{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T01:55:36Z","timestamp":1792029336141,"version":"4.4.0"},"reference-count":47,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2022,7,6]],"date-time":"2022-07-06T00:00:00Z","timestamp":1657065600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["UEG Journal"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Health\u2010related Quality of life (HRQoL) in patients with Barrett's esophagus (BE), a premalignant condition, may be influenced by gastroesophageal reflux disease (GERD) symptoms and the risk of developing esophageal adenocarcinoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We aim to investigate HRQoL in non\u2010dysplastic Barrett Esophagus (NDBE) patients, identify factors associated with <jats:bold>a negative illness perception<\/jats:bold> of the diagnosis BE and compare outcomes between patients treated in a specialized BE center with non\u2010expert centers. In this multi\u2010center cross\u2010sectional study, HRQoL of NDBE patients were assessed using the Short Form 36, Hospital Anxiety and Depression Scale, Cancer worry Scale, and Reflux Disease Questionnaire. A multivariable, linear regression analysis was conducted to assess factors associated with <jats:bold>illness perception (Illness perception scale)<\/jats:bold> of the BE diagnosis. Outcome parameters of patients from expert centers were compared to non\u2010expert centers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 859 NDBE patients <jats:bold>(mean age 63.6% and 74.5% male)<\/jats:bold>, of which 640 from BE expert centers were included. BE patients scored similar or higher means (i.e. better) on generic HRQoL in comparison with a Dutch norm population. The multivariable regression model showed that cancer worry, GERD symptoms, signs of anxiety and depression, and female gender were associated with <jats:bold>a negative illness perception<\/jats:bold> of BE. GERD symptoms were reported in the minority (22.4%) of BE patients. Levels of anxiety symptoms were comparable to a Dutch norm population (mean 3.7 vs. 3.9 <jats:italic>p<\/jats:italic> 0.183) and lower for depression symptoms (mean 6.8 vs. 7.6 <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001). Overall, there were no differences found on outcomes between expert centers and non\u2010expert centers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>NDBE patients scored similar or better on generic HRQoL, anxiety and depression than an age and gender matched norm population. The presence of cancer worry, gastrointestinal symptoms, anxiety and depression, and female gender are factors associated with <jats:bold>a negative illness perception<\/jats:bold> of the diagnosis BE.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ueg2.12266","type":"journal-article","created":{"date-parts":[[2022,7,7]],"date-time":"2022-07-07T06:40:21Z","timestamp":1657176021000},"page":"721-729","source":"Crossref","is-referenced-by-count":11,"title":["Barrett Esophagus: Quality of life and factors associated with illness perception"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3403-3524","authenticated-orcid":false,"given":"Mirjam C. 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H.","family":"Scheffer","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Jeroen Bosch Hospital  \u2018s Hertogenbosch the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rogier J. J.","family":"de Ridder","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Maastricht UMC+  Maastricht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4707-1186","authenticated-orcid":false,"given":"Roos E.","family":"Pouw","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Amsterdam UMC Location Vrije Universiteit Amsterdam  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alaa","family":"Alkhalaf","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Isala Hospital  Zwolle the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bas L. A. 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