{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T03:44:56Z","timestamp":1791776696413,"version":"4.3.4"},"reference-count":105,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T00:00:00Z","timestamp":1791676800000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100002803","name":"Fondazione Cariplo","doi-asserted-by":"publisher","award":["2021\u20101516"],"award-info":[{"award-number":["2021\u20101516"]}],"id":[{"id":"10.13039\/501100002803","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021790","name":"Fondation pour la Recherche sur Alzheimer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100021790","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["RO1NS139383"],"award-info":[{"award-number":["RO1NS139383"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000971","name":"ALS Association","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000971","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000833","name":"Rosetrees Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000833","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["A&amp;D Transl Res &amp; Clin Interv"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>Frontotemporal lobar degeneration (FTLD) comprises a group of neuropathological entities underlying a spectrum of clinical syndromes, including behavioral variant frontotemporal dementia, the primary progressive aphasias, progressive supranuclear palsy, and corticobasal syndrome. Their marked biological and clinical heterogeneity is among the reasons why no disease\u2010modifying therapy has been approved.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>We systematically mapped the 2026 therapeutic pipeline by searching ClinicalTrials.gov, the EU Clinical Trials Register, the Clinical Trials Information System, and the International Standard Randomised Controlled Trial Number (ISRCTN) registry for active interventional studies up to May 31, 2026, including Phase 1\u20133 pharmacological and neuromodulation trials.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Thirty\u2010eight active trials were identified (19 pharmacological and 19 neuromodulation), comprising 7 Phase 1 and 11 Phase 2 studies, and 1 Phase 3 study. Neuromodulation accounted for half of the pipeline, predominantly targeting language networks in primary progressive aphasia. Disease\u2010targeted approaches focused mainly on progranulin restoration in\n                      <jats:italic>granulin<\/jats:italic>\n                      (\n                      <jats:italic>GRN<\/jats:italic>\n                      )\u2010FTD (frontotemporal dementia) and tau\u2010related mechanisms. Biomarker outcomes were incorporated in 25 trials (65.8%), whereas repurposed agents represented 13.2% of interventions.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Although the FTLD pipeline remains largely early stage, advances in mechanistically targeted therapies highlight the importance of proactive case\u2010finding, genetically stratified trial designs, biomarker\u2010guided diagnosis, and mechanism\u2010based therapeutic development.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/trc2.70326","type":"journal-article","created":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T02:54:11Z","timestamp":1791773651000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Frontotemporal lobar degeneration therapeutic development pipeline: 2026"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8703-6940","authenticated-orcid":false,"given":"Alberto","family":"Benussi","sequence":"first","affiliation":[{"name":"Neurology Unit, Department of Medical Surgical and Health Sciences University of Trieste  Trieste Italy"},{"name":"Neurology Unit Hospital Care Department of Medicine Azienda Sanitaria Universitaria Giuliano Isontina  Trieste Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aurora","family":"Saccavini","sequence":"additional","affiliation":[{"name":"Neurology Unit, Department of Medical Surgical and Health Sciences University of Trieste  Trieste Italy"},{"name":"Neurology Unit Hospital Care Department of Medicine Azienda Sanitaria Universitaria Giuliano Isontina  Trieste Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Palacino","sequence":"additional","affiliation":[{"name":"Neurology Unit, Department of Medical Surgical and Health Sciences University of Trieste  Trieste Italy"},{"name":"Neurology Unit Hospital Care Department of Medicine Azienda Sanitaria Universitaria Giuliano Isontina  Trieste Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bradley F.","family":"Boeve","sequence":"additional","affiliation":[{"name":"Department of Neurology Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam L.","family":"Boxer","sequence":"additional","affiliation":[{"name":"Memory and Aging Center Department of Neurology Weill Institute for Neurosciences University of California San Francisco  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward D.","family":"Huey","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Human Behavior Warren Alpert Medical School Brown University  Providence Rhode Island USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle Le","family":"Ber","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9 Paris Brain Institute \u2013 Institut du Cerveau (ICM), INSERM CNRS, AP\u2010HP Reference Centre for Rare and Early\u2010Onset Dementias (IM2A) Piti\u00e9\u2010Salp\u00eatri\u00e8re Hospital  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffaella L.","family":"Migliaccio","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9 Paris Brain Institute \u2013 Institut du Cerveau (ICM) AP\u2010HP Piti\u00e9\u2010Salp\u00eatri\u00e8re Hospital  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiadi