{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T01:29:55Z","timestamp":1792286995275,"version":"4.4.0"},"reference-count":50,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T00:00:00Z","timestamp":1765584000000},"content-version":"vor","delay-in-days":73,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["MOP\u2010126130"],"award-info":[{"award-number":["MOP\u2010126130"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["A&amp;amp;D Transl Res &amp;amp; Clin Interv"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>Having a stroke increases risk for dementia two\u2010fold. Poor sleep quality and quantity are common after a stroke and are associated with cognitive impairment. Physical activity benefits cognitive function. Whether there is an interaction effect of physical activity and sleep on cognitive function among persons living with chronic stroke is unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      A cross\u2010sectional study used baseline data acquired from 97 community\u2010dwelling adults aged \u226555 years, living with chronic stroke (71\u00b19 years;\n                      <jats:italic>n<\/jats:italic>\n                      = 38, female), and enrolled in a 6\u2010month randomized controlled trial. We measured physical activity (i.e., moderate to vigorous physical activity [MVPA] and light physical activity [PA]) and sleep quality and quantity (i.e., efficiency, latency, duration) using wrist\u2010worn accelerometry. Global cognitive function was measured with the 13\u2010item Alzheimer's Disease Assessment Scale\u2013Cognitive Subscale (ADAS\u2010Cog\u201013). We assessed whether the interaction of physical activity (MVPA and light PA) with sleep quality and quantity (interaction term: physical activity * sleep) was associated with ADAS\u2010Cog\u201013 score: (1) in the full sample and (2) among males and females separately (i.e., sex\u2010stratified). Significant moderations were plotted as continuous simple slopes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      In the full sample, there was a significant interaction effect between MVPA and sleep duration on the ADAS\u2010COG\u201013 score (\u00df = 1.636 \u00b1 0.787;\n                      <jats:italic>p<\/jats:italic>\n                      = 0.041). Specifically, among individuals with shorter sleep duration (i.e., one standard deviation below mean sleep duration), those with greater MVPA had better ADAS\u2010Cog\u201013 performance. In the sex\u2010stratified analysis, the interaction effect of MVPA and sleep duration on cognitive function was significant in males (\u00df = 3.417 \u00b1 1.374;\n                      <jats:italic>p<\/jats:italic>\n                      = 0.016) but not females.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Moderate to vigerous physical activity may mitigate the negative impact of shorter sleep on cognitive function among persons living with stroke, particularly males.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>Physical activity and sleep are associated with cognitive function following stroke.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Physical activity may ameliorate the negative effects of poor sleep on cognitive function.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Females suffer greater health consequences of sleep dysregulation than males.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Physical activity moderates the association of sleep duration and cognitive function.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Physical activity may promote cognitive function in males with short sleep duration.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/trc2.70185","type":"journal-article","created":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T10:29:14Z","timestamp":1765621754000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The interaction effect of physical activity and sleep on cognitive function in stroke"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4529-284X","authenticated-orcid":false,"given":"Ryan G.","family":"Stein","sequence":"first","affiliation":[{"name":"Aging, Mobility, and Cognitive Health Laboratory The University of British Columbia  Vancouver British Columbia Canada"},{"name":"Djavad Mowafaghian Centre for Brain Health The University of British Columbia  Vancouver British Columbia Canada"},{"name":"Centre for Aging SMART at Vancouver Coast Health Vancouver Coastal Health Research Institute Vancouver British Columbia Canada"},{"name":"Department of Physical Therapy University of British Columbia  Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan S.","family":"Falck","sequence":"additional","affiliation":[{"name":"Aging, Mobility, and Cognitive Health Laboratory The University of British Columbia  Vancouver British Columbia Canada"},{"name":"Djavad Mowafaghian Centre for Brain Health The University of British Columbia  Vancouver British Columbia Canada"},{"name":"Centre for Aging SMART at Vancouver Coast Health Vancouver Coastal Health Research Institute Vancouver British Columbia Canada"},{"name":"Department of Physical Therapy University of British Columbia  Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daria","family":"Tai","sequence":"additional","affiliation":[{"name":"Aging, Mobility, and Cognitive Health Laboratory The University of British Columbia  Vancouver British Columbia Canada"},{"name":"Djavad Mowafaghian Centre for Brain Health The University of British Columbia  Vancouver British Columbia Canada"},{"name":"Centre for Aging SMART at Vancouver Coast Health Vancouver Coastal Health Research Institute Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel A.","family":"Crockett","sequence":"additional","affiliation":[{"name":"Nuffield Department of Clinical Neurosciences University of Oxford, Headington  Oxford UK"},{"name":"Institute of Biomedical Engineering University of Oxford, Headington  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer C.","family":"Davis","sequence":"additional","affiliation":[{"name":"Djavad Mowafaghian Centre for Brain Health The University of British Columbia  Vancouver British Columbia Canada"},{"name":"Centre for Aging SMART at Vancouver Coast Health Vancouver Coastal Health Research Institute Vancouver British Columbia Canada"},{"name":"Department of Psychiatry University of British Columbia  Vancouver British Columbia Canada"},{"name":"Applied Health Economics Laboratory Faculty of Management The University of British Columbia \u2010 Okanagan  Kelowna British Columbia Canada"},{"name":"Faculty of Management University of British Columbia\u2010Okanagan Campus  Kelowna British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. 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Robin","family":"Hsiung","sequence":"additional","affiliation":[{"name":"Djavad Mowafaghian Centre for Brain Health The University of British Columbia  Vancouver British Columbia Canada"},{"name":"Division of Neurology University of British Columbia  Vancouver British Columbia Canada"},{"name":"Vancouver Coastal Health Research Institute and University of British Columbia Hospital Clinic for Alzheimer Disease and Related Disorders  Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janice J.","family":"Eng","sequence":"additional","affiliation":[{"name":"Centre for Aging SMART at Vancouver Coast Health Vancouver Coastal Health Research Institute Vancouver British Columbia Canada"},{"name":"Department of Physical Therapy University of British Columbia  Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura E.","family":"Middleton","sequence":"additional","affiliation":[{"name":"Department of Kinesiology and Health Sciences University of Waterloo  Waterloo Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter A.","family":"Hall","sequence":"additional","affiliation":[{"name":"School of Public Health Sciences Faculty of Health University of Waterloo  Waterloo Ontario Canada"},{"name":"Centre for Bioengineering and Biotechnology University of Waterloo  Waterloo Ontario Canada"},{"name":"Department of Psychology University of Waterloo  Waterloo Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Liu\u2010Ambrose","sequence":"additional","affiliation":[{"name":"Aging, Mobility, and Cognitive Health Laboratory The University of British Columbia  Vancouver British Columbia Canada"},{"name":"Djavad Mowafaghian Centre for Brain Health The University of British Columbia  Vancouver British Columbia Canada"},{"name":"Centre for Aging SMART at Vancouver Coast Health Vancouver Coastal Health Research Institute Vancouver British Columbia Canada"},{"name":"Department of Physical Therapy University of British Columbia  Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,13]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000012781"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1532-5415.2002.50165.x"},{"key":"e_1_2_9_4_1","unstructured":"Stroke and Dementia. 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