{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T19:28:25Z","timestamp":1789586905042,"version":"build-2803163510"},"reference-count":19,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2022,9,10]],"date-time":"2022-09-10T00:00:00Z","timestamp":1662768000000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["UEG Journal"],"published-print":{"date-parts":[[2022,9]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n The size of gallbladder (GB) polyps is a representative risk factor for neoplastic polyps. However, whether growth rate during follow\u2010up is associated with neoplastic polyps remains unclear.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n From 2009 to 2019, a cohort of patients with GB polyps who underwent cholecystectomy was enrolled. We included only patients who underwent at least two abdominal ultrasonography procedures at least 6\u00a0months apart prior to cholecystectomy. Performance and optimal cutoff value of polyp growth rate for predicting neoplastic polyps were estimated using receiver operating characteristic (ROC) analysis. In addition to growth rate, several other variables considered suitable for predicting neoplastic polyps were also investigated. A nomogram was created to predict neoplastic polyps.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n A total of 239 patients with neoplastic polyps (\n n<\/jats:italic>\n \u00a0=\u00a027, 11.3%) and non\u2010neoplastic polyps (\n n<\/jats:italic>\n \u00a0=\u00a0212, 88.7%) were included. The median follow\u2010up period was 28.5\u00a0months. The area under the ROC curve (AUROC) of polyp growth rate for neoplastic polyps was 0.66 (95% confidence interval, 0.59\u20130.72). The growth rate cutoff value for prediction of neoplastic polyps was 3\u00a0mm\/year (sensitivity, 37.0%; specificity, 86.3%). Multivariate analysis identified several factors predicting neoplastic polyps: polyp size \u226510\u00a0mm (odds ratio [OR], 3.74,\n p<\/jats:italic>\n \u00a0=\u00a00.041), solitary polyp (OR, 3.92,\n p<\/jats:italic>\n \u00a0=\u00a00.004), and polyp growth rate \u2265 3\u00a0mm\/year (OR, 2.75,\n p<\/jats:italic>\n \u00a0=\u00a00.031). The AUROC of the nomogram using these three significant factors in multivariate analysis was 0.71.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n GB polyps with a growth rate of over 3\u00a0mm per year on ultrasonography during follow\u2010up should be considered a risk factor for neoplastic polyps.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/ueg2.12274","type":"journal-article","created":{"date-parts":[[2022,9,10]],"date-time":"2022-09-10T07:38:59Z","timestamp":1662795539000},"page":"651-656","source":"Crossref","is-referenced-by-count":13,"title":["Gallbladder polyps growth rate is an independent risk factor for neoplastic polyps"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1456-1450","authenticated-orcid":false,"given":"Ji Won","family":"Han","sequence":"first","affiliation":[{"name":"Department of Internal Medicine College of Medicine The Catholic University of Korea Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Hoon","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine College of Medicine The Catholic University of Korea Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"In Seok","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine College of Medicine The Catholic University of Korea Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ho Joong","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Surgery College of Medicine The Catholic University of Korea Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tae Ho","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Surgery College of Medicine The Catholic University of Korea Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Kyoung","family":"You","sequence":"additional","affiliation":[{"name":"Department of Surgery College of Medicine The Catholic University of Korea Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,9,10]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00423\u2010015\u20101302\u20102"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365521.1990.12067104"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2003.11.043"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440\u20101746.2008.05689.x"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330\u2010017\u20105175\u20103"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surge.2014.01.003"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330\u2010017\u20104742\u2010y"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.2012.1948"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/mcg.0b013e31819359aa"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.46.2.250"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365521.2021.1970220"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surge.2015.12.001"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v17.i17.2216"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.14080"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2009.24.3.481"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajum.12284"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00464\u2010018\u20106444\u20101"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658\u2010199904000\u201000008"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2008.10.017"}],"container-title":["United 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