{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T00:49:09Z","timestamp":1775868549824,"version":"3.50.1"},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T00:00:00Z","timestamp":1773014400000},"content-version":"vor","delay-in-days":67,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000957","name":"Alzheimer's Association","doi-asserted-by":"publisher","award":["AARF\u2010D\u201024\u20101243696"],"award-info":[{"award-number":["AARF\u2010D\u201024\u20101243696"]}],"id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000861","name":"Burroughs Wellcome Fund","doi-asserted-by":"publisher","award":["24\u201041"],"award-info":[{"award-number":["24\u201041"]}],"id":[{"id":"10.13039\/100000861","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["U19AG024904"],"award-info":[{"award-number":["U19AG024904"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["A&amp;D Transl Res &amp; Clin Interv"],"published-print":{"date-parts":[[2026,1]]},"abstract":"Abstract<\/jats:title>\n \n INTRODUCTION<\/jats:title>\n It remains unclear whether specific blood pressure components\u2014systolic blood pressure (SBP), diastolic blood pressure (DBP), pulse pressure (PP), or mean arterial pressure (MAP)\u2014are similarly associated with white matter hyperintensity (WMH) burden across sexes within racial and ethnic groups.<\/jats:p>\n <\/jats:sec>\n \n METHODS<\/jats:title>\n \n Participants were drawn from the Health and Aging Brain Study\u2014Health Disparities (HABS\u2010HD) and included non\u2010Hispanic White (NHW;\n n<\/jats:italic>\n = 1318), non\u2010Hispanic Black (NHB;\n n<\/jats:italic>\n = 1009), and Hispanic (\n n<\/jats:italic>\n = 1307) adults. Linear regression models examined associations between SBP, DBP, PP, and MAP with log\u2010transformed WMH volume normalized to intracranial volume. Analyses were stratified by race and ethnic group and included sex \u00d7 blood pressure interaction terms. Models adjusted for age, education, neuroimaging scanner, diabetes, dyslipidemia, obesity, and tobacco use.\n <\/jats:p>\n <\/jats:sec>\n \n RESULTS<\/jats:title>\n Among NHW participants, higher SBP and PP were more strongly associated with greater WMH volume in females compared to males. Among NHB participants, blood pressure\u2013WMH associations did not differ by sex. Among Hispanic participants, females exhibited greater WMH volume in DBP\u2010 and MAP\u2010adjusted models, although blood pressure\u2013WMH associations were stronger in males.<\/jats:p>\n <\/jats:sec>\n \n DISCUSSION<\/jats:title>\n Blood pressure\u2013WMH associations differ by sex within racial and ethnic groups. These findings highlight intersectional heterogeneity in cerebrovascular vulnerability and suggest that sex\u2010specific blood pressure\u2013related pathways to small\u2010vessel injury vary across racial and ethnic contexts.<\/jats:p>\n <\/jats:sec>\n \n Highlights<\/jats:title>\n \n \n \n Non\u2010Hispanic White (NHW) females showed stronger systolic blood pressure (SBP)\u2010 and pulse pressure (PP)\u2013white matter hyperintensity (WMH) associations than NHW males.<\/jats:p>\n <\/jats:list-item>\n \n Blood pressure (BP)\u2013WMH associations did not differ by sex among non\u2010Hispanic Black participants.<\/jats:p>\n <\/jats:list-item>\n \n Among Hispanic adults, BP\u2013WMH associations were stronger in males than females.<\/jats:p>\n <\/jats:list-item>\n \n Antihypertensive use was associated with higher WMHs across race and ethnic groups.<\/jats:p>\n <\/jats:list-item>\n \n BP\u2010related WMH vulnerability varies by sex and race and ethnic context.<\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/trc2.70214","type":"journal-article","created":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T03:06:29Z","timestamp":1773111989000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Sex differences in blood pressure hemodynamics and white matter hyperintensity volume across racial ethnic groups\u2014HABS\u2010HD"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6259-9456","authenticated-orcid":false,"given":"Cellas A.","family":"Hayes","sequence":"first","affiliation":[{"name":"Stanford University School of Medicine Department of Epidemiology and Population Health Palo Alto California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9459-5214","authenticated-orcid":false,"given":"Anthony 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