{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T05:12:03Z","timestamp":1788412323796,"version":"build-2803163510"},"reference-count":26,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,6,18]],"date-time":"2023-06-18T00:00:00Z","timestamp":1687046400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004321","name":"Shire","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004321","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007819","name":"Allergan","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007819","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["UEG Journal"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Disorders of Gut\u2010Brain Interaction (DGBI) are highly prevalent worldwide, but their effect on work productivity has not gained much attention.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims and Methods<\/jats:title><jats:p>We aimed to compare work productivity and activity impairment (WPAI) in persons with and without DGBI in a large population\u2010based cohort and identify factors independently associated with WPAI in subjects with DGBI. Data were collected from Germany, Israel, Italy, Japan, the Netherlands, Poland, Spain and Sweden via Internet surveys as part of the Rome Foundation Global Epidemiology Study. Apart from the Rome IV diagnostic questionnaire, questionnaires evaluating WPAI related to general health (WPAI:GH), psychological distress (PHQ\u20104), somatic symptom severity (PHQ\u201015) and other factors were assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 16,820 subjects, 7111 met the criteria for DGBI according to the Rome IV diagnostic questionnaire. Subjects with DGBI were younger (median (interquartile range) age 43 (31\u201358) vs. 47 (33\u201362)) and more often female (59.0% vs. 43.7%) compared to subjects without DGBI. Subjects with DGBI had higher absenteeism, presenteeism (poor work productivity due to illness), overall work impairment and activity impairment (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001) compared with subjects without. For subjects with DGBI affecting more than one anatomical region, WPAI was incrementally higher for each additional region. There were significant differences in WPAI for subjects with DGBI in different countries. Subjects from Sweden had the highest overall work impairment and from Poland the lowest. Using multiple linear regression, male sex, fatigue, psychological distress, somatic symptom severity and number of anatomical regions were independently associated with overall work impairment (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05 for all).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In the general population, people with DGBI have substantial WPAI compared with those without DGBI. The reasons for these findings should be explored further, but having multiple DGBI, psychological distress, fatigue and somatic symptom severity seem to contribute to this impairment associated with DGBI.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ueg2.12425","type":"journal-article","created":{"date-parts":[[2023,6,19]],"date-time":"2023-06-19T04:41:15Z","timestamp":1687149675000},"page":"503-513","source":"Crossref","is-referenced-by-count":29,"title":["Work productivity and activity impairment in disorders of gut\u2010brain interaction: Data from the Rome Foundation Global Epidemiology Study"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6886-7255","authenticated-orcid":false,"given":"\u00c5sa","family":"Fr\u00e4ndemark","sequence":"first","affiliation":[{"name":"Department of Molecular and Clinical Medicine Institute of Medicine Sahlgrenska Academy University of Gothenburg  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2117-9874","authenticated-orcid":false,"given":"Hans","family":"T\u00f6rnblom","sequence":"additional","affiliation":[{"name":"Department of Molecular and Clinical Medicine Institute of Medicine Sahlgrenska Academy University of Gothenburg  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0078-3063","authenticated-orcid":false,"given":"J\u00f3hann P\u00e1ll","family":"Hreinsson","sequence":"additional","affiliation":[{"name":"Department of Molecular and Clinical Medicine Institute of Medicine Sahlgrenska Academy University of Gothenburg  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3695-3327","authenticated-orcid":false,"given":"Viola","family":"Andresen","sequence":"additional","affiliation":[{"name":"Department of Medicine Israelitic Hospital  Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc A.","family":"Benninga","sequence":"additional","affiliation":[{"name":"Emma Children's Hospital Amsterdam UMC University of Amsterdam Pediatric Gastroenterology  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrico S.","family":"Corazziari","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Istituto Clinico Humanitas  Rozzano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shin","family":"Fukudo","sequence":"additional","affiliation":[{"name":"Department of Behavioral Medicine Tohoku University Graduate School of Medicine  Sendai Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4678-8393","authenticated-orcid":false,"given":"Agata","family":"Mulak","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Wroclaw Medical University  Wroclaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Santos","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology University Hospital Vall d\u2019Hebron Autonomous University of Barcelona &amp; 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