{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T03:12:16Z","timestamp":1777777936575,"version":"3.51.4"},"reference-count":31,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2021,8,25]],"date-time":"2021-08-25T00:00:00Z","timestamp":1629849600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003554","name":"Lundbeckfonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003554","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Fonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["UEG Journal"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Irritable bowel syndrome (IBS) is a chronic disorder associated with an abnormal gastrointestinal microbiome. Microbiome\u2013host interactions are known to influence organ function including in the central nervous system; thus, we sought to identify whether IBS may be a risk factor for the development of glaucoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Two prospective cohort studies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects<\/jats:title><jats:p>The 1958 United Kingdom Birth Cohort (UKBC; 9091 individuals) and the Danish National Registry of Patients (DNRP; 62,541 individuals with IBS and 625,410 matched general population cohort members).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In the UKBC, participants were surveyed throughout life (including at ages 42 and 50). The DNRP contains records of hospital\u2010based contacts and prescription data from the national prescription database.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main Outcome Measure<\/jats:title><jats:p>The main outcome measure was incidence of glaucoma. In the UKBC, incident glaucoma at age 50 (<jats:italic>n<\/jats:italic>\u00a0=\u00a048) was determined through comparison of survey responses at ages 42 and 50\u00a0years. In the DNRP, glaucoma was assessed by hospital diagnosis (<jats:italic>n<\/jats:italic>\u00a0=\u00a01510), glaucoma surgery (<jats:italic>n<\/jats:italic>\u00a0=\u00a0582) and initiation of glaucoma medications (<jats:italic>n<\/jats:italic>\u00a0=\u00a01674).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the UKBC, the odds ratio (OR) of developing glaucoma between ages\u00a042\u00a0and 50 in persons with a chronic IBS diagnosis was increased [OR: 5.84,\u00a095% confidence interval (CI): 2.26\u201315.13]. People with an IBS diagnosis in the\u00a0DNRP had a hazard ratio (HR) of 1.35 for developing physician\u2010diagnosed glaucoma (95% CI: 1.16\u20131.56), an HR of 1.35 for undergoing glaucoma surgery (95% CI: 1.06\u20131.70) and an HR of 1.19 for initiating glaucoma medication (95% CI: 1.03\u20131.38).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In two large European cohort studies, IBS is a risk factor for glaucoma.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ueg2.12136","type":"journal-article","created":{"date-parts":[[2021,8,25]],"date-time":"2021-08-25T10:55:14Z","timestamp":1629888914000},"page":"1057-1065","source":"Crossref","is-referenced-by-count":10,"title":["Irritable bowel syndrome and risk of glaucoma: An analysis of two independent population\u2010based cohort studies"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9072-013X","authenticated-orcid":false,"given":"Zachary 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