{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T00:09:16Z","timestamp":1790899756726,"version":"4.1.0"},"reference-count":45,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,6,15]],"date-time":"2023-06-15T00:00:00Z","timestamp":1686787200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100014219","name":"National Science Fund for Distinguished Young Scholars","doi-asserted-by":"publisher","award":["81825024"],"award-info":[{"award-number":["81825024"]}],"id":[{"id":"10.13039\/501100014219","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["UEG Journal"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Consensus guidelines recommend the use of multiple antiemetics as prophylaxis in patients at high risk of postoperative nausea and vomiting (PONV), but the evidence regarding combining acupuncture and antiemetics as a multimodal approach was of very low quality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>This study aimed to assess the effect of combinations of acupuncture with ondansetron versus ondansetron alone for PONV prophylaxis in women at a high risk.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This parallel, randomised controlled trial was conducted in a tertiary hospital in China. Patients who had three or four PONV risk factors on the Apfel simplified risk score, undergoing elective laparoscopic gynaecological surgery for benign pathology, were recruited. Patients in the combination group received two sessions of acupuncture treatment and 8\u00a0mg intravenous ondansetron, whereas those in the ondansetron group received ondansetron alone. The primary outcome was the incidence of PONV within 24\u00a0h postoperatively. Secondary outcomes included the incidence of postoperative nausea, postoperative vomiting, adverse events etc.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Between January and July 2021, a total of 212 women were recruited, 91 patients in the combination group and 93 patients in the ondansetron group were included in the modified intention\u2010to\u2010treat analysis. In the first 24\u00a0h postoperatively, 44.0% of the patients in the combination group and 60.2% of the patients in the ondansetron group experienced nausea, vomiting, or both (difference, \u221216.3% [95% CI, \u221230.5 to \u22122.0]; risk ratio, 0.73 [95% CI, 0.55\u20130.97]; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.03). However, the results of the secondary outcomes showed that compared to ondansetron alone, acupuncture together with ondansetron was only effective in reducing nausea but did not have a significant impact on vomiting. The incidence of adverse events was similar between the groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Acupuncture combined with ondansetron as a multimodal prophylaxis approach is more effective than ondansetron alone in preventing postoperative nausea in high\u2010risk patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ueg2.12421","type":"journal-article","created":{"date-parts":[[2023,6,15]],"date-time":"2023-06-15T11:51:30Z","timestamp":1686829890000},"page":"564-575","source":"Crossref","is-referenced-by-count":30,"title":["Acupuncture combined with ondansetron for prevention of postoperative nausea and vomiting in high\u2010risk patients undergoing laparoscopic gynaecological surgery: A\u00a0randomised controlled trial"],"prefix":"10.1002","volume":"11","author":[{"given":"Shiyan","family":"Yan","sequence":"first","affiliation":[{"name":"International Acupuncture and Moxibustion Innovation Institute School of Acupuncture\u2010Moxibustion and Tuina Beijing University of Chinese Medicine  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingjun","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology Beijing Obstetrics and Gynaecology Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuan","family":"Zou","sequence":"additional","affiliation":[{"name":"International Acupuncture and Moxibustion Innovation Institute School of Acupuncture\u2010Moxibustion and Tuina Beijing University of Chinese Medicine  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyi","family":"Xiong","sequence":"additional","affiliation":[{"name":"International Acupuncture and Moxibustion Innovation Institute School of Acupuncture\u2010Moxibustion and Tuina Beijing University of Chinese Medicine  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hewen","family":"Li","sequence":"additional","affiliation":[{"name":"International Acupuncture and Moxibustion Innovation Institute School of Acupuncture\u2010Moxibustion and Tuina Beijing University of Chinese Medicine  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingwen","family":"Yang","sequence":"additional","affiliation":[{"name":"International Acupuncture and Moxibustion Innovation Institute School of Acupuncture\u2010Moxibustion and Tuina Beijing University of Chinese Medicine  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenchao","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology Beijing Obstetrics and Gynaecology Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziqiong","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology Beijing Obstetrics and Gynaecology Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8031-5667","authenticated-orcid":false,"given":"Cunzhi","family":"Liu","sequence":"additional","affiliation":[{"name":"International