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Recent approvals of amyloid\u2010targeting antibodies confirm target engagement but also expose the limitations of single\u2010target strategies in a disease shaped by interacting processes, including amyloid pathology, tau aggregation, neuroinflammation, vascular dysfunction, and metabolic disturbances. These limitations suggest that therapeutic approaches should target multiple pathways rather than isolated lesions. Over the past two decades, cancer therapy has shifted toward rational combinations, multi\u2010target interventions, drug repurposing, and adaptive trial designs. Several of these principles are directly relevant to AD. Recent studies, including work showing that combinations of approved anticancer agents can reverse AD\u2010related network dysfunction across multiple brain cell types, suggest that repurposing oncology drugs for neurodegeneration is biologically plausible. An added advantage is that repurposing builds on existing safety, pharmacokinetic, and clinical experience, which may reduce development time and cost. In this\n                      <jats:italic>Perspective<\/jats:italic>\n                      , we discuss how oncology\u2010informed repurposing strategies, combined with biomarker\u2010based enrichment, system\u2010level pharmacology, and adaptive platform trials, could support more integrated therapeutic development for AD. We also consider practical translational and regulatory issues, including expectations for demonstrating combination benefit, managing drug\u2013drug interactions, and navigating intellectual property pathways. Together, these cross\u2010disciplinary strategies offer a realistic path toward treatments that can produce durable, population\u2010level benefits.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/trc2.70231","type":"journal-article","created":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T03:02:35Z","timestamp":1773111755000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Oncology drug repurposing as a blueprint for Alzheimer's therapy"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5973-5990","authenticated-orcid":false,"given":"Viswanath","family":"Das","sequence":"first","affiliation":[{"name":"Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry Palack\u00fd University and University Hospital Olomouc  Olomouc Czech Republic"},{"name":"Czech Advanced Technologies and Research Institute (CATRIN), Institute of Molecular and Translational Medicine Palack\u00fd University Olomouc  Olomouc Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4834-908X","authenticated-orcid":false,"given":"Mari\u00e1n","family":"Hajd\u00fach","sequence":"additional","affiliation":[{"name":"Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry Palack\u00fd University and University Hospital Olomouc  Olomouc Czech Republic"},{"name":"Czech Advanced Technologies and Research Institute (CATRIN), Institute of Molecular and Translational Medicine Palack\u00fd University Olomouc  Olomouc Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,3,9]]},"reference":[{"key":"e_1_2_17_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468\u20102667(21)00249\u20108"},{"key":"e_1_2_17_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2025.13931"},{"key":"e_1_2_17_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40120\u2010025\u201000815\u2010w"},{"key":"e_1_2_17_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.70258"},{"key":"e_1_2_17_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2025.06.035"},{"key":"e_1_2_17_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195\u2010024\u201001441\u20108"},{"key":"e_1_2_17_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2212948"},{"key":"e_1_2_17_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2023.13239"},{"key":"e_1_2_17_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195\u2010024\u201001669\u20104"},{"key":"e_1_2_17_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2025.0065"},{"key":"e_1_2_17_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2025.1599048"},{"key":"e_1_2_17_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.14134"},{"key":"e_1_2_17_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474\u20104422(21)00375\u20106"},{"key":"e_1_2_17_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines7040097"},{"key":"e_1_2_17_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392\u2010024\u201001911\u20103"},{"key":"e_1_2_17_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195\u2010025\u201001775\u2010x"},{"key":"e_1_2_17_18_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000011883"},{"key":"e_1_2_17_19_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2023.1206572"},{"key":"e_1_2_17_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21093272"},{"key":"e_1_2_17_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010025\u201056690\u20104"},{"key":"e_1_2_17_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2025.104390"},{"key":"e_1_2_17_23_1","unstructured":"Guidance for industry\u2014Codevelopment of two or more new investigational drugs for use in combination2013.https:\/\/www.fda.gov\/files\/drugs\/published\/Codevelopment\u2010of\u2010Two\u2010or\u2010More\u2010New\u2010Investigational\u2010Drugs\u2010for\u2010Use\u2010in\u2010Combination.pdf"},{"key":"e_1_2_17_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xphs.2023.04.004"},{"key":"e_1_2_17_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12450"},{"key":"e_1_2_17_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trci.2018.04.008"},{"key":"e_1_2_17_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/trc2.70098"},{"key":"e_1_2_17_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.btre.2025.e00909"},{"key":"e_1_2_17_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/med.22033"},{"key":"e_1_2_17_30_1","unstructured":"European Medicines Agency. 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