{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T20:46:59Z","timestamp":1788900419276,"version":"build-2803163510"},"reference-count":40,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T00:00:00Z","timestamp":1782172800000},"content-version":"vor","delay-in-days":83,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["A&amp;amp;D Transl Res &amp;amp; Clin Interv"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>Person\u2010centered outcomes that capture clinically meaningful change are essential to non\u2010pharmacological intervention research for Alzheimer's disease and related dementias. Primary progressive aphasia (PPA) is a neurodegenerative syndrome characterized by progressive language impairment. The Communication Bridge\u20102 (CB2) randomized controlled trial previously demonstrated the efficacy of a personalized, participation\u2010focused speech\u2010language intervention on Goal Attainment Scaling (GAS), a person\u2010centered communication participation outcome. This secondary responder analysis characterized meaningful participant\u2010 and goal\u2010level response following intervention and at 12 months after enrollment to inform clinical translation and future appropriate use criteria.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      Fifty participants with mild to moderate PPA in the CB2 experimental arm, each with three individualized communication participation goals (\n                      <jats:italic>N<\/jats:italic>\n                      = 150 goals), were included. Prespecified responder thresholds were defined as GAS \u22651 following each intervention block and GAS \u22650 at 12 months, reflecting improvement or maintenance relative to baseline in a progressive condition. Descriptive analyses examined responder patterns across time points, participants, baseline severity, PPA subtypes, and goal characteristics.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>All participants met responder criteria at one or more evaluation time points. At 12 months, 79% of goals met responder criteria, and 60% of participants met responder criteria across all three goals. More than half of the goals (51.3%) met responder criteria at all three evaluation time points. Meaningful response was observed across PPA subtypes, baseline severity levels, and diverse goal characteristics. Exploratory patterns suggested higher 12\u2010month responder rates for goals targeting speech, familiar communication partners, and familiar communication contexts.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>This secondary responder analysis demonstrates that a person\u2010centered, participation\u2010focused speech\u2010language intervention was associated with meaningful goal\u2010level improvement or maintenance across a heterogeneous PPA population, with many responses sustained over 12 months. These findings support the value of GAS as a pragmatic, person\u2010centered outcome for capturing meaningful response in progressive neurodegenerative disease and provide translational evidence to inform future appropriate use criteria and individualized dementia care.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/trc2.70283","type":"journal-article","created":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T03:42:13Z","timestamp":1782272533000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Person\u2010centered intervention response in primary progressive aphasia: A secondary analysis of the Communication Bridge\u20102 randomized clinical trial"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6472-1363","authenticated-orcid":false,"given":"Emily","family":"Rogalski","sequence":"first","affiliation":[{"name":"Healthy Aging &amp; Alzheimer's Research Care (HAARC) Center, Biological Sciences Division University of Chicago  Chicago Illinois USA"},{"name":"Department of Neurology, Biological Sciences Division University of Chicago  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ollie","family":"Fegter","sequence":"additional","affiliation":[{"name":"Healthy Aging &amp; 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