{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T05:59:38Z","timestamp":1780639178252,"version":"3.54.1"},"reference-count":36,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T00:00:00Z","timestamp":1766102400000},"content-version":"vor","delay-in-days":79,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP24dk0207069"],"award-info":[{"award-number":["JP24dk0207069"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP23dk0207048"],"award-info":[{"award-number":["JP23dk0207048"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP23dk0207054"],"award-info":[{"award-number":["JP23dk0207054"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["A&amp;amp;D Transl Res &amp;amp; Clin Interv"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>Amyloid positron emission tomography (PET) has become increasingly important for detection of early Alzheimer's disease (AD) and eligibility for emerging disease\u2010modifying therapies. While North American and European studies report limited short\u2010term psychological harm following disclosure of amyloid status in asymptomatic individuals, evidence in non\u2010North American and European contexts is scarce. We evaluated the immediate psychological impact of amyloid PET disclosure in a large Japanese cohort without dementia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>We analyzed data from 630 cognitively unimpaired Clinical Dementia Rating global score (CDR\u2010GS of 0, 70%) or mild cognitive impairment (CDR\u2010GS of 0.5, 30%) participants 50\u201385 years of age enrolled in the Japanese Trial\u2010Ready Cohort onsite study across seven centers between July 2020 and January 2024. Amyloid PET positivity was defined by visual read or Centiloid \u226512. Psychological outcomes\u2014Future Time Perspective (FTP), and Concerns about AD\u2014were assessed immediately before and after disclosure; Impact of Event Scale (IES) was also measured via telephone 1\u20133 days post\u2010disclosure. Mixed\u2010effects Poisson and linear regression models, adjusted for site, participant, and baseline covariates, evaluated the effects of PET positivity on post\u2010disclosure outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Twenty\u2010six percent of participants were PET positive. PET\u2010positive individuals experienced greater distress (median IES 8\u00a0vs 3) compared with PET\u2010negative peers, whereas FTP improved similarly irrespective of PET status. Concerns about AD increased modestly in PET\u2010positive participants (+4.8%) but decreased in PET\u2010negative individuals (\u22125.5%; interaction\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001). Female sex and higher baseline depression and anxiety predicted larger distress responses.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Consistent with North American and European findings, amyloid PET disclosure in this Japanese cohort was generally well\u2010tolerated, eliciting only modest increases in distress and concerns among PET\u2010positive individuals. These results support the feasibility and ethical acceptability of structured disclosure protocols across cultural settings and highlight the importance of tailored counseling for at\u2010risk subgroups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>Immediate impact of amyloid disclosure in a Japanese cohort without dementia.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Amyloid\u2010positive individuals had higher distress (Impact of Event Scale) after disclosure.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Future Time Perspective improved similarly regardless of amyloid positron emission tomography (PET) results.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Concerns about Alzheimer's disease slightly rose in PET\u2010positive participants.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Female sex and higher baseline depression and anxiety predicted larger distress.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/trc2.70167","type":"journal-article","created":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T11:16:39Z","timestamp":1766142999000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Immediate reactions to amyloid PET disclosure in Japanese older adults without dementia"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4351-9526","authenticated-orcid":false,"given":"Kenichiro","family":"Sato","sequence":"first","affiliation":[{"name":"Department of Neuropathology Graduate School of Medicine The University of Tokyo  Tokyo Japan"},{"name":"Unit for Early and Exploratory Clinical Development The University of Tokyo Hospital  Tokyo Japan"},{"name":"Dementia Inclusion and Therapeutics The University of Tokyo Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2556-8167","authenticated-orcid":false,"given":"Yoshiki","family":"Niimi","sequence":"additional","affiliation":[{"name":"Unit for Early and Exploratory Clinical Development The University of Tokyo Hospital  Tokyo Japan"},{"name":"Dementia Inclusion and Therapeutics The University of Tokyo Hospital  Tokyo 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Obu\u2010shi Aichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Iwata","sequence":"additional","affiliation":[{"name":"Department of Neurology Tokyo Metropolitan Institute for Geriatrics and Gerontology  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kensaku","family":"Kasuga","sequence":"additional","affiliation":[{"name":"Department of Molecular Genetics Brain Research Institute Niigata University  Niigata\u2010shi Japan"},{"name":"Department of Diagnostic Innovation Science National Center for Geriatrics and Gerontology  Obu\u2010shi Aichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Kato","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Neuroimaging National Center for Geriatrics and Gerontology  Obu\u2010shi Aichi 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