{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T10:31:15Z","timestamp":1770546675163,"version":"3.49.0"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,11,28]],"date-time":"2022-11-28T00:00:00Z","timestamp":1669593600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["UEG Journal"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and aims<\/jats:title><jats:p>Hepatorenal syndrome is a major complication in patients with cirrhosis and associated with high mortality. Predictive biomarkers for therapy response are largely missing. Cytokeratin18\u2010based cell death markers are significantly elevated in patients with complications of chronic liver disease, but the role of these markers in patients with HRS treated with vasoconstrictors and albumin is unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We prospectively analyzed a total of 138 patients with HRS, liver cirrhosis without HRS and acute kidney injury treated at the University Medical Center Mainz between April 2013 and July 2018. Serum levels of M30 and M65 were analyzed by ELISA and clinical data were collected. Predictive ability was assessed by Kaplan\u2010Meier curves, logistic regression and c\u2010statistic. Primary endpoint was response to therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>M30 and M65 were significantly increased in patients with HRS compared to non\u2010HRS controls (M30: <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.0001; M65: <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.0001). Both serum markers showed predictive ability for dialysis\u2010 and LTX\u2010free survival but not overall survival. Logistic regression confirmed M30 and M65 as independent prognostic factors for response to therapy. A novel predictive score comprising bilirubin and M65 showed highest predictive ability to predict therapy response.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Serum levels of M30 and M65 can robustly discriminate patients into responders and non\u2010responders to terlipressin therapy with a good predictive ability for dialysis\u2010 and LTX\u2010free survival in cirrhotic patients. Cell death parameters might possess clinical relevance in patients with liver cirrhosis and HRS.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ueg2.12337","type":"journal-article","created":{"date-parts":[[2022,11,28]],"date-time":"2022-11-28T15:41:01Z","timestamp":1669650061000},"page":"92-102","source":"Crossref","is-referenced-by-count":4,"title":["Markers of cell death predict therapy response in patients with cirrhosis and hepatorenal syndrome"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3650-2921","authenticated-orcid":false,"given":"Sophia","family":"Heinrich","sequence":"first","affiliation":[{"name":"Department of Medicine I University Medical Center  Mainz Germany"},{"name":"Clinic for Gastroenterology Hepatology and Endocrinology Hannover Medical School  Hannover Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Austgen","sequence":"additional","affiliation":[{"name":"Department of Medicine I 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