Acupuncture and Moxibustion Innovation Institute School of Acupuncture\u2010Moxibustion and Tuina Beijing University of Chinese Medicine  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,6,15]]},"reference":[{"issue":"42","key":"e_1_2_13_2_1","first-page":"733","article-title":"Nausea and vomiting after surgery under general anesthesia: an evidence\u2010based review concerning risk assessment, prevention, and treatment","volume":"107","author":"R\u00fcsch D","year":"2010","journal-title":"Dtsch Arztebl Int"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aes276"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200004000-00007"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/bf03012088"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199909000-00022"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1213\/00000539-199603000-00019"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1213\/ane.0000000000004833"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinane.2021.110437"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.anes.0000290617.98058.d9"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.cd007598.pub3"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000539-200204000-00018"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aew375"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1213\/01.ane.0000130355.91214.9e"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1213\/01.ane.0000189217.19600.5c"},{"issue":"4","key":"e_1_2_13_16_1","first-page":"973","article-title":"Whether does acupressure (P6) prevent nausea and vomiting in patients undergoing laparoscopic surgery","volume":"6","author":"Iqbal U","year":"2012","journal-title":"Pakistan J Med Health Sci"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.5812\/aapm.12876"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.cd003281.pub4"},{"issue":"04","key":"e_1_2_13_19_1","first-page":"325","article-title":"Acupoint selection rules of acupuncture for postoperative nausea and vomiting","volume":"36","author":"Shi Y","year":"2016","journal-title":"Jilin J Traditional Chin Med"},{"issue":"06","key":"e_1_2_13_20_1","first-page":"596","article-title":"Expert consensus for acupoint stimulation in preventing postoperative nausea and vomiting","volume":"35","author":"Anesthesiology CSOI","year":"2019","journal-title":"J Clin Anesthesiology"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1213\/ane.0000000000004730"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.j1455"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199207000-00023"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/aln.0000000000002133"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.cd012859.pub2"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.5114\/aoms.2019.83293"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/eja.0b013e32834a3d81"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/hnp.0000000000000061"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jopan.2020.12.005"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1089\/acm.2019.0181"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aev352"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.1136\/acupmed-2013-010340"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa032196"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.1213\/ane.0000000000001617"},{"issue":"4","key":"e_1_2_13_35_1","first-page":"401","article-title":"Evaluation of acupuncture for anti\u2010emetic prophylaxis","volume":"23","author":"Sharma S","year":"2007","journal-title":"J Anaesthesiol Clin Pharmacol"},{"key":"e_1_2_13_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2044.2004.03577.x"},{"key":"e_1_2_13_37_1","doi-asserted-by":"publisher","DOI":"10.1136\/acupmed-2016-011110"},{"key":"e_1_2_13_38_1","doi-asserted-by":"publisher","DOI":"10.1177\/09645284221076517"},{"key":"e_1_2_13_39_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aep014"},{"key":"e_1_2_13_40_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200212000-00009"},{"key":"e_1_2_13_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(09)61706-2"},{"key":"e_1_2_13_42_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.330.7501.1202"},{"key":"e_1_2_13_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00540-017-2363-x"},{"key":"e_1_2_13_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9592.2004.01388.x"},{"key":"e_1_2_13_45_1","doi-asserted-by":"publisher","DOI":"10.4097\/kjae.2016.69.1.1"},{"key":"e_1_2_13_46_1","doi-asserted-by":"publisher","DOI":"10.1093\/bjaceaccp\/mks046"}],"container-title":["United European Gastroenterology Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ueg2.12421","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,18]],"date-time":"2023-08-18T05:23:06Z","timestamp":1692336186000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ueg2.12421"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,15]]},"references-count":45,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2023,7]]}},"alternative-id":["10.1002\/ueg2.12421"],"URL":"https:\/\/doi.org\/10.1002\/ueg2.12421","archive":["Portico"],"relation":{},"ISSN":["2050-6406","2050-6414"],"issn-type":[{"value":"2050-6406","type":"print"},{"value":"2050-6414","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6,15]]}}}