{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T14:07:06Z","timestamp":1791382026584,"version":"4.3.3"},"reference-count":46,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T00:00:00Z","timestamp":1766102400000},"content-version":"vor","delay-in-days":79,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["A&amp;amp;D Transl Res &amp;amp; Clin Interv"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>Timely and accurate diagnosis of early Alzheimer's disease (AD) is critical to maximizing the potential benefits of disease\u2010modifying therapies; however, it remains a challenge in clinical practice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      A double\u2010blind survey was conducted among general practitioners (GPs;\n                      <jats:italic>n<\/jats:italic>\n                      = 52) and AD specialists (neurologists, psychiatrists, geriatricians, and others;\n                      <jats:italic>n<\/jats:italic>\n                      = 75) across five European countries to evaluate healthcare practitioners\u2019 (HCPs) perceptions of diagnosing AD. Data from all countries were pooled and presented overall.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>GPs are usually the first point of contact for patients with mild cognitive impairment (MCI)\/AD. Only 30% of patients received a formal diagnosis of AD during the MCI stage, and it took patients 15.2 months from symptom onset to their first primary care visit. The most common challenges identified by HCPs were referral times, lack of effective treatment, and resource and time constraints.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Systemic reforms are required to remove barriers in early AD diagnosis, including tailored training and coordinated care between GPs and AD specialists.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>Timely diagnosis of eAD remains a major challenge in clinical practice.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Only one\u2010third of patients received a formal diagnosis of AD during the MCI stage.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>It took patients 15.2 months from symptom onset to first primary care visit.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Key diagnostic barriers include referral delays and lack of effective treatments.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Addressing these issues may improve eAD diagnosis and timely intervention.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/trc2.70178","type":"journal-article","created":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T11:06:24Z","timestamp":1766142384000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Uncovering barriers to early diagnosis of Alzheimer's disease: a European perspective"],"prefix":"10.1002","volume":"11","author":[{"given":"David A.","family":"P\u00e9rez\u2010Mart\u00ednez","sequence":"first","affiliation":[{"name":"Head of Neurology Department Hospital Universitario 12 de Octubre  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-1770-6226","authenticated-orcid":false,"given":"Anne\u2010Charlotte","family":"Jarry","sequence":"additional","affiliation":[{"name":"Novo Nordisk  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel","family":"Martino","sequence":"additional","affiliation":[{"name":"Novo Nordisk  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giancarlo","family":"Pesce","sequence":"additional","affiliation":[{"name":"Evidence and Access Certara  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Izabela","family":"Pieniazek","sequence":"additional","affiliation":[{"name":"Evidence and Access Certara  Krakow Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenny","family":"Presto","sequence":"additional","affiliation":[{"name":"Novo Nordisk  Malm\u00f6 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patryk","family":"Miernik","sequence":"additional","affiliation":[{"name":"Evidence and Access Certara  Krakow Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roman","family":"Casciano","sequence":"additional","affiliation":[{"name":"Evidence and Access Certara  Radnor Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristian Steen","family":"Frederiksen","sequence":"additional","affiliation":[{"name":"Danish Dementia Research Centre Department of Neurology Copenhagen University Hospital \u2010 Rigshospitalet  Copenhagen Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,19]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12328"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195\u2010017\u20100283\u20105"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.13809"},{"key":"e_1_2_9_5_1","volume-title":"Global Health Estimates: Life Expectancy and Leading Causes of Death and Disability","author":"World Health Organization","year":"2021"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12694"},{"key":"e_1_2_9_7_1","volume-title":"Rethinking Alzheimer's Disease","author":"European Brain Council"},{"key":"e_1_2_9_8_1","volume-title":"Rethinking Alzheimer's Disease. 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