{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T03:14:39Z","timestamp":1788146079737,"version":"build-2803163510"},"reference-count":50,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T00:00:00Z","timestamp":1778630400000},"content-version":"vor","delay-in-days":42,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["A&amp;amp;D Transl Res &amp;amp; Clin Interv"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>The burden experienced by caregivers of Alzheimer\u00b4s disease (AD) patients is a complex and stressful situation influenced by distinct variables, such as the patient\u00b4s need for monitoring, social isolation, mental or physical health problems, or financial challenges. In additon, behavioral and psychological symptoms of dementia are strongly associated with caregiver experiences of burden.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>This was a 12\u2010month, retrospective, single\u2010center, real\u2010world study to evaluate the effectiveness of the combined treatment with Souvenaid and acetylcholinesterase inhibitors (AChEI) compared to treatment with either AChEI alone or Souvenaid alone on caregiver burden, anxiety and depression in patients, and AD patients attending a memory clinic. Assessments were conducted using the Zarit Burden Interview (ZBI), the Beck Depression Inventory (BDI), the State Trait Anxiety Inventory\u2010State (STAI\u2010S), and the Neuropsychiatric Inventory\u2010Caregiver distress scale (NPI\u2010D). A mixed model for repeated measures was conducted to evaluate differences from baseline to month 12 between caregivers in the three treatment groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      At 12 months, caregiver burden, depression, anxiety levels, and the emotional distress in the context of behavioral and psychological symptoms of dementia (BPSD) improved in caregivers in the Souvenaid plus AChEI group (\n                      <jats:italic>n<\/jats:italic>\n                      = 70) compared to those in the AChEI group (\n                      <jats:italic>n<\/jats:italic>\n                      = 84) and those in the Souvenaid group (\n                      <jats:italic>n<\/jats:italic>\n                      = 66).\n                    <\/jats:p>\n                    <jats:p>The mean change for the ZBI score was found to be significantly higher in the Souvenaid plus AChEI group than in the AChEI group (p &lt; 0.001) and the Souvenaid group (p &lt; 0.001). In addition, there was a significant difference in the mean change for the BDI, STAI\u2010S, and NPI\u2010D scores between groups, favoring the Souvenaid plus AChEI group over the AChEI and Souvenaid groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>In addition to assessing patients' cognitive, behavioral, and daily functioning, it is recommended regular monitoring of caregiver burden while providing support for patients with dementia. The combined treatment with Souvenaid and AChEI may have a significant impact on caregivers\u2019 experience of burden.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/trc2.70262","type":"journal-article","created":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T03:22:07Z","timestamp":1778728927000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effectiveness of Souvenaid\u00ae combined with acetylcholinesterase inhibitors on caregiver burden in Alzheimer\u00b4s disease"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2951-6644","authenticated-orcid":false,"given":"Jos\u00e9 Mar\u00eda","family":"GARC\u00cdA\u2010ALBERCA","sequence":"first","affiliation":[{"name":"Alzheimer Research Center and Memory Clinic Instituto Andaluz de Neurociencia (IANEC)  M\u00e1laga Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"MENDOZA","sequence":"additional","affiliation":[{"name":"Alzheimer Research Center and Memory Clinic Instituto Andaluz de Neurociencia (IANEC)  M\u00e1laga Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paz","family":"DE LA GU\u00cdA","sequence":"additional","affiliation":[{"name":"Alzheimer Research Center and Memory Clinic Instituto Andaluz de Neurociencia (IANEC)  M\u00e1laga Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"L\u00d3PEZ DE LA RICA","sequence":"additional","affiliation":[{"name":"Alzheimer Research Center and Memory Clinic Instituto Andaluz de Neurociencia (IANEC)  M\u00e1laga Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,13]]},"reference":[{"key":"e_1_2_10_2_1","first-page":"44","volume-title":"Global action plan on the public health response to dementia 2017\u20102025","author":"World Health Organization","year":"2017"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.2190\/PM.41.1.f"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/ppc.12476"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0144686X19000527"},{"issue":"1","key":"e_1_2_10_6_1","first-page":"52","article-title":"Informal caregiving for dementia patients: the contribution of patient characteristics and behaviours to caregiver burden","volume":"49","author":"llen AP","year":"2019","journal-title":"Age Ageing"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10880-024-10052-2"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1590\/1980-57642021dn15-010014"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/08919887231195228"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/psyg.12197"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2023.1104250"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/13607863.2015.1102196"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1041610216000922"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjo.2021.760"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12913-020-05964-2"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0247143"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph23010104"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11920-017-0818-2"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.maturitas.2010.02.009"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2012-112039"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.R076331"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12172"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-221003"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.139.9.1136"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/geront\/20.6.649"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/0272-7358(88)90050-5"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1037\/013734"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.1998.tb02542.x"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.44.12.2308"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12877-024-05221-9"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/gps.5244"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajp.2017.01.002"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1177\/0891988719868313"},{"issue":"1","key":"e_1_2_10_34_1","first-page":"S167","article-title":"Souvenaid in cognitive deterioration. Our experience after 5 years of treatment and follow\u2010up","volume":"5","author":"Aguilar M","year":"2018","journal-title":"J Prev Alzheimers Dis"},{"key":"e_1_2_10_35_1","first-page":"68","article-title":"Effectiveness of a specific nutritional supplement on cognitive, behavioral and functional symptoms in mild cognitive impairment and Alzheimer's dementia: caregivers judgments. Results of an observational survey","volume":"66","author":"Bianchetti A","year":"2018","journal-title":"J Gerontol Geriatr"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/gps.70195"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1041610209990354"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.12779\/dnd.2025.24.1.24"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1097\/00019442-200509000-00008"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2648.2011.05787.x"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/gps.4965"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12603-014-0500-x"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apnu.2011.02.003"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1177\/0891988708320972"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1080\/13607863.2011.615738"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2009.10.003"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2012-121189"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-190546"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.2174\/1381612043386509"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0086558"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-017-0286-2"}],"container-title":["Alzheimer's &amp; Dementia: Translational Research &amp; Clinical Interventions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/trc2.70262","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/trc2.70262","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/trc2.70262","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T02:50:14Z","timestamp":1788144614000},"score":1,"resource":{"primary":{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/10.1002\/trc2.70262"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":50,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["10.1002\/trc2.70262"],"URL":"https:\/\/doi.org\/10.1002\/trc2.70262","archive":["Portico"],"relation":{},"ISSN":["2352-8737","2352-8737"],"issn-type":[{"value":"2352-8737","type":"print"},{"value":"2352-8737","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"2026-03-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70262"}}