{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T22:21:30Z","timestamp":1791411690942,"version":"4.3.3"},"reference-count":44,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T00:00:00Z","timestamp":1762128000000},"content-version":"vor","delay-in-days":33,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004896","name":"Eisai Incorporated","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004896","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["A&amp;amp;D Transl Res &amp;amp; Clin Interv"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>Alzheimer's disease (AD) is often underdiagnosed, especially at early stages when symptoms are mild, and patients may benefit from new and recently approved anti\u2010amyloid therapies. An updated patient care pathway may facilitate timely diagnosis and intervention. We conducted a scan of published information and convened an expert panel of health care professionals to gain insights on early AD care pathways. We developed an Early AD Patient Care Pathway as an implementation guide that includes new diagnostic and treatment modalities and addresses needs and opportunities. The Early AD Patient Care Pathway focuses on patient identification, assessment, diagnosis, treatment, and management and monitoring. Operational readiness considerations aid pathway implementation and include evaluating and addressing gaps in program and business planning, technology, education and resources, access and reimbursement, and care coordination. The pathway is adaptable to health system needs and may be further tested and refined for sustainability.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>We analyzed published information and insights from subject matter experts on care pathways for early Alzheimer's disease.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>We identified opportunities to improve screening of at\u2010risk patients, make appropriate specialist referrals, and ensure timely access and care coordination for diagnosis, treatment, and monitoring as a means of incorporating the latest diagnostics and therapy options.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>We developed a care pathway that promotes an integrated approach to patient care and is adaptable to various healthcare settings with input from subject matter experts.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/trc2.70162","type":"journal-article","created":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T10:44:57Z","timestamp":1762166697000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Early Alzheimer's disease patient care pathway and health system readiness: A framework for integrated care"],"prefix":"10.1002","volume":"11","author":[{"given":"Ilya M.","family":"Nasrallah","sequence":"first","affiliation":[{"name":"Department of Radiology University of Pennsylvania Hospital  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7352-9325","authenticated-orcid":false,"given":"Cate","family":"Polacek","sequence":"additional","affiliation":[{"name":"Applied Sciences Premier Inc.  Charlotte North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feride H.","family":"Frech","sequence":"additional","affiliation":[{"name":"US Neurology Medical Affairs Eisai Inc.  Nutley New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre N.","family":"Tariot","sequence":"additional","affiliation":[{"name":"Banner Alzheimer's Institute University of Arizona College of Medicine  Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeff","family":"Vawter","sequence":"additional","affiliation":[{"name":"Applied Sciences Premier Inc.  Charlotte North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuval","family":"Zabar","sequence":"additional","affiliation":[{"name":"Global Medical Affairs Biogen Inc.  Cambridge Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Divers","sequence":"additional","affiliation":[{"name":"US Neurology Medical Affairs Eisai Inc.  Nutley New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Whoy Y","family":"Shang","sequence":"additional","affiliation":[{"name":"Department of Geriatrics Norton Healthcare  Louisville Kentucky USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David S.","family":"Geldmacher","sequence":"additional","affiliation":[{"name":"Callahan Eye Hospital University of Alabama at Birmingham  Birmingham Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Towman","sequence":"additional","affiliation":[{"name":"US Neurology Medical Affairs Eisai Inc.  Nutley New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather","family":"Reiter","sequence":"additional","affiliation":[{"name":"Applied Sciences Premier Inc.  Charlotte North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cindy D.","family":"Marshall","sequence":"additional","affiliation":[{"name":"AT&amp;T Memory Center Baylor Scott &amp; White Health  Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"Baldivieso","sequence":"additional","affiliation":[{"name":"Medical Group Memory Care at Innovation Tower AdventHealth  Orlando Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daryl Rhys","family":"Jones","sequence":"additional","affiliation":[{"name":"US Neurology Medical Affairs Eisai Inc.  Nutley New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik S.","family":"Musiek","sequence":"additional","affiliation":[{"name":"Department of Neurology Washington University  St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideki","family":"Toyosaki","sequence":"additional","affiliation":[{"name":"US Neurology Medical Affairs Eisai Inc.  Nutley New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Babak","family":"Tousi","sequence":"additional","affiliation":[{"name":"Lou Ruvo Center for Brain Health Cleveland Clinic  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,3]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"Alzheimer's Association.Alzheimer's Disease Facts and Figures.2024. Accessed July 25 2024.https:\/\/www.alz.org\/media\/documents\/alzheimers\u2010facts\u2010and\u2010figures.pdf"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12362"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002093\u2010200110000\u201000002"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glab043"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/dad2.12497"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11606\u2010021\u201007169\u20107"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1159\/000354370"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2023.13239"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2212948"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/1179573520907397"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43587\u2010022\u201000269\u2010x"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.17345"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.37765\/ajmc.2020.88482"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12470"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.2174\/1567205015666180119092427"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.3389\/frdem.2023.1271680"},{"key":"e_1_2_8_18_1","unstructured":"BriesacherB ZhangN JudayTR FrechFH BatrlaR.Impact of a Timely Diagnosis of Early Alzheimer's Disease on Functional Outcomes. presented at:Alzheimer's Association International Conference Annual Meeting;2024;Philadelphia PA."},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/23337214231213185"},{"key":"e_1_2_8_20_1","unstructured":"Alzheimer's Association.Comprehensive care for Alzheimer's act.2023. 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