{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T06:47:19Z","timestamp":1784011639944,"version":"3.55.0"},"reference-count":33,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,2,2]],"date-time":"2022-02-02T00:00:00Z","timestamp":1643760000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002794","name":"Cancerfonden","doi-asserted-by":"publisher","award":["2018\/703"],"award-info":[{"award-number":["2018\/703"]}],"id":[{"id":"10.13039\/501100002794","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002794","name":"Cancerfonden","doi-asserted-by":"publisher","award":["2018\/735"],"award-info":[{"award-number":["2018\/735"]}],"id":[{"id":"10.13039\/501100002794","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006095","name":"Helse S\u00f8r-\u00d8st RHF","doi-asserted-by":"publisher","award":["2015051"],"award-info":[{"award-number":["2015051"]}],"id":[{"id":"10.13039\/501100006095","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006095","name":"Helse S\u00f8r-\u00d8st RHF","doi-asserted-by":"publisher","award":["2018061"],"award-info":[{"award-number":["2018061"]}],"id":[{"id":"10.13039\/501100006095","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008730","name":"Kreftforeningen","doi-asserted-by":"publisher","award":["190345"],"award-info":[{"award-number":["190345"]}],"id":[{"id":"10.13039\/100008730","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["UEG Journal"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>There is continued uncertainty regarding the risks of hepato\u2010pancreato\u2010biliary cancers in patients with inflammatory bowel disease (IBD) with or without concomitant primary sclerosing cholangitis (PSC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To give updated estimates on risk of hepato\u2010pancreato\u2010biliary cancers in patients with IBD, including pancreatic cancer, hepatocellular carcinoma, gall bladder cancer, and intra \u2013 and extrahepatic cholangiocarcinoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In a population\u2010based cohort study, we included all patients diagnosed with IBD in Norway and Sweden from 1987 to 2016. The cohort comprised of 141,960 patients, identified through hospital databases and the National Patient Register. Participants were followed through linkage to national cancer, cause of death, and population registries. We calculated absolute risk and standardized incidence ratios (SIRs) of hepato\u2010pancreato\u2010biliary cancers by PSC and other clinical characteristics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 141,960 IBD patients, 3.2% were diagnosed with PSC. During a median follow\u2010up of 10.0\u00a0years, we identified 443 biliary tract cancers (SIR 5.2, 95% confidence interval [CI] 4.8\u20135.7), 161 hepatocellular carcinomas (SIR 2.4, 95% CI 2.0\u20132.7) and 282 pancreatic cancers (SIR 1.3, 95% CI 1.2\u20131.5). The relative risks were considerably higher in PSC\u2010IBD patients, with SIR of 140 (95% CI 123\u2013159) for biliary tract, 38.6 (95% CI 29.2\u201350.0) for hepatocellular, and 9.0 (95% CI 6.3\u201312.6) for pancreatic cancer. The SIRs were still slightly increased in non\u2010PSC\u2010IBD patients, compared to the general population. For biliary tract cancer, the cumulative probability at 25\u00a0years was 15.6% in PSC\u2010IBD patients, and 0.4% in non\u2010PSC\u2010IBD patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The dramatically increased risks of hepato\u2010pancreato\u2010biliary cancers in PSC\u2010IBD patients support periodic surveillance for these malignancies. While much lower, the excess relative risks in non\u2010PSC\u2010IBD patients were not trivial compared to non\u2010IBD related risk factors.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ueg2.12204","type":"journal-article","created":{"date-parts":[[2022,2,2]],"date-time":"2022-02-02T14:28:42Z","timestamp":1643812122000},"page":"212-224","source":"Crossref","is-referenced-by-count":26,"title":["Risk of hepato\u2010pancreato\u2010biliary cancer is increased by primary sclerosing cholangitis in patients with inflammatory bowel disease: A population\u2010based cohort study"],"prefix":"10.1002","volume":"10","author":[{"given":"Jingru","family":"Yu","sequence":"first","affiliation":[{"name":"Department of Medical Epidemiology and Biostatistics Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9591-5152","authenticated-orcid":false,"given":"Erle","family":"Refsum","sequence":"additional","affiliation":[{"name":"Department of Transplantation Medicine Clinical Effectiveness Research Group Oslo University Hospital  Oslo Norway"},{"name":"Clinical Effectiveness Research Group Institute of Health and Society University of Oslo  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lise M.","family":"Helsingen","sequence":"additional","affiliation":[{"name":"Department of Transplantation Medicine Clinical Effectiveness Research Group Oslo University Hospital  Oslo Norway"},{"name":"Clinical Effectiveness Research Group Institute of Health and Society University of Oslo  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trine","family":"Folseraas","sequence":"additional","affiliation":[{"name":"Department of Transplantation Medicine Norwegian PSC Research Center Division of Surgery, Inflammatory Diseases and Transplantation Oslo University Hospital Rikshospitalet  Oslo Norway"},{"name":"Section of Gastroenterology Department of Transplantation Medicine Division of Surgery, Inflammatory Medicine and Transplantation Oslo University Hospital Rikshospitalet  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Ploner","sequence":"additional","affiliation":[{"name":"Department of Medical Epidemiology and Biostatistics Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulina","family":"Wieszczy","sequence":"additional","affiliation":[{"name":"Department of Transplantation Medicine Clinical Effectiveness Research Group Oslo University Hospital  Oslo Norway"},{"name":"Clinical Effectiveness Research Group Institute of Health and Society University of Oslo  Oslo Norway"},{"name":"Department of Gastroenterology, Hepatology and Clinical Oncology Centre of Postgraduate Medical Education  Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ishita","family":"Barua","sequence":"additional","affiliation":[{"name":"Department of Transplantation Medicine Clinical Effectiveness Research Group Oslo University Hospital  Oslo Norway"},{"name":"Clinical Effectiveness Research Group Institute of Health and Society University of Oslo  