U.","family":"Onyike","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences Johns Hopkins University School of Medicine  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Piguet","sequence":"additional","affiliation":[{"name":"School of Psychology and Brain &amp; Mind Centre The University of Sydney  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yolande A. L.","family":"Pijnenburg","sequence":"additional","affiliation":[{"name":"Alzheimer Center Amsterdam, Department of Neurology, Amsterdam UMC, Amsterdam Neuroscience, Neurodegeneration Vrije Universiteit Amsterdam  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan D.","family":"Rohrer","sequence":"additional","affiliation":[{"name":"Dementia Research Centre UCL Queen Square Institute of Neurology University College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James B.","family":"Rowe","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurosciences and Cambridge University Hospitals NHS Trust University of Cambridge  Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eino","family":"Solje","sequence":"additional","affiliation":[{"name":"Institute of Clinical Medicine \u2013 Neurology University of Eastern Finland  Kuopio Finland"},{"name":"Neuro Center \u2010 Neurology Kuopio University Hospital  Kuopio Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Otto","sequence":"additional","affiliation":[{"name":"Department of Neurology Martin\u2010Luther\u2010University Halle\u2010Wittenberg  Halle (Saale) Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Borroni","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Sciences University of Brescia  Brescia Italy"},{"name":"Molecular Markers Laboratory IRCCS Centro Istituto San Giovanni di Dio Fatebenefratelli  Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey L.","family":"Cummings","sequence":"additional","affiliation":[{"name":"Chambers\u2010Grundy Center for Transformative Neuroscience Department of Brain Health Kirk Kerkorian School of Medicine University of Nevada Las Vegas (UNLV)  Las Vegas Nevada USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,11]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572\u2010023\u201000447\u20100"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.20330.1"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31821103e6"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awr179"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/WAD.0b013e31815bf454"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2022.5128"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/JAMANEUROL.2025.3307"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/S00415\u2010023\u201011791\u20102"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-009-0612-2"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/nan.12250"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415\u2010019\u201009363\u20104"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2015.00171"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2018.10.009"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415\u2010020\u201009738\u2010y"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2022.861585"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/S41467\u2010022\u201030387\u20104"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/ALZ.14566"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474\u20104422(21)00341\u20100"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1080\/14737175.2023.2228491"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2100708"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.14283\/jpad.2023.123"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD\u2010230535"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/trc2.70098"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/trc2.12465"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awae292"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/TRC2.70251"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2012.05.2115"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1080\/13543784.2024.2349286"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.13588"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41582\u2010020\u20100330\u2010x"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42003\u2010025\u201008272\u20109"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974\u2010024\u201003039\u20101"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/TRC2.12452"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/ACN3.52234"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/S13311\u2010022\u201001260\u20105"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.3390\/IJTM5040052"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.2147\/JEP.S262352"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells14191506"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12453"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.29322"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1126\/SCIENCE.ABN1366"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms27094117"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/trc2.12033"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2025.2111459"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2019.00304"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/ANA.24766"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1186\/S13063\u2010019\u20103613\u2010Z"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1093\/BRAINCOMMS\/FCAC050"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.NICL.2025.103798"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.3389\/FNAGI.2020.578339"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1002\/ANA.78167"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