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Identifying risk profiles can inform prevention strategies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>This study examined profiles using seven modifiable risk factors and their associations with cognition and sex among older adults at risk of dementia. Risk profiles were identified using principal component analysis, and linear regressions assessed their associations with cognition.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Three profiles emerged: (1) better sleep and social\/psychological health; (2) better diet, physical activity, and vascular health; and (3) better cognitive engagement. Similar profiles were observed in women, except that better cognitive engagement grouped with poorer vascular health. In men, better cognitive engagement grouped with better vascular health and vision\/hearing, while lower cognitive engagement was grouped with better sleep and social\/psychological health. The lower cognitive engagement profile in men was associated with poorer cognition.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Prevention strategies should target meaningful combinations of risk factors to improve dementia prevention. Further research is needed to validate and refine these profiles.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>This study evaluated risk profiles using a broad range of modifiable risk factors.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>This is the first study to analyze such profiles in a Canadian population, stratified by sex.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Risk profiles differed by sex, especially for the cognitive engagement risk factor.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>In men, lower cognitive engagement profile was associated with poorer cognition.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/trc2.70173","type":"journal-article","created":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T03:54:58Z","timestamp":1763438098000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Risk factor profiles and cognitive function in older adults: the Brain Health Support Program Study"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3716-1911","authenticated-orcid":false,"given":"Caroline S.","family":"Duchaine","sequence":"first","affiliation":[{"name":"Centre de recherche de l'Institut universitaire de g\u00e9riatrie de Montr\u00e9al (CRIUGM)  Montr\u00e9al Qu\u00e9bec Canada"},{"name":"Centre de recherche du CISSS de Chaudi\u00e8re\u2010Appalaches  L\u00e9vis Qu\u00e9bec Canada"},{"name":"D\u00e9partement des sciences de la sant\u00e9 Universit\u00e9 du Qu\u00e9bec \u00e0 Rimouski  L\u00e9vis Qu\u00e9bec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Montero\u2010Odasso","sequence":"additional","affiliation":[{"name":"Gait and Brain Laboratory, Lawson Health Research Institute, Parkwood Institute  London Ontario Canada"},{"name":"Department of Medicine (Geriatrics) Schulich School of Medicine and Dentistry University of Western Ontario  London Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haakon B.","family":"Nygaard","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Neurology University of British Colombia  Vancouver British Colombia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul W. 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