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6957-9469","authenticated-orcid":false,"given":"Henriette C.","family":"Jodal","sequence":"additional","affiliation":[{"name":"Department of Transplantation Medicine Clinical Effectiveness Research Group Oslo University Hospital  Oslo Norway"},{"name":"Clinical Effectiveness Research Group Institute of Health and Society University of Oslo  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Espen","family":"Melum","sequence":"additional","affiliation":[{"name":"Department of Transplantation Medicine Norwegian PSC Research Center Division of Surgery, Inflammatory Diseases and Transplantation Oslo University Hospital Rikshospitalet  Oslo Norway"},{"name":"Section of Gastroenterology Department of Transplantation Medicine Division of Surgery, Inflammatory Medicine and Transplantation Oslo University Hospital Rikshospitalet  Oslo Norway"},{"name":"Research Institute of Internal Medicine Division of Surgery, Inflammatory Diseases and Transplantation Oslo University Hospital  Oslo Norway"},{"name":"Institute of Clinical Medicine Faculty of Medicine University of Oslo  Oslo Norway"},{"name":"Hybrid Technology Hub\u2010Centre of Excellence Institute of Basic Medical Sciences Faculty of Medicine University of Oslo  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magnus","family":"L\u00f8berg","sequence":"additional","affiliation":[{"name":"Department of Transplantation Medicine Clinical Effectiveness Research Group Oslo University Hospital  Oslo Norway"},{"name":"Clinical Effectiveness Research Group Institute of Health and Society University of Oslo  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Blom","sequence":"additional","affiliation":[{"name":"Department of Clinical Science and Education S\u00f6dersjukhuset Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Bretthauer","sequence":"additional","affiliation":[{"name":"Department of Transplantation Medicine Clinical Effectiveness Research Group Oslo University Hospital  Oslo Norway"},{"name":"Clinical Effectiveness Research Group Institute of Health and Society University of Oslo  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans\u2010Olov","family":"Adami","sequence":"additional","affiliation":[{"name":"Department of Medical Epidemiology and Biostatistics Karolinska Institutet  Stockholm Sweden"},{"name":"Department of Transplantation Medicine Clinical Effectiveness Research Group Oslo University Hospital  Oslo Norway"},{"name":"Clinical Effectiveness Research Group Institute of Health and Society University of Oslo  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mette","family":"Kalager","sequence":"additional","affiliation":[{"name":"Department of Transplantation Medicine Clinical Effectiveness Research Group Oslo University Hospital  Oslo Norway"},{"name":"Clinical Effectiveness Research Group Institute of Health and Society University of Oslo  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weimin","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Medical Epidemiology and Biostatistics Karolinska Institutet  Stockholm Sweden"},{"name":"Department of Epidemiology and Health Statistics\u00a0&amp; Key Laboratory of Ministry of Education for Gastrointestinal Cancer Fujian Medical University  Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,2,2]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)32448-0"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-009-9365-4"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2020.05.049"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.23666"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2013.03.034"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.15785"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2020.08.015"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19910401)67:7<2015::AID-CNCR2820670731>3.0.CO;2-R"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2004.01858.x"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2013.249"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365521.2013.846402"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(20010215)91:4<854::AID-CNCR1073>3.0.CO;2-Z"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21492"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2021.08.032"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpg.2010.07.005"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11894-018-0620-2"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(20)30005-4"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)32545-0"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2015-311003"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365521.2016.1246605"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2005.082909"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.3109\/0284186X.2013.857429"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.28775"},{"issue":"5","key":"e_1_2_12_25_1","first-page":"571","article-title":"Malignancies in patients with inflammatory bowel disease: results from 20 Years of follow\u2010up in the IBSEN study","volume":"11","author":"Hovde O","year":"2017","journal-title":"J Crohns Colitis"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjx040"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.13548"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crohns.2014.01.019"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2017.02.038"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-20-1241"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23294"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.51.suppl_6.vi1"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.06.021"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.3109\/0284186X.2011.599338"}],"container-title":["United European Gastroenterology Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ueg2.12204","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ueg2.12204","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ueg2.12204","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,27]],"date-time":"2023-08-27T12:50:59Z","timestamp":1693140659000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ueg2.12204"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,2]]},"references-count":33,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,3]]}},"alternative-id":["10.1002\/ueg2.12204"],"URL":"https:\/\/doi.org\/10.1002\/ueg2.12204","archive":["Portico"],"relation":{},"ISSN":["2050-6406","2050-6414"],"issn-type":[{"value":"2050-6406","type":"print"},{"value":"2050-6414","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,2,2]]}}}