{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T00:50:49Z","timestamp":1775868649762,"version":"3.50.1"},"reference-count":41,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T00:00:00Z","timestamp":1773360000000},"content-version":"vor","delay-in-days":71,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100016954","name":"Institute on Aging, University of Pennsylvania","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016954","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["A&amp;amp;D Transl Res &amp;amp; Clin Interv"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>Blood\u2010based Alzheimer's disease (AD) biomarkers are increasingly used in clinical care, but there are few real\u2010world studies of their clinical utility. We evaluated the impact of plasma phosphorylated tau at threonine 181 (p\u2010tau181) on the diagnosis and management of patients with cognitive impairment in a memory clinic.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>Dementia specialists referred patients for plasma p\u2010tau181 testing during clinical care. We used surveys and chart review to assess the impact of plasma p\u2010tau181 testing on clinical care and patient and care partner wellbeing. We assessed co\u2010primary outcomes of (1) change in diagnostic confidence before vs after testing, (2) change in diagnosis, and (3) change in management. A diagnosis or management change of greater than 30% was considered to be clinically significant. Secondary and exploratory outcomes included impact of plasma p\u2010tau181 testing on the use of additional diagnostics and impact on patient and care partner psychological wellbeing, health behaviors, and future planning.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      One hundred patients completed plasma p\u2010tau181 testing; 81% had an elevated result, and 19% had a non\u2010elevated result. Clinician diagnostic confidence averaged 1.43 points higher after p\u2010tau181 testing (95% confidence interval [CI] 1.02 to 1.84,\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.0001). After testing, 27.7% (95% CI 18.9% to 36.4%,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.31) of patients had a change in management and 17.2% of patients had a change in diagnosis \u2013 significantly lower than the 30% threshold (95% CI 9.5% to 24.9%,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.004). Patients with elevated results were less likely to have a diagnosis changed after testing than those with non\u2010elevated results (OR 0.08 [95% CI 0.01 to 0.47],\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.005). A non\u2010elevated result was associated with decreased use of amyloid positron emission tomography (PET) (odds ratio [OR] 0.25 [95% CI 0.07 to 0.86],\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.028). Patients with an elevated result had higher anxiety at 2 to 3 months after disclosure (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.01).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Non\u2010elevated plasma p\u2010tau181 results impacted the diagnosis and use of amyloid PET imaging in a memory clinic. There was increased anxiety in patients after testing, affirming the need for post\u2010disclosure psychological support.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/trc2.70207","type":"journal-article","created":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T06:11:04Z","timestamp":1773468664000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Study of the utility and impact of a plasma p\u2010tau181 Alzheimer's biomarker (SUITABLE)"],"prefix":"10.1002","volume":"12","author":[{"given":"Kyra","family":"O'Brien","sequence":"first","affiliation":[{"name":"Department of Neurology Perelman School of Medicine University of Pennsylvania  Philadelphia Pennsylvania USA"},{"name":"Leonard Davis Institute of Health Economics University of Pennsylvania  Philadelphia Pennsylvania 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