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A Delphi consensus was performed with experts from 10 European countries who conducted a literature summary and voting process on 31 statements. Quality of evidence was evaluated using the grading of recommendations, assessment, development, and evaluation criteria. Consensus (defined as &gt;80% agreement) was reached for all the statements. The panel agreed with the potential overlapping of IBS\u2010D and FDr. In terms of diagnosis, the consensus supports a symptom\u2010based approach also with the exclusion of alarm symptoms, recommending the evaluation of full blood count, C\u2010reactive protein, serology for coeliac disease, and faecal calprotectin, and consideration of diagnosing bile acid diarrhoea. Colonoscopy with random biopsies in both the right and left colon is recommended in patients older than 50\u00a0years and in presence of alarm features. Regarding treatment, a strong consensus was achieved for the use of a diet low fermentable oligo\u2010, di\u2010, monosaccharides and polyols, gut\u2010directed psychological therapies, rifaximin, loperamide, and eluxadoline. A weak or conditional recommendation was achieved for antispasmodics, probiotics, tryciclic antidepressants, bile acid sequestrants, 5\u2010hydroxytryptamine\u20103 antagonists (i.e. alosetron, ondansetron, or ramosetron). A multinational group of European experts summarized the current state of consensus on the definition, diagnosis, and management of IBS\u2010D and FDr.<\/jats:p>","DOI":"10.1002\/ueg2.12259","type":"journal-article","created":{"date-parts":[[2022,6,13]],"date-time":"2022-06-13T13:31:49Z","timestamp":1655127109000},"page":"556-584","source":"Crossref","is-referenced-by-count":144,"title":["Functional bowel disorders with diarrhoea: Clinical guidelines of the United European Gastroenterology and European Society for Neurogastroenterology and Motility"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3187-2894","authenticated-orcid":false,"given":"Edoardo","family":"Savarino","sequence":"first","affiliation":[{"name":"Gastroenterology Unit Department of Surgery, Oncology and Gastroenterology University of Padua  Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabiana","family":"Zingone","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit Department of Surgery, Oncology and Gastroenterology University of Padua  Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brigida","family":"Barberio","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit Department of Surgery, Oncology and Gastroenterology University of Padua  Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Marasco","sequence":"additional","affiliation":[{"name":"Division of Internal Medicine IRCCS Azienda Ospedaliero\u2010Universitaria di Bologna  Bologna Italy"},{"name":"Department of Medical and Surgical Sciences University of Bologna  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filiz","family":"Akyuz","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology \u0130stanbul University \u0130stanbul School of Medicine  \u0130stanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hale","family":"Akpinar","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Dokuz Eyl\u00fcl University School of Medicine  Izmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oana","family":"Barboi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology \u2018Grigore T. 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