{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T00:26:30Z","timestamp":1767831990041,"version":"3.49.0"},"reference-count":37,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,6,24]],"date-time":"2021-06-24T00:00:00Z","timestamp":1624492800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["UEG Journal"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>No prognostic score is currently available for long\u2010term survival in autoimmune hepatitis (AIH) patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim of this study was to develop and validate such a prognostic score for AIH patients at diagnosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The prognostic score was developed using uni\u2010\u00a0&amp; multivariate Cox regression in a 4\u2010center Dutch cohort and validated in an independent 6\u2010center Belgian cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the derivation cohort of 396 patients 19 liver transplantations (LTs) and 51 deaths occurred (median follow\u2010up 118\u00a0months; interquartile range 60\u2013202\u00a0months). In multivariate analysis age (hazard ratio [HR] 1.045; <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001), non\u2010caucasian ethnicity (HR 1.897; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.045), cirrhosis (HR 3.266; <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001) and alanine aminotransferase level (HR 0.725; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.003) were significant independent predictors for mortality or LT (C\u2010statistic 0.827; 95% CI 0.790\u20130.864). In the validation cohort of 408 patients death or LT occurred in 78 patients during a median follow\u2010up of 74\u00a0months (interquartile range: 25\u2013142\u00a0months). Predicted 5\u2010year event rate did not differ from observed event rate (high risk group 21.5% vs. 15.7% (95% CI: 6.3%\u201324.2%); moderate risk group 5.8% versus 4.3% (95% CI: 0.0%\u20139.1%); low risk group 1.9% versus 5.4% (95% CI: 0.0%\u201311.4%); C\u2010statistic 0.744 [95% CI 0.644\u20130.844]).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A Dutch\u2010Belgian prognostic score for long\u2010term transplant\u2010free survival in AIH patients at diagnosis was developed and validated.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ueg2.12112","type":"journal-article","created":{"date-parts":[[2021,6,24]],"date-time":"2021-06-24T09:43:16Z","timestamp":1624527796000},"page":"662-671","source":"Crossref","is-referenced-by-count":11,"title":["Development and validation of a prognostic score for long\u2010term transplant\u2010free survival in autoimmune hepatitis type 1"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2797-6164","authenticated-orcid":false,"given":"Maaike","family":"Biewenga","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology Leiden University Medical Center  Leiden the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2798-5415","authenticated-orcid":false,"given":"Xavier P.D.M.J.","family":"Verhelst","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology UZ Ghent  Ghent Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martine A.M.C.","family":"Baven\u2010Pronk","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Green Heart Hospital  Gouda the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hein","family":"Putter","sequence":"additional","affiliation":[{"name":"Department of Biomedical Data Sciences Leiden University Medical Center  Leiden the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aad P.","family":"van den Berg","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology University Medical Center Groningen  Groningen the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karin C.M.J.","family":"van Nieuwkerk","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Amsterdam University Medical Center location VUmc  Amsterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henk R.","family":"van Buuren","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Erasmus MC  Rotterdam the 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