{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T11:03:49Z","timestamp":1792839829382,"version":"4.5.0"},"reference-count":31,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,6,5]],"date-time":"2023-06-05T00:00:00Z","timestamp":1685923200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001254","name":"Ipsen Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001254","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["UEG Journal"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aims<\/jats:title><jats:p>Polycystic liver disease (PLD) can lead to extensive hepatomegaly. Symptom relief is the primary goal of the treatment. The role of the recently developed disease\u2010specific questionnaires for identification of the thresholds and the assessment of therapy needs further investigation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A five\u2010year prospective multi\u2010centric observational study in 21 hospitals in Belgium gathered a study population of 198 symptomatic PLD\u2010patients of whom the disease\u2010specific symptom questionnaire PLD\u2010complaint\u2010specific assessment (POLCA) scores were calculated. The thresholds of the POLCA score for the need for volume reduction therapy were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study group consisted of mostly (82.8%) women with baseline mean age of 54.4\u00a0years \u00b111.2, median liver volume expressed as height\u2010adjusted total liver volume(htLV) of 1994\u00a0mL (interquartile range [IQR] 1275; 3150) and median growth of the liver of +74\u00a0mL\/year (IQR +3; +230). Volume reduction therapy was needed in 71 patients (35.9%). A POLCA severity score (SPI)\u00a0\u2265\u00a014 predicted the need for therapy both in the derivation (<jats:italic>n<\/jats:italic>\u00a0=\u00a063) and the validation cohort (<jats:italic>n<\/jats:italic>\u00a0=\u00a0126). The thresholds to start somatostatin analogues (<jats:italic>n<\/jats:italic>\u00a0=\u00a055) or to consider liver transplantation (<jats:italic>n<\/jats:italic>\u00a0=\u00a018) were SPI scores of \u226514 and\u00a0\u2265\u00a018 and the corresponding mean htLVs were 2902\u00a0mL (IQR 1908; 3964) and 3607\u00a0mL (IQR 2901; 4337), respectively. Somatostatin analogues treatment resulted in a decrease in the SPI score \u22126.0 versus\u00a0+\u00a04.5 in patients without somatostatin analogues (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.01). Changes in the SPI score were significantly different between the liver transplantation group and no liver transplantation group, +4.3\u00a0\u00b1\u00a07.1 versus \u22121.6\u00a0\u00b1\u00a04.9, respectively, (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A polycystic liver disease\u2010specific questionnaire can be used as a guide on when to start a volume reduction therapy and to assess the effect of treatment.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ueg2.12387","type":"journal-article","created":{"date-parts":[[2023,6,7]],"date-time":"2023-06-07T08:39:15Z","timestamp":1686127155000},"page":"633-641","source":"Crossref","is-referenced-by-count":6,"title":["Questionnaire PLD\u2010complaint\u2010specific assessment identifies need for therapy in polycystic liver disease: A multi\u2010centric prospective study"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9086-9305","authenticated-orcid":false,"given":"Antoon","family":"Billiet","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology University Hospitals KU Leuven European Reference Network on liver disease (ERN Rare\u2010Liver)  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederik","family":"Temmerman","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology University Hospitals KU Leuven European Reference Network on liver disease (ERN Rare\u2010Liver)  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter","family":"Coudyzer","sequence":"additional","affiliation":[{"name":"Department of Radiology University Hospitals KU Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie","family":"Van den Ende","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology University Hospitals KU Leuven European Reference Network on liver disease (ERN Rare\u2010Liver)  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Colle","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Algemeen Stedelijk Ziekenhuis Aalst  Aalst Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sven","family":"Francque","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Antwerp University Hospital  Antwerp Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephane","family":"De Maeght","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Grand H\u00f4pital De Charleroi Saint\u2010Joseph  Charleroi 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