{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T21:48:27Z","timestamp":1783547307774,"version":"3.55.0"},"reference-count":22,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,6,8]],"date-time":"2021-06-08T00:00:00Z","timestamp":1623110400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["UEG Journal"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Patients who develop upper gastrointestinal bleeding (UGIB) while in hospital appear to have a poor prognosis. Our study aims at analysing the difference in outcome between in\u2010patients (IPs) and out\u2010patients presenting with variceal and non\u2010variceal UGIB.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a multicentre prospective study by collecting data about variceal and non\u2010variceal UGIB cases through 46 hospitals in France between November 2017 and October 2018. We then compared baseline demographic features, endoscopic findings and outcome between patients who developed variceal and non\u2010variceal UGIB on admission (OPs) and those at least 24\u00a0h after hospitalisation (IPs). Our primary end\u2010point was mortality and re\u2010bleeding rates at 6 weeks of bleeding onset.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 2498 UGIB cases were identified, of whom 634 (25.4%) occurred in IPs. IPs were older than OPs (72.5 vs. 67.2\u00a0years old, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001) and had a higher rate of comorbidities (38.9% vs. 26.6%, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.0001). Their bleeding was more severe with a Rockall score of &gt;5 present in 40.9% (vs. 30.3% in OPs, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.0001). The 6\u2010week mortality rate was significantly higher in IPs when compared to OPs (21.7% vs. 8%, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.0001). Prothrombin time &lt;50% and rebleeding were the only independent predictors of mortality (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.001 and 0.003, respectively). Six\u2010week rebleeding occurred more frequently among IPs (18.6% vs. 14.4%, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.015) and predictors included female sex, active bleeding upon endoscopy and a Blatchford score &gt;11 (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.017, 0.011 and 0.008, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>IPs who develop variceal and non\u2010variceal UGIB are more likely to be elderly with more comorbidities. They have a higher rate of mortality and rebleeding. Independent predictors of mortality were underlying coagulopathy and bleeding recurrence. An optimal bleeding management and efficient rebleeding prevention may improve outcome in these patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ueg2.12096","type":"journal-article","created":{"date-parts":[[2021,6,9]],"date-time":"2021-06-09T11:06:12Z","timestamp":1623236772000},"page":"707-717","source":"Crossref","is-referenced-by-count":18,"title":["Prognosis of variceal and non\u2010variceal upper gastrointestinal bleeding in already hospitalised patients: Results from a French prospective cohort"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6205-4157","authenticated-orcid":false,"given":"Weam","family":"EL Hajj","sequence":"first","affiliation":[{"name":"Groupe Hospitalier Intercommunal Le Raincy\u2010Montfermeil  Montfermeil France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Quentin","sequence":"additional","affiliation":[{"name":"Centre Hospitalier de Saint Brieuc  Saint Brieuc 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