{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T00:06:26Z","timestamp":1792022786820,"version":"4.4.0"},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,12,7]],"date-time":"2023-12-07T00:00:00Z","timestamp":1701907200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["UEG Journal"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Earlier studies on the possible association between eosinophilic esophagitis (EoE) and inflammatory bowel disease (IBD) have been contradictory.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Patients with biopsy\u2010verified EoE diagnosed between 1990 and 2017 in Sweden (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a01587) were age\u2010 and sex\u2010matched with up to five general population reference individuals (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a07808). EoE was defined using pathology reports from all 28 pathology centers in Sweden (the ESPRESSO study). Multivariate Cox regression then estimated hazard ratios for future IBD. IBD was defined based on the international classification of disease codes and histopathology codes. In secondary analyses, sibling comparators were used to further reduce potential familial confounding. Additionally, we performed logistic regression examining earlier IBD in EoE.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>During follow\u2010up until 2020, 16 (0.01%) EoE patients and 21 (0.003%) general population reference individuals diagnosed with IBD, corresponding to a 3.5\u2010fold increased risk of future IBD (aHR\u00a0=\u00a03.56; 95% CI 1.79\u20137.11). EoE was linked to Crohn's disease (aHR\u00a0=\u00a03.39 [95% CI 1.02\u20139.60]) but not to ulcerative colitis (aHR\u00a0=\u00a01.37; 95% CI 0.38\u20134.86). Compared to their siblings, patients with EoE were at a 2.48\u2010fold increased risk of IBD (aHR\u00a0=\u00a02.48; 95% CI 0.92\u20136.70). Earlier IBD was 15 times more likely in EoE patients than in matched reference individuals (odds ratio, 15.39; 95% CI 7.68\u201333.59).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In this nationwide cohort study, EoE was associated with a 3.5\u2010fold increased risk of later IBD diagnosis. This risk increase may be due to shared genetic or early environmental risk factors, but also surveillance bias could play a role.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ueg2.12493","type":"journal-article","created":{"date-parts":[[2023,12,7]],"date-time":"2023-12-07T19:05:45Z","timestamp":1701975945000},"page":"34-43","source":"Crossref","is-referenced-by-count":13,"title":["Eosinophilic esophagitis is associated with increased risk of later inflammatory bowel disease in a nationwide Swedish population cohort"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2171-4769","authenticated-orcid":false,"given":"Amiko M.","family":"Uchida","sequence":"first","affiliation":[{"name":"Division of Gastroenterology, Hepatology &amp; Nutrition University of Utah School of Medicine  Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John J.","family":"Garber","sequence":"additional","affiliation":[{"name":"Gastrointestinal Unit Massachusetts General Hospital Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley","family":"Pyne","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology &amp; Nutrition University of Utah School of Medicine  Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn","family":"Peterson","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology &amp; Nutrition University of Utah School of Medicine  Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bjorn","family":"Roelstraete","sequence":"additional","affiliation":[{"name":"Department of Medical Epidemiology and Biostatistics Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ola","family":"Ol\u00e9n","sequence":"additional","affiliation":[{"name":"Clinical Epidemiology Division Department of Medicine Solna Karolinska Institutet  Stockholm Sweden"},{"name":"Sachs' Children and Youth Hospital Stockholm South General Hospital  Stockholm Sweden"},{"name":"Department of Clinical Science and Education S\u00f6dersjukhuset Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0122-7234","authenticated-orcid":false,"given":"Jonas","family":"Halfvarson","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Faculty of Medicine and Health \u00d6rebro University  \u00d6rebro Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonas F.","family":"Ludvigsson","sequence":"additional","affiliation":[{"name":"Department of Medical Epidemiology and Biostatistics Karolinska Institutet  Stockholm Sweden"},{"name":"Department of Pediatrics \u00d6rebro University  \u00d6rebro Sweden"},{"name":"Department of Medicine Celiac Disease Center Columbia University College of Physicians and Surgeons  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,12,7]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2013.09.008"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12305"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/aci.0000000000000196"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2011\u20100204"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2012.06.029"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.iac.2017.09.002"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10388\u2010022\u201000926\u20105"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2018.07.009"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2014.05.036"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.2147\/jaa.s238565"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11894\u2010018\u20100633\u2010x"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/ueg2.12324"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/mpg.0b013e318290d15a"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2018.09.034"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/s2468\u20101253(20)30267\u20103"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1159\/000497236"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl\u20102018\u2010318074"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/mpg.0000000000003002"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2020.02.015"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.48101\/ujms.v127.7687"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654\u2010009\u20109350\u2010y"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654\u2010017\u20100316\u20101"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1177\/140349489001800209"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471\u20102458\u201011\u2010450"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654\u2010016\u20100117\u2010y"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.16735"},{"key":"e_1_2_11_28_1","volume-title":"R: a language and environment for statistical computing","author":"R Core Team","year":"2021"},{"key":"e_1_2_11_29_1","unstructured":"TherneauT._A package for survival analysis in R_. 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