{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T04:17:00Z","timestamp":1789186620483,"version":"build-2803163510"},"reference-count":22,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,4,5]],"date-time":"2022-04-05T00:00:00Z","timestamp":1649116800000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["32003B_160115"],"award-info":[{"award-number":["32003B_160115"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["32003B_204751\/1"],"award-info":[{"award-number":["32003B_204751\/1"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["P2ZHP3_168561"],"award-info":[{"award-number":["P2ZHP3_168561"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U54 AI117804 CEGIR training grant"],"award-info":[{"award-number":["U54 AI117804 CEGIR training grant"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["UEG Journal"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and aims<\/jats:title>\n                    <jats:p>No recommendations exist regarding optimal follow\u2010up schedule in patients with eosinophilic esophagitis (EoE) under maintenance treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively evaluated a long\u2010term surveillance concept at the Swiss EoE clinic, where clinical, endoscopic and histological disease activity is assessed annually regardless of EoE symptoms. Data on 159 adult patients under maintenance steroid treatment with available follow\u2010up were analyzed. Patients were classified as having close (duration between visits &lt;18\u00a0months) or non\u2010close follow\u2010up (\u226518\u00a0months).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We analyzed a total of 309 follow\u2010up visits of 159 patients (123 males, age at diagnosis 38.9\u00a0\u00b1\u00a015.4\u00a0years). 157 (51%) visits were within a close follow\u2010up schedule (median duration between visits of 1.0\u00a0years (interquartile range (IQR) 0.9\u20131.2)), while 152 visits (49%) were not (median duration between visits 2.9\u00a0years (IQR 2.0\u20134.1)). There was no difference regarding ongoing clinical, endoscopic, and histological disease activity, and adherence to prescribed steroid treatment between the two groups. However, stricture formation was significantly less frequently observed at visits within a close follow\u2010up schedule (22.9 vs. 33.6%,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.038). Absence of close follow\u2010up was a significant risk factor for stricture development in a multivariate regression model. Patients who achieved histological remission and were followed within a close\u2010follow\u2010up schedule had significantly earlier detection of histological relapse compared to patients not within such close follow\u2010up.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Close follow\u2010up is associated with fewer stricture formation and appears to result in earlier detection of histological relapse in patients with eosinophilic esophagitis. We advocate for regular assessment of disease activity (every 12\u201318\u00a0months) in order to detect relapsing disease as early as possible, and therefore potentially minimize the risk for EoE complications.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ueg2.12216","type":"journal-article","created":{"date-parts":[[2022,4,6]],"date-time":"2022-04-06T01:47:32Z","timestamp":1649209652000},"page":"308-318","source":"Crossref","is-referenced-by-count":40,"title":["Close follow\u2010up is associated with fewer stricture formation and results in earlier detection of histological relapse in the long\u2010term management of eosinophilic esophagitis"],"prefix":"10.1002","volume":"10","author":[{"given":"Lorenz","family":"Bon","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology University Hospital Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ekaterina","family":"Safroneeva","sequence":"additional","affiliation":[{"name":"Institute of Social and Preventive Medicine University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Bussmann","sequence":"additional","affiliation":[{"name":"Pathology Viollier AG  Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luc","family":"Biedermann","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology University Hospital Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1610-1925","authenticated-orcid":false,"given":"Philipp","family":"Schreiner","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology University Hospital Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan R.","family":"Vavricka","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology University Hospital Zurich  Zurich Switzerland"},{"name":"Center for Gastroenterology and Hepatology  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain M.","family":"Schoepfer","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology University Hospital Lausanne \u2013 Centre Hopitalier Universitaire Vaudois (CHUV)  Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Talaya","family":"McCright\u2010Gill","sequence":"additional","affiliation":[{"name":"Mount Sinai Center for Eosinophilic Disorders Icahn School of Medicine at Mount Sinai  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans\u2010Uwe","family":"Simon","sequence":"additional","affiliation":[{"name":"Institute of Biochemistry Medical School Brandenburg  Neuruppin Germany"},{"name":"Institute of Pharmacology University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Straumann","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology University Hospital Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirna","family":"Chehade","sequence":"additional","affiliation":[{"name":"Mount Sinai Center for Eosinophilic Disorders Icahn School of Medicine at Mount Sinai  New York New York 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