{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T15:32:03Z","timestamp":1768404723875,"version":"3.49.0"},"reference-count":55,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2021,10,8]],"date-time":"2021-10-08T00:00:00Z","timestamp":1633651200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["UEG Journal"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>With increasing number of clinical trials relating to fecal microbiota transplantation (FMT), it is crucial to identify and recruit long\u2010term, healthy, and regular fecal donors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>We aimed to report the outcomes of screening and recruitment of fecal donors for FMT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Potential donors were recruited via advertisement through internal mass emails at a university. They were required to undergo a pre\u2010screening telephone interview, a detailed questionnaire, followed by blood and stool investigations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>From January 2017 to December 2020, 119 potential donors were assessed with 75 failed pre\u2010screening. Reasons for failure included: inability to come back for regular and long\u2010term donation (<jats:italic>n<\/jats:italic>\u00a0=\u00a019), high body mass index (<jats:italic>n<\/jats:italic>\u00a0=\u00a017), underlying chronic illness or on long\u2010term medications (<jats:italic>n<\/jats:italic>\u00a0=\u00a011), being healthcare professionals (<jats:italic>n<\/jats:italic>\u00a0=\u00a010), use of antibiotics within 3\u00a0months (<jats:italic>n<\/jats:italic>\u00a0=\u00a05) and others (<jats:italic>n<\/jats:italic>\u00a0=\u00a013). Forty\u2010four donors completed questionnaires and 11 did not fulfill the clinical criteria. Of the remaining 33 potential donors who had stool and blood tests, 21 failed stool investigations (19 extended\u2010spectrum beta\u2010lactamase [ESBL] organisms, one <jats:italic>Clostridioides difficile<\/jats:italic>, one <jats:italic>C. difficile<\/jats:italic> plus Methicillin Resistant <jats:italic>Staphylococcus aureus<\/jats:italic>), one failed blood tests (high serum alkaline phosphatase level), one required long\u2010term medication and nine withdrew consent and\/or lost to follow\u2010up. In total, only one out of 119 (0.8%) potential donors was successfully recruited as a regular donor.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>There was a high failure rate in donor screening for FMT. Main reasons for screening failure included high prevalence of positive ESBL organisms in stool and failed commitment to regular stool donation.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ueg2.12160","type":"journal-article","created":{"date-parts":[[2021,10,10]],"date-time":"2021-10-10T08:38:56Z","timestamp":1633855136000},"page":"1027-1038","source":"Crossref","is-referenced-by-count":15,"title":["High prevalence of extended\u2010spectrum beta\u2010lactamase organisms and the COVID\u201019 pandemic impact on donor recruitment for fecal microbiota transplantation in Hong\u00a0Kong"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2865-5992","authenticated-orcid":false,"given":"Yuk Kam","family":"Yau","sequence":"first","affiliation":[{"name":"Center for Gut Microbiota Research Faculty of Medicine The Chinese University of Hong Kong  Hong Kong China"},{"name":"Department of Medicine &amp; Therapeutics Faculty of Medicine The Chinese University of Hong Kong  Hong Kong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5221-7349","authenticated-orcid":false,"given":"Wing Yan Joyce","family":"Mak","sequence":"additional","affiliation":[{"name":"Center for Gut Microbiota Research Faculty of Medicine The Chinese University of Hong Kong  Hong Kong China"},{"name":"Department of Medicine &amp; 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