{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T06:00:13Z","timestamp":1790402413969,"version":"4.1.0"},"reference-count":34,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T00:00:00Z","timestamp":1784160000000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100018528","name":"Korean Neurological Association","doi-asserted-by":"publisher","award":["KNA\u201024\u2010MI\u201017"],"award-info":[{"award-number":["KNA\u201024\u2010MI\u201017"]}],"id":[{"id":"10.13039\/100018528","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["A&amp;D Transl Res &amp; Clin Interv"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>Evidence from routine clinical practice regarding stage\u2010dependent responses to lecanemab remains limited. We examined early amyloid positron emission tomography (PET) and clinical trajectories according to disease stage in a real\u2010world cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      Among 89 patients who received lecanemab, 50 individuals with baseline amyloid positivity and follow\u2010up amyloid PET were included in the primary amyloid PET efficacy analysis. Amyloid burden was quantified using the Centiloid scale. Longitudinal Centiloid trajectories were analyzed using linear mixed\u2010effects models including disease stage, time from baseline amyloid PET, and the disease stage \u00d7 time interaction, with adjustment for cumulative dose exposure, age, sex, and apolipoprotein E (\n                      <jats:italic>APOE<\/jats:italic>\n                      ) \u03b54 carrier status. Cognitive and functional outcomes were assessed using mixed\u2010effects models.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Amyloid burden decreased substantially during follow\u2010up. After adjustment for cumulative dose exposure, age, sex, and\n                      <jats:italic>APOE<\/jats:italic>\n                      \u03b54 carrier status, the disease stage \u00d7 time interaction was significant (\u03b2\u00a0=\u00a0+1.62 Centiloid\/month; 95% confidence interval, 0.80 to 2.43;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001), indicating a faster rate of Centiloid reduction in patients with mild cognitive impairment (MCI) than in those with dementia (estimated \u22122.34\u00a0vs. \u22120.72 Centiloid\/month). Conversion to amyloid\u2010negative status (full treatment\u2010related amyloid clearance) occurred in 9 of 50 patients (18.0%) and was more frequent at the MCI stage (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.022). Patients treated at the MCI stage also showed more favorable short\u2010term cognitive and functional trajectories than those treated at the dementia stage.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>In real\u2010world clinical practice, lecanemab treatment was associated with substantial amyloid reduction, with faster amyloid clearance observed at the MCI stage. These findings support the potential value of earlier intervention with anti\u2010amyloid therapy, although longer follow\u2010up and controlled comparisons are needed to determine whether early biomarker changes translate into sustained clinical benefit.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/trc2.70300","type":"journal-article","created":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T04:14:52Z","timestamp":1784261692000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Six\u2010month real\u2010world amyloid PET outcomes after lecanemab: Greater amyloid reduction at the MCI stage than in dementia"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5395-1924","authenticated-orcid":false,"given":"Geon Ha","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Neurology Ewha Womans University Mokdong Hospital Ewha Womans University College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai\u2010Jeon","family":"Yoon","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Ewha Womans University Mokdong Hospital Ewha Womans University College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun Hee","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Radiology Ewha Womans University Mokdong Hospital Ewha Womans University College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji\u2010Young","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Ewha Womans University Mokdong Hospital Ewha Womans University College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiyoung","family":"Yeom","sequence":"additional","affiliation":[{"name":"Department of Neurology Ewha Womans University Mokdong Hospital Ewha Womans University College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seo Young","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Ewha Womans University Seoul Hospital Ewha Womans University College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boeun","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Radiology Ewha Womans University Seoul Hospital Ewha Womans University College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7945-6956","authenticated-orcid":false,"given":"Jee Hyang","family":"Jeong","sequence":"additional","affiliation":[{"name":"Department of Neurology Ewha Womans University Seoul Hospital Ewha Womans University College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,16]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)32205-4"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40263-023-01021-8"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-025-01123-5"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-022-01124-2"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2212948"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2023.13239"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tjpad.2025.100202"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-023-01484-7"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/trc2.70165"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.70997"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2014.07.003"},{"key":"e_1_2_10_13_1","first-page":"2610","article-title":"Internal 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