.2017.04.002"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cccb.2023.100198"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1177\/0271678\u00d7251345361"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2011.12.002"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.15158"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/657508"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/3589271"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.14283\/jpad.2024.16"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195\u2010024\u201001406\u2010x"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13293\u2010022\u201000431\u20105"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12916\u2010014\u20100130\u20105"},{"key":"e_1_2_9_34_1","unstructured":"World Health Organization.Risk reduction of cognitive decline and dementia WHO guidelines. 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