{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T06:01:08Z","timestamp":1790402468576,"version":"4.1.0"},"reference-count":50,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T00:00:00Z","timestamp":1784332800000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100021790","name":"Fondation pour la Recherche sur Alzheimer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100021790","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003750","name":"Association France Alzheimer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003750","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["A&amp;D Transl Res &amp; Clin Interv"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>\n                      Dementia with Lewy bodies (DLB) and Alzheimer's disease (AD) are neurocognitive disorders characterized by distinct but often overlapping pathological processes. These include\n                      <jats:italic>\u03b1<\/jats:italic>\n                      \u2010synuclein, amyloid\u2010beta 42 (A\u03b242), and tau protein aggregation. While cerebrospinal fluid (CSF) biomarkers provide in vivo insight into these pathologies, their relationship with large\u2010scale brain network dysfunction remains poorly understood. This study aimed to investigate the associations between CSF biomarker concentrations and resting\u2010state functional connectivity in patients with DLB, AD, and mixed AD\/DLB.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      Sixty\u2010nine DLB patients, 17 AD patients, and 24 patients with mixed AD\/DLB underwent clinical and neuropsychological evaluations, lumbar puncture for CSF biomarker analysis (total\n                      <jats:italic>\u03b1<\/jats:italic>\n                      \u2010synuclein, A\u03b242, pTau\n                      <jats:sub>181<\/jats:sub>\n                      , and tTau), and resting\u2010state functional MRI. Patients were stratified by disease stage for subgroup analyses. Besides CSF total\n                      <jats:italic>\u03b1<\/jats:italic>\n                      \u2010synuclein levels,\u00a0\n                      <jats:italic>\u03b1<\/jats:italic>\n                      \u2010synuclein seeding activity was assessed using real\u2010time quaking\u2010induced conversion (RT\u2010QuIC) assays. ROI\u2010to\u2010ROI analyses were conducted using the CONN toolbox to explore associations between CSF biomarker levels and functional connectivity within and between major brain networks.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      In DLB patients, lower CSF\n                      <jats:italic>\u03b1<\/jats:italic>\n                      \u2010synuclein levels correlated with increased connectivity within the default mode network (DMN) (\n                      <jats:italic>p<\/jats:italic>\n                      <jats:sub>FDR<\/jats:sub>\n                      &lt; 0.05). In dementia\u2010stage DLB (d\u2010DLB), lower A\u03b242 levels correlated with reduced connectivity within the salience network (SN) (\n                      <jats:italic>p<\/jats:italic>\n                      <jats:sub>FDR<\/jats:sub>\n                      &lt; 0.05). In AD, higher tTau levels correlated with decreased connectivity between the DMN and the SN (\n                      <jats:italic>p<\/jats:italic>\n                      <jats:sub>FDR<\/jats:sub>\n                      &lt; 0.05). No significant associations were observed for CSF pTau\n                      <jats:sub>181<\/jats:sub>\n                      or any RT\u2010QuIC metric in any group, and the mixed AD\/DLB group showed no biomarker\u2013connectivity correlations at all.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>\n                      We identified distinct patterns of DMN and SN connectivity changes associated with CSF\n                      <jats:italic>\u03b1<\/jats:italic>\n                      \u2010synuclein and A\u03b242 levels, respectively. These findings reflect key functional disruptions that may contribute to core clinical symptoms. They underscore the value of combining CSF biomarkers with functional MRI to elucidate DLB pathophysiology.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/trc2.70266","type":"journal-article","created":{"date-parts":[[2026,7,19]],"date-time":"2026-07-19T04:41:29Z","timestamp":1784436089000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cerebrospinal fluid\n                    <i>\u03b1<\/i>\n                    \u2010synuclein and A\u03b242 link with default mode and salience networks connectivity in dementia with Lewy bodies"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-6107-4783","authenticated-orcid":false,"given":"Vincent","family":"Gabriel","sequence":"first","affiliation":[{"name":"ICube Laboratory UMR\u20107357 and FMTS (F\u00e9d\u00e9ration de M\u00e9decine Translationnelle de Strasbourg), IMIS team and IRIS platform University of Strasbourg and CNRS  Strasbourg France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Chabran","sequence":"additional","affiliation":[{"name":"ICube Laboratory UMR\u20107357 and FMTS (F\u00e9d\u00e9ration de M\u00e9decine Translationnelle de Strasbourg), IMIS team and IRIS platform University of Strasbourg and CNRS  Strasbourg France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marion","family":"Sourty","sequence":"additional","affiliation":[{"name":"ICube Laboratory UMR\u20107357 and FMTS (F\u00e9d\u00e9ration de M\u00e9decine Translationnelle de Strasbourg), IMIS team and IRIS platform University of Strasbourg and CNRS  Strasbourg France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Cretin","sequence":"additional","affiliation":[{"name":"ICube Laboratory UMR\u20107357 and FMTS (F\u00e9d\u00e9ration de M\u00e9decine Translationnelle de Strasbourg), IMIS team and IRIS platform University of Strasbourg and CNRS  Strasbourg France"},{"name":"CM2R (Centre de M\u00e9moire Ressources et Recherche), Geriatrics Department and Neurology Service Geriatric Day Hospital and Neuropsychological UnitUniversity Hospital of Strasbourg  Strasbourg France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Philippi","sequence":"additional","affiliation":[{"name":"ICube Laboratory UMR\u20107357 and FMTS (F\u00e9d\u00e9ration de M\u00e9decine Translationnelle de Strasbourg), IMIS team and IRIS platform University of Strasbourg and CNRS  Strasbourg France"},{"name":"CM2R (Centre de M\u00e9moire Ressources et Recherche), Geriatrics Department and Neurology Service Geriatric Day Hospital and Neuropsychological UnitUniversity Hospital of Strasbourg  Strasbourg France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Candice","family":"Muller","sequence":"additional","affiliation":[{"name":"CM2R (Centre de M\u00e9moire Ressources et Recherche), Geriatrics Department and Neurology Service Geriatric Day Hospital and Neuropsychological UnitUniversity Hospital of Strasbourg  Strasbourg France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Anthony","sequence":"additional","affiliation":[{"name":"CM2R, Geriatrics