{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T06:02:06Z","timestamp":1790402526551,"version":"4.1.0"},"reference-count":44,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T00:00:00Z","timestamp":1789862400000},"content-version":"vor","delay-in-days":81,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["A&amp;D Transl Res &amp; Clin Interv"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>In people with type 2 diabetes (T2D) without dementia, glucagon\u2010like peptide\u20101 receptor agonists (GLP\u20101 RAs) improved cardiovascular, kidney, and mortality outcomes, with multiple real\u2010world studies suggesting reduced risk of dementia onset. However, the EVOKE\/EVOKE+ randomized\u2010controlled trials (RCTs) found that oral semaglutide did not slow cognitive decline in individuals with early Alzheimer's disease (AD), most (86%) without T2D. It is unclear whether GLP\u20101 RA therapy influences progression to dementia in people with both T2D and mild cognitive impairment (MCI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>In a target\u2010trial emulation hypothesis\u2010generating study using TriNetX global collaborative network data, we compared incident dementia (including AD) in adults with MCI and T2D without dementia, who were new users of GLP\u20101 RAs versus dipeptidyl peptidase\u20104 inhibitors (DPP4i).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>We included 1320 propensity\u2010score\u2010matched (1:1) individuals who initiated GLP\u20101 RAs or DPP4i in the period 2010 to 2021 (702 women; mean age 67.2 years). Over up to 5 years of follow\u2010up, incident dementia occurred in 101 and 132 participants initiating GLP\u20101 RAs and DPP4i, respectively (Cox proportional hazard ratio 0.74 [95% confidence interval [CI]: 0.57 to 0.95]). At a mean follow\u2010up of 3.9 years, the respective Kaplan\u2010Meier\u2010derived cumulative incidences were 15.5% and 20.4% (absolute difference \u22124.9% [95% CI \u22129.4 to \u22120.4], number needed to treat of 21 [11 to 234] individuals to prevent one event). Various sensitivity analyses supported the primary analysis: comparing GLP\u20101 RAs with basal insulin, using alternative outcome definitions, repeating the analyses across baseline subgroups, and using a negative control outcome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>In this hypothesis\u2010generating study, initiation of GLP\u20101 RAs versus DPP4i in people with T2D and MCI without dementia was associated with a lower risk of incident dementia.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/trc2.70315","type":"journal-article","created":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T04:33:38Z","timestamp":1789965218000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Dementia progression with GLP\u20101 receptor agonists in people with mild cognitive impairment and type 2 diabetes: target\u2010trial emulation study"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5071-3143","authenticated-orcid":false,"given":"Meir","family":"Schechter","sequence":"first","affiliation":[{"name":"Diabetes Unit Department of Endocrinology and Metabolism Hadassah Medical Center  Jerusalem Israel"},{"name":"Faculty of Medicine Hebrew University of Jerusalem  Jerusalem Israel"},{"name":"Dina Recanati School of Medicine Reichman University  Herzliya Israel"},{"name":"The Gertner Institute for Epidemiology and Health Policy Research Sheba Medical Center  Ramat Gan Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dvora R","family":"Sehtman\u2010Shachar","sequence":"additional","affiliation":[{"name":"Diabetes Unit Department of Endocrinology and Metabolism Hadassah Medical Center  Jerusalem Israel"},{"name":"Faculty of Medicine Hebrew University of Jerusalem  Jerusalem 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