{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T20:55:50Z","timestamp":1790110550737,"version":"4.0.1"},"reference-count":53,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,5,16]],"date-time":"2022-05-16T00:00:00Z","timestamp":1652659200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["Juan Rodes grant (JR19\/00005)"],"award-info":[{"award-number":["Juan Rodes grant (JR19\/00005)"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["Sara Borrell grant (CD19\/00102)"],"award-info":[{"award-number":["Sara Borrell grant (CD19\/00102)"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["UEG Journal"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Poor adherence to clinical practice guidelines for eosinophilic esophagitis (EoE) has been described and the diagnostic delay of the disease continues to be unacceptable in many settings.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To analyze the impact of improved knowledge provided by the successive international clinical practice guidelines on reducing diagnostic delay and improving the diagnostic process for European patients with EoE.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Cross\u2010sectional analysis of the EoE CONNECT registry based on clinical practice. Time periods defined by the publication dates of four major sets of guidelines over 10 years were considered. Patients were grouped per time period according to date of symptom onset.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Data from 1,132 patients was analyzed and median (IQR) diagnostic delay in the whole series was 2.1 (0.7\u20106.2) years. This gradually decreased over time with subsequent release of new guidelines (p &lt; 0.001), from 12.7 years up to 2007 to 0.7 years after 2017. The proportion of patients with stricturing of mixed phenotypes at the point of EoE diagnosis also decreased over time (41.3% vs. 16%; p &lt; 0.001), as did EREFS scores. The fibrotic sub\u2010score decreased from a median (IQR) of 2 (1\u20102) to 0 (0\u20101) when patients whose symptoms started up to 2007 and after 2017 were compared (p &lt; 0.001). In parallel, symptoms measured with the Dysphagia Symptoms Score reduced significantly when patients with symptoms starting before 2007 and after 2012 were compared. A reduction in the number of endoscopies patients underwent before the one that achieved an EoE diagnosis, and the use of allergy testing as part of the diagnostic workout of EoE, also reduced significantly over time (p = 0.010 and p &lt; 0.001, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The diagnostic work\u2010up of EoE patients improved substantially over time at the European sites contributing to EoE CONNECT, with a dramatic reduction in diagnostic delay.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ueg2.12240","type":"journal-article","created":{"date-parts":[[2022,5,17]],"date-time":"2022-05-17T05:20:08Z","timestamp":1652764808000},"page":"507-517","source":"Crossref","is-referenced-by-count":40,"title":["Accurate and timely diagnosis of Eosinophilic Esophagitis improves over time in Europe. An analysis of the EoE CONNECT Registry"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6293-2570","authenticated-orcid":false,"given":"Pilar","family":"Navarro","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Hospital General de Tomelloso  Tomelloso Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria La Princesa  Madrid Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria de Castilla\u2010La Mancha (IDISCAM)  Tomelloso Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9039-7667","authenticated-orcid":false,"given":"Emilio J","family":"Laserna\u2010Mendieta","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Hospital General de Tomelloso  Tomelloso Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria La Princesa  Madrid Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria de Castilla\u2010La Mancha (IDISCAM)  Tomelloso Spain"},{"name":"Laboratory Medicine Department. Hospital Universitario de La Princesa  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"Casabona","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n Sanitaria La Princesa  Madrid Spain"},{"name":"Department of Gastroenterology Hospital Universitario de La Princesa  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3187-2894","authenticated-orcid":false,"given":"Edoardo","family":"Savarino","sequence":"additional","affiliation":[{"name":"Department of Surgery Oncology and Gastroenterology Gastroenterology Unit Azienza Ospedaliera di Padova  Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Teresa","family":"P\u00e9rez\u2010Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n Sanitaria La Princesa  Madrid Spain"},{"name":"Department of Gastroenterology Hospital Universitario de La Princesa  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6026-5639","authenticated-orcid":false,"given":"Matteo","family":"Ghisa","sequence":"additional","affiliation":[{"name":"Department of Surgery Oncology and Gastroenterology Gastroenterology Unit Azienza Ospedaliera di Padova  Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2535-1929","authenticated-orcid":false,"given":"Isabel","family":"P\u00e9rez\u2010Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Hospital Universitario Central de Asturias  Oviedo Spain"},{"name":"Diet Microbiota and Health Group. 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