{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T21:36:26Z","timestamp":1782250586981,"version":"3.54.5"},"reference-count":43,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T00:00:00Z","timestamp":1770768000000},"content-version":"vor","delay-in-days":41,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["A&amp;amp;D Transl Res &amp;amp; Clin Interv"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>Multidomain lifestyle\u2010based interventions seem to be effective for cognitive improvement but larger trials are limited, especially in China. This study aims to explore whether multi\u2010domain interventions of Baduanjin exercise, the Mediterranean\u2010DASH Intervention for Neurodegenerative Delay (MIND) diet, and relaxation training can improve cognitive function in older adults.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>This is a four\u2010arm cluster randomized trial conducted in 15 centers (counties\/districts) in China. A total of 60 communities with 886 older adults with cognitive impairment were randomized to the control group (routine service, RS), and groups B (Baduanjin exercise, plus RS), BM (Baduanjin exercise and MIND diet, plus RS), and BMR (Baduanjin exercise, MIND diet, and relaxation training, plus RS), in a 1:1:1:1 ratio. The intervention lasted for 9 months. The two primary outcomes were an executive function composite and a global cognitive function composite; the secondary outcomes were Mini\u2010Mental State Examination (MMSE) score and six individual tests that comprise the global cognitive function composite.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Among 886 old adults with cognitive impairment at baseline, 801 and 809 participants were followed for 4.5 months and 9 months, respectively. At the 9\u2010month follow\u2010up, the BMR and BM interventions showed significant effects on executive function (Mean difference in change of composite for BMR vs. Control: 0.26 points [95% CI, 0.11, 0.41],\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001; BM vs. Control: 0.23 points [95% CI, 0.08, 0.37],\n                      <jats:italic>p<\/jats:italic>\n                      = 0.003); however, only BMR demonstrated significant effects on global cognitive function (BMR vs. Control: 0.22 [95% CI, 0.09, 0.35],\n                      <jats:italic>p<\/jats:italic>\n                      = 0.001; BM vs. Control: 0.17 [95% CI, 0.04, 0.30],\n                      <jats:italic>p<\/jats:italic>\n                      = 0.01). No significant effect of Baduanjin alone was observed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>A multi\u2010domain comprehensive intervention combining Baduanjin exercise, MIND diet and relaxation training, can significantly improve both executive function and global cognitive function after 9 months in older adults with cognitive impairment. These findings supported the use of these interventions to enhance cognitive function in older adults.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>Chinese clinical registry, registration number: ChiCTR2100045375.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/trc2.70221","type":"journal-article","created":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T07:13:42Z","timestamp":1770880422000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Effects of multidomain intervention on cognitive function in older adults with cognitive impairment: A multicenter, four\u2010arm, cluster randomized trial"],"prefix":"10.1002","volume":"12","author":[{"given":"Zhaoxue","family":"Yin","sequence":"first","affiliation":[{"name":"Chinese Center for Disease Control and Prevention  Beijing 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