{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T02:20:23Z","timestamp":1785550823227,"version":"3.56.0"},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,11,3]],"date-time":"2023-11-03T00:00:00Z","timestamp":1698969600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["UEG Journal"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Several studies have reported large increases in the incidence of eosinophilic oesophagitis (EoE) in the last 20\u00a0years. We aimed to systematically review the incidence and prevalence of EoE, focused on all European countries.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Systematic review and meta\u2010analysis up to 31 December 2022, based on PubMed, CINAHL and extensive hand searching of reference lists. Twenty\u2010five eligible studies were identified and included.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>For both adults and children, the highest EoE incidence and prevalence have been reported from regional studies in Spain. EoE incidence for both adults and children was significantly lower (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001) in nationwide studies (meta\u2010analysis\u00a0=\u00a03.64 per 100,000 person\u2010years overall) compared with regional or centre\u2010based studies (7.16). EoE incidence and prevalence were significantly higher (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001) in adults than children. All studies that reported on longitudinal trends in EoE incidence showed increases over time, more markedly during more recent years. Larger increases in incidence tend to refer to regional rather than nationwide studies; from Spain, Switzerland and Denmark, both for paediatric and adult age groups. Increases in EoE incidence 100,000 person\u2010years were larger than for incidence per number of diagnostic endoscopies. The most frequently reported co\u2010morbidities in adults were rhinitis, followed by asthma, food allergy and gastroesophageal reflux disease, and in children, erosive oesophagitis, asthma, food allergy and rhinitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The incidence of EoE has increased in Europe over the last 30\u00a0years, exceeding increases in the volume of oesophago\u2010gastro\u2010duodenoscopies performed. The patchy and low incidence and prevalence of EoE generally in Europe and compared with North America, may reflect a lack of clinical awareness and research focus rather than a genuinely low incidence of EoE. A co\u2010ordinated Europe\u2010wide study that uses standardised methodology is urgently needed to provide a comprehensive picture of EoE incidence and prevalence across Europe.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ueg2.12465","type":"journal-article","created":{"date-parts":[[2023,11,3]],"date-time":"2023-11-03T15:10:31Z","timestamp":1699024231000},"page":"89-102","source":"Crossref","is-referenced-by-count":34,"title":["Incidence and prevalence of eosinophilic oesophagitis across Europe: A systematic review and meta\u2010analysis"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7981-520X","authenticated-orcid":false,"given":"Stephen E.","family":"Roberts","sequence":"first","affiliation":[{"name":"Swansea University Medical School Swansea University  Swansea 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