Division Geriatric Day Hospital, Civil Hospitals of Colmar  Colmar France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Demuynck","sequence":"additional","affiliation":[{"name":"CM2R (Centre de M\u00e9moire Ressources et Recherche), Geriatrics Department and Neurology Service Geriatric Day Hospital and Neuropsychological UnitUniversity Hospital of Strasbourg  Strasbourg France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulo Loureiro","family":"de Sousa","sequence":"additional","affiliation":[{"name":"ICube Laboratory UMR\u20107357 and FMTS (F\u00e9d\u00e9ration de M\u00e9decine Translationnelle de Strasbourg), IMIS team and IRIS platform University of Strasbourg and CNRS  Strasbourg France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Botzung","sequence":"additional","affiliation":[{"name":"ICube Laboratory UMR\u20107357 and FMTS (F\u00e9d\u00e9ration de M\u00e9decine Translationnelle de Strasbourg), IMIS team and IRIS platform University of Strasbourg and CNRS  Strasbourg France"},{"name":"CM2R (Centre de M\u00e9moire Ressources et Recherche), Geriatrics Department and Neurology Service Geriatric Day Hospital and Neuropsychological UnitUniversity Hospital of Strasbourg  Strasbourg France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00e9a","family":"Sanna","sequence":"additional","affiliation":[{"name":"CM2R (Centre de M\u00e9moire Ressources et Recherche), Geriatrics Department and Neurology Service Geriatric Day Hospital and Neuropsychological UnitUniversity Hospital of Strasbourg  Strasbourg France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Bousiges","sequence":"additional","affiliation":[{"name":"ICube Laboratory UMR\u20107357 and FMTS (F\u00e9d\u00e9ration de M\u00e9decine Translationnelle de Strasbourg), IMIS team and IRIS platform University of Strasbourg and CNRS  Strasbourg France"},{"name":"Laboratory of Biochemistry and Molecular Biology University Hospital of Strasbourg  Strasbourg France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fr\u00e9d\u00e9ric","family":"Blanc","sequence":"additional","affiliation":[{"name":"ICube Laboratory UMR\u20107357 and FMTS (F\u00e9d\u00e9ration de M\u00e9decine Translationnelle de Strasbourg), IMIS team and IRIS platform University of Strasbourg and CNRS  Strasbourg France"},{"name":"CM2R (Centre de M\u00e9moire Ressources et Recherche), Geriatrics Department and Neurology Service Geriatric Day Hospital and Neuropsychological UnitUniversity Hospital of Strasbourg  Strasbourg France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,18]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000004058"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(15)00462\u20106"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.11.6469"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474\u20104422(16)30291\u20105"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2020.09.030"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12814"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2024.3770"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2018.01.010"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD\u2010150731"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp\u20102017\u2010316385"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.111"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195\u2010020\u201000684\u20105"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0081654"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/acn3.338"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010neuro\u2010071013\u2010014030"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1440.011"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/13872877251386844"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195\u2010019\u20100575\u2010z"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5587\u201006.2007"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscychresns.2014.06.004"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awz026"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010017\u201001150\u2010x"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.62.2.181"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.22839"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100404.1997.tb00299.x"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2007.116830"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.03.008"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474\u20104422(14)70090\u20100"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.naj.0000314810.46029.74"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000009323"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/dad2.70066"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1089\/brain.2012.0073"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1212\/wnl.0b013e31827689d6"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11910\u2010024\u201001365\u20108"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00429\u2010010\u20100262\u20100"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.13034"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.28941"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2019.102052"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awab218"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2011.08.003"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11357\u2010025\u201001513\u2010z"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195\u2010016\u20100198\u20106"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195\u2010019\u20100537\u20105"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2024.107255"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2018.02.018"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593\u2010018\u20100070\u2010z"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010019\u201014159\u20101"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2019.10.010"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474\u20104422(23)00405\u20102"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2018.00138"}],"container-title":["Alzheimer's &amp; Dementia: Translational Research &amp; Clinical Interventions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/trc2.70266","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/trc2.70266","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/trc2.70266","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T05:52:43Z","timestamp":1790401963000},"score":1,"resource":{"primary":{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/10.1002\/trc2.70266"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":50,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1002\/trc2.70266"],"URL":"https:\/\/doi.org\/10.1002\/trc2.70266","archive":["Portico"],"relation":{},"ISSN":["2352-8737","2352-8737"],"issn-type":[{"value":"2352-8737","type":"print"},{"value":"2352-8737","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"2025-08-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70266"}}