{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T03:24:57Z","timestamp":1791516297515,"version":"4.3.4"},"reference-count":33,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,2,10]],"date-time":"2022-02-10T00:00:00Z","timestamp":1644451200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["UEG Journal"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Previously published short\u2010term results (week 16) of this trial showed a significant improvement in clinical, radiologic and biochemical outcomes in Crohn's disease patients with therapy\u2010refractory perianal fistulas after treatment with hyperbaric oxygen therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess the long\u2010term (week 60) efficacy, safety and feasibility of hyperbaric oxygen therapy in perianal fistula in Crohn's disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Crohn's disease patients with high perianal fistula(s) failing conventional treatment &gt;6\u00a0months were included. Exclusion criteria were presence of a stoma, rectovaginal fistula(s) and recent changes in treatment regimens. Patients received 40 hyperbaric oxygen sessions and outcomes were assessed at week 16 and week 60.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty patients were included (median age 34\u00a0years). At week 16, median scores of the perianal disease activity index and modified Van Assche index (co\u2010primary outcomes) decreased from 7.5 (95% CI 6\u20139) to 4 (95% CI 3\u20136, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001) and 9.2 (95% CI 7.3\u201311.2) to 7.3 (95% CI 6.9\u20139.7, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.004), respectively. At week 60, the respective scores remained significantly lower than baseline: 4 (95% CI 3\u20137, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001) and 7.7 (95% CI 5.2\u201310.2, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.003). Perianal disease activity index score of 4 or less (representing inactive perianal disease) was observed in 13 patients at week 16 and 12 patients at week 60. Using fistula drainage assessment, 12 and 13 patients showed a clinical response at week 16 and 60, respectively, and clinical remission was achieved in four patients for both time points. At week 16, a statistically significant biochemical improvement (C\u2010reactive protein and faecal calprotectin levels) was found, but this effect was no longer significant at week 60.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The clinical and radiologic improvement of perianal fistula in Crohn's disease, that was found at week 16 after treatment with hyperbaric oxygen therapy, is maintained at 1\u2010year follow\u2010up.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ueg2.12189","type":"journal-article","created":{"date-parts":[[2022,2,11]],"date-time":"2022-02-11T07:50:05Z","timestamp":1644565805000},"page":"160-168","source":"Crossref","is-referenced-by-count":36,"title":["Hyperbaric oxygen therapy for the treatment of perianal fistulas in 20 patients with Crohn's disease: Results of the HOT\u2010TOPIC trial after 1\u2010year follow\u2010up"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9395-4003","authenticated-orcid":false,"given":"Corine A.","family":"Lansdorp","sequence":"first","affiliation":[{"name":"Department of Anaesthesiology\/Hyperbaric Medicine Amsterdam UMC, Location AMC  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christianne J.","family":"Buskens","sequence":"additional","affiliation":[{"name":"Department of Surgery Amsterdam UMC, Location AMC, Amsterdam Gastroenterology Endocrinology Metabolism  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krisztina B.","family":"Gecse","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Amsterdam UMC, Location AMC  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"L\u00f6wenberg","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Amsterdam UMC, Location AMC  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaap","family":"Stoker","sequence":"additional","affiliation":[{"name":"Department of Radiology and Nuclear Medicine Amsterdam UMC, University of Amsterdam  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Willem A.","family":"Bemelman","sequence":"additional","affiliation":[{"name":"Department of Surgery Amsterdam UMC, Location AMC, Amsterdam Gastroenterology Endocrinology Metabolism  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geert R. 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