.3390\/DIAGNOSTICS11050788"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1080\/09540261.2025.2572365"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1002\/ALZ.14250"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591\u2010026\u201004341\u20106"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1002\/ALZ.70989"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1038\/S41591\u2010024\u201002937\u20104"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1038\/S41591\u2010026\u201004398\u20103"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2020.30194"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.13640"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11940\u2010014\u20100319\u20100"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1136\/BMJOPEN\u20102025\u2010099577"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474\u20104422(24)00456\u20103"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.ARR.2024.102441"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474\u20104422(10)70195\u20102"},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.1007\/S00401\u2010023\u201002652\u20103"},{"key":"e_1_2_10_68_1","doi-asserted-by":"publisher","DOI":"10.1093\/BRAIN\/AWAE168"},{"key":"e_1_2_10_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(25)00513\u20106"},{"key":"e_1_2_10_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.CELREP.2019.04.003"},{"key":"e_1_2_10_71_1","doi-asserted-by":"publisher","DOI":"10.1186\/S13024\u2010025\u201000873\u20106"},{"key":"e_1_2_10_72_1","doi-asserted-by":"publisher","DOI":"10.1038\/S41586\u2010022\u201004650\u2010Z"},{"key":"e_1_2_10_73_1","doi-asserted-by":"publisher","DOI":"10.1186\/S13024\u2010023\u201000608\u20105"},{"key":"e_1_2_10_74_1","first-page":"109","article-title":"Imaging and fluid biomarkers in frontotemporal dementia","volume":"19","author":"Meeter LH","year":"2017","journal-title":"Nat Rev Neurol"},{"key":"e_1_2_10_75_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD\u2010215447"},{"key":"e_1_2_10_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bionps.2023.100065"},{"key":"e_1_2_10_77_1","doi-asserted-by":"publisher","DOI":"10.1002\/ALZ.71722"},{"key":"e_1_2_10_78_1","doi-asserted-by":"publisher","DOI":"10.1002\/MDS.25824"},{"key":"e_1_2_10_79_1","doi-asserted-by":"publisher","DOI":"10.1002\/MDS.25815"},{"key":"e_1_2_10_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474\u20104422(24)00335\u20101"},{"key":"e_1_2_10_81_1","doi-asserted-by":"publisher","DOI":"10.1002\/ALZ.14531"},{"key":"e_1_2_10_82_1","doi-asserted-by":"publisher","DOI":"10.1093\/BRAIN\/AWAB097"},{"key":"e_1_2_10_83_1","doi-asserted-by":"publisher","DOI":"10.1093\/BRAIN\/AWV133"},{"key":"e_1_2_10_84_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms252111838"},{"key":"e_1_2_10_85_1","doi-asserted-by":"publisher","DOI":"10.1186\/S13024\u2010025\u201000821\u20104"},{"key":"e_1_2_10_86_1","doi-asserted-by":"publisher","DOI":"10.1002\/dad2.70275"},{"key":"e_1_2_10_87_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD\u2010170584"},{"key":"e_1_2_10_88_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awx327"},{"key":"e_1_2_10_89_1","doi-asserted-by":"publisher","DOI":"10.3109\/21678421.2015.1074700"},{"key":"e_1_2_10_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474\u20104422(14)70324\u20102"},{"key":"e_1_2_10_91_1","doi-asserted-by":"publisher","DOI":"10.1002\/ALZ.12004"},{"key":"e_1_2_10_92_1","doi-asserted-by":"publisher","DOI":"10.3389\/FNEUR.2021.631722"},{"key":"e_1_2_10_93_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474\u20104422(19)30394\u20101"},{"key":"e_1_2_10_94_1","doi-asserted-by":"publisher","DOI":"10.1002\/ACN3.51744"},{"key":"e_1_2_10_95_1","doi-asserted-by":"publisher","DOI":"10.1002\/ALZ.076029"},{"key":"e_1_2_10_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.INPSYC.2025.100078"},{"key":"e_1_2_10_97_1","doi-asserted-by":"publisher","DOI":"10.1002\/ALZ.71431"},{"key":"e_1_2_10_98_1","doi-asserted-by":"publisher","DOI":"10.1002\/ALZ.078635"},{"key":"e_1_2_10_99_1","doi-asserted-by":"publisher","DOI":"10.1007\/S00115\u2010011\u20103261\u20103"},{"key":"e_1_2_10_100_1","doi-asserted-by":"publisher","DOI":"10.1001\/JAMANEUROL.2019.4347"},{"key":"e_1_2_10_101_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591\u2010024\u201002973\u20100"},{"key":"e_1_2_10_102_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz70859_102193"},{"key":"e_1_2_10_103_1","doi-asserted-by":"publisher","DOI":"10.1186\/S13063\u2010019\u20103664\u20101\/FIGURES\/4"},{"key":"e_1_2_10_104_1","doi-asserted-by":"publisher","DOI":"10.1002\/ALZ.14185"},{"key":"e_1_2_10_105_1","doi-asserted-by":"publisher","DOI":"10.1093\/BRAIN\/AWQ075"},{"key":"e_1_2_10_106_1","doi-asserted-by":"publisher","DOI":"10.1038\/S41380\u2010024\u201002847\u20104"}],"container-title":["Alzheimer's &amp; Dementia: Translational Research &amp; Clinical Interventions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/trc2.70326","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/trc2.70326","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/trc2.70326","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T02:54:15Z","timestamp":1791773655000},"score":1,"resource":{"primary":{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/10.1002\/trc2.70326"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":105,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1002\/trc2.70326"],"URL":"https:\/\/doi.org\/10.1002\/trc2.70326","archive":["Portico"],"relation":{},"ISSN":["2352-8737","2352-8737"],"issn-type":[{"value":"2352-8737","type":"print"},{"value":"2352-8737","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"2026-07-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70326"}}