{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T03:14:36Z","timestamp":1788146076018,"version":"build-2803163510"},"reference-count":37,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T00:00:00Z","timestamp":1782086400000},"content-version":"vor","delay-in-days":82,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100006034","name":"University of Southern California","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006034","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01AG083189"],"award-info":[{"award-number":["R01AG083189"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004896","name":"Eisai Incorporated","doi-asserted-by":"publisher","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}],"id":[{"id":"10.13039\/501100004896","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["A&amp;amp;D Transl Res &amp;amp; Clin Interv"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>Amyloid\u2010targeting treatments (ATT) for Alzheimer's disease require regular infusions and caregiver accompaniment for approximately 80% of patients. Travel time to infusion sites and caregiver availability can therefore impede access to care, especially in rural and lower income populations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>We conducted a survey in a nationally representative Internet panel with more than 2300 adults aged \u226565 years to estimate willingness to travel for bi\u2010weekly infusion treatment, and access to an accompanying caregiver. Addresses of respondents and infusion sites were geocoded and driving times to the nearest infusion centers were calculated using Google Maps road network data. To estimate potential access gains under subcutaneous (SC) delivery, we estimated access by relaxing the travel and accompaniment requirements in a scenario analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Median willingness\u2010to\u2010travel time was 97.5\u00a0minutes (interquartile range [IQR]: 67.5\u2013187.5\u00a0minutes) one way for bi\u2010weekly infusions over a 5\u2010year period. Approximately 90% of respondents were willing to travel the required time to reach an infusion site. However, 18% indicated that it would be unlikely that they could identify someone to accompany them. When caregiver accompaniment was incorporated as a constraint, 75% met both the travel and caregiver criteria. In regression analysis, respondents with annual incomes above $60,000 and those residing in metropolitan areas were 9 and 19 percentage points more likely, respectively, to meet travel and caregiver criteria. In a scenario analysis, SC delivery increased overall access by up to 33%, in relative terms, with larger proportional gains for low income and rural respondents.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>A meaningful number of individuals in a nationally representative sample live farther from their nearest site than they would be willing to travel, and obstacles to access worsen if individuals need a caregiver to accompany them, as is common among early\u2010stage AD patients. Treatments that do not require infusion delivery could improve equitable access to care.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/trc2.70282","type":"journal-article","created":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T08:56:00Z","timestamp":1782118560000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Travel barriers to amyloid\u2010targeting infusion access among older adults"],"prefix":"10.1002","volume":"12","author":[{"given":"Jeremy","family":"Burke","sequence":"first","affiliation":[{"name":"The USC Brain Health Observatory University of Southern California  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert","family":"Weerman","sequence":"additional","affiliation":[{"name":"The USC Brain Health Observatory University of Southern California  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Hanson","sequence":"additional","affiliation":[{"name":"The USC Brain Health Observatory University of Southern California  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quanwu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Eisai  Nutley New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir Abbas Tahami","family":"Monfared","sequence":"additional","affiliation":[{"name":"Eisai  Nutley New Jersey USA"},{"name":"McGill University, Epidemiology, Biostatistics, and Occupational Health  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4666-9132","authenticated-orcid":false,"given":"Soeren","family":"Mattke","sequence":"additional","affiliation":[{"name":"The USC Brain Health Observatory University of Southern California  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,22]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2023.13239"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa2212948"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz70861_108905"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.14283\/jpad.2023.30"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tjpad.2025.100150"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12470"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.14283\/jpad.2024.81"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/healthcare13192533"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.170554"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2015.61.1558"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tjpad.2024.100036"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jebo.2022.03.028"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen\u20102024\u2010088183"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.2307\/1242453"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.2307\/3146514"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/978\u201088\u2010470\u20105480\u20106_2"},{"issue":"4","key":"e_1_2_9_18_1","first-page":"213","article-title":"Stated preference methods in health care evaluation: an emerging methodological paradigm in health economics","volume":"2","author":"Bridges JF","year":"2003","journal-title":"Appl Health Econ Health Policy"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.2165\/00019053\u2010200826080\u201000004"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1370\/afm.816"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.retrec.2023.101381"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2025.60280"},{"key":"e_1_2_9_23_1","unstructured":"American Association for Public Opinion Research (AAPOR).Best Practices for Survey Research.2025. 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