{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T13:21:10Z","timestamp":1789651270956,"version":"4.0.0"},"reference-count":38,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,5,4]],"date-time":"2023-05-04T00:00:00Z","timestamp":1683158400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["UEG Journal"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Patients with inflammatory bowel disease are at increased risk of colorectal and extra\u2010intestinal cancer. However, the overall cancer risk in patients with Crohn's disease (CD) with perianal fistulas (PF) (CPF) and those with CD without PF (non\u2010PF CD) is unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To describe the prevalence and incidence of cancer in patients with CPF and non\u2010PF CD, and to estimate incidence rate ratio (IRR) of cancer between CPF and non\u2010PF CD groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective cohort study was conducted using the German InGef (Institute for Applied Health Research Berlin) research database. Patients with a CD record and PF from 1 January 2013 to 31 December 2014 were identified and followed up from 1 January 2015 until the first occurrence of cancer, end of health insurance contributing data, death, or end of study period (31 December 2020). Prevalence of any type of cancer including patients with CD diagnosed with cancer in the selection period and incidence of cancer excluding patients with CD diagnosed with cancer in the selection period were calculated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, 10,208 patients with CD were identified. Of 824 patients with CPF (8.1%), 67 had had a malignancy (6\u2010year period crude malignancy prevalence 8.13% [95% confidence interval (CI) 6.36%\u201310.21%]), which was lower than patients with non\u2010PF CD (19.8% [95% CI 19%\u201320.6%]). Incidence (per 100,000 person\u2010years) in patients with CPF was 1184 (95% CI 879\u20131561) and in non\u2010PF CD was 2365 (95% CI 2219\u20132519). There was no significant difference in the adjusted IRR of cancer for the CPF group compared with the non\u2010PF CD group (0.83 [95% CI 0.62\u20131.10]; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.219).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>There was no significant difference in the incidence of any cancer in patients with CPF compared with non\u2010PF CD. However, patients with CPF had a higher numerical risk of cancer than the general German population.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ueg2.12396","type":"journal-article","created":{"date-parts":[[2023,5,4]],"date-time":"2023-05-04T13:53:30Z","timestamp":1683208410000},"page":"520-530","source":"Crossref","is-referenced-by-count":2,"title":["Malignancy rates in Crohn's disease patients with perianal fistula: A German retrospective cohort study"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6627-0378","authenticated-orcid":false,"given":"B\u00e9l\u00e8ne","family":"Podmore","sequence":"first","affiliation":[{"name":"OXON Epidemiology  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominik","family":"Beier","sequence":"additional","affiliation":[{"name":"InGef \u2013 Institute for Applied Health Research Berlin GmbH  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan","family":"Burisch","sequence":"additional","affiliation":[{"name":"Gastrounit, Medical Division Copenhagen University Hospital  Amager and Hvidovre Denmark"},{"name":"Copenhagen Center for Inflammatory Bowel Disease in Children Adolescents and Adults Copenhagen University Hospital \u2013 Amager and Hvidovre  Hvidovre Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"Genestin","sequence":"additional","affiliation":[{"name":"Takeda Pharmaceuticals International AG  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis","family":"Haeckl","sequence":"additional","affiliation":[{"name":"WIG2 GmbH  Leipzig Germany"},{"name":"Faculty of Economics and Management Science Leipzig University  Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"Nagel","sequence":"additional","affiliation":[{"name":"InGef \u2013 Institute for Applied Health Research Berlin GmbH  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nawab","family":"Qizilbash","sequence":"additional","affiliation":[{"name":"OXON Epidemiology  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Schwartz","sequence":"additional","affiliation":[{"name":"Vanderbilt University Medical Center in Nashville  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan R.","family":"Vavricka","sequence":"additional","affiliation":[{"name":"Center of Gastroenterology and Hepatology  Z\u00fcrich Switzerland"},{"name":"Department of Gastroenterology and Hepatology University Hospital  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8387-9342","authenticated-orcid":false,"given":"Dimitri","family":"Bennett","sequence":"additional","affiliation":[{"name":"Takeda Development Center Americas, Inc.  Cambridge Massachusetts USA"},{"name":"Perelman School of Medicine University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9724-054X","authenticated-orcid":false,"given":"Axel","family":"Dignass","sequence":"additional","affiliation":[{"name":"Department of Medicine I Agaplesion Markus Hospital  Frankfurt Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,5,4]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000509544"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco\u2010jcc\/jjaa118"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2009.760"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2020.08.015"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102036.2004.01858.x"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/ibd\/izab198"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12955\u2010020\u201001622\u20107"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/ibd\/izy247"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v24.i42.4821"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/codi.13286"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gtc.2014.05.010"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/MIB.0000000000000243"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/ibd\/izaa340"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v22.i20.4794"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2021.04.007"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.15308"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco\u2010jcc\/jjab057"},{"key":"e_1_2_10_19_1","first-page":"521","article-title":"Perianal fistulas in patients with Crohn's disease, Part 2: surgical, endoscopic, and future therapies","volume":"14","author":"Gold SL","year":"2018","journal-title":"Gastroenterol Hepatol"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2011.00098"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.20524\/aog.2016.0099"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10350\u2010005\u20100052\u20106"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00384\u2010012\u20101581\u20109"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(16)31203\u2010X"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2017.12.020"},{"key":"e_1_2_10_26_1","unstructured":"European Medicines Agency.Assessment report: Alofisel;2017.https:\/\/www.ema.europa.eu\/en\/documents\/assessment\u2010report\/alofisel\u2010epar\u2010public\u2010assessment\u2010report_en.pdf"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.puhe.2022.02.013"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.3895"},{"key":"e_1_2_10_29_1","unstructured":"Gesund\u2010heits\u2010bericht\u2010erstat\u2010tungdB.Standard populations used for age standardization in the information system of the Federal Health Monitoring."},{"key":"e_1_2_10_30_1","unstructured":"Robert Koch Institute.The association of population\u2010based cancer registries in Germany. Cancer in Germany 2017\/2018."},{"key":"e_1_2_10_31_1","unstructured":"StatistischeBD.Database of the federal statistical Office of Germany. Accessed October 2022."},{"key":"e_1_2_10_32_1","unstructured":"Cancer Today. IARC.Estimated number of new cases in 2020 Germany both sexes all ages. Global Cancer Observatory;2020.https:\/\/gco.iarc.fr\/today\/online\u2010analysis\u2010table"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdn595"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2013.03.034"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco\u2010jcc\/jjv141"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2017.11.041"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/bf02560444"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/ctg.2016.8"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.14336\/AD.2017.0103"}],"container-title":["United European Gastroenterology Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ueg2.12396","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,18]],"date-time":"2023-08-18T05:23:00Z","timestamp":1692336180000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ueg2.12396"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,4]]},"references-count":38,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2023,7]]}},"alternative-id":["10.1002\/ueg2.12396"],"URL":"https:\/\/doi.org\/10.1002\/ueg2.12396","archive":["Portico"],"relation":{},"ISSN":["2050-6406","2050-6414"],"issn-type":[{"value":"2050-6406","type":"print"},{"value":"2050-6414","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,4]]}}}