{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T12:59:47Z","timestamp":1788094787735,"version":"build-2803163510"},"reference-count":42,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,11,30]],"date-time":"2023-11-30T00:00:00Z","timestamp":1701302400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["UEG Journal"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background &amp; Aims<\/jats:title><jats:p>Sustained virological response (SVR) by direct\u2010acting antivirals (DAAs) may reverse the hypercoagulable state of HCV cirrhosis and the portal vein thrombosis (PVT) risk. We evaluated the incidence and predictive factors of de novo, non\u2010tumoral PVT in patients with cirrhosis after HCV eradication.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with HCV\u2010related cirrhosis, consecutively enrolled in the multi\u2010center ongoing PITER cohort, who achieved the SVR using DAAs, were prospectively evaluated. Kaplan\u2010Meier and competing risk regression analyses were performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>During a median time of 38.3\u00a0months (IQR: 25.1\u201348.7\u00a0months) after the end of treatment (EOT), among 1609 SVR patients, 32 (2.0%) developed de novo PVT. A\u00a0platelet count \u2264120,000\/\u03bcL, albumin levels \u22643.5\u00a0mg\/dL, bilirubin &gt;1.1\u00a0mg\/dL, a previous liver decompensation, ALBI, Baveno, FIB\u20104, and RESIST scores were significantly different (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001), among patients who developed PVT versus those who did not. Considering death and liver transplantation as competing risk events, esophageal varices (subHR: 10.40; CI 95% 4.33\u201324.99) and pre\u2010treatment ALBI grade \u22652 (subHR: 4.32; CI 95% 1.36\u201313.74) were independent predictors of PVT. After HCV eradication, a significant variation in PLT count, albumin, and bilirubin (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001) versus pre\u2010treatment values was observed in patients who did not develop PVT, whereas no significant differences were observed in those who developed PVT (<jats:italic>p<\/jats:italic>\u00a0&gt;\u00a00.05). After the EOT, esophageal varices and ALBI grade \u22652, remained associated with de novo PVT (subHR: 9.32; CI 95% 3.16\u201327.53 and subHR: 5.50; CI 95% 1.67\u201318.13, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In patients with HCV\u2010related cirrhosis, a more advanced liver disease and significant portal hypertension are independently associated with the de novo PVT risk after SVR.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ueg2.12496","type":"journal-article","created":{"date-parts":[[2023,11,30]],"date-time":"2023-11-30T13:48:13Z","timestamp":1701352093000},"page":"352-363","source":"Crossref","is-referenced-by-count":14,"title":["Predicting <i>de\u2010novo<\/i> portal vein thrombosis after HCV eradication: A long\u2010term competing risk analysis in the ongoing PITER cohort"],"prefix":"10.1002","volume":"12","author":[{"given":"Loreta A.","family":"Kondili","sequence":"first","affiliation":[{"name":"Center for Global Health Istituto Superiore di Sanit\u00e0  Rome Italy"},{"name":"UniCamillus\u2010Saint Camillus International University of Health Sciences  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6734-7178","authenticated-orcid":false,"given":"Alberto","family":"Zanetto","sequence":"additional","affiliation":[{"name":"Gastroenterology and Multivisceral Transplant Unit Azienda Ospedale \u2010 Universit\u00e0 Padova  Padova Italy"},{"name":"Department of Surgery, Oncology and Gastroenterology University of Padova  Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Giovanna","family":"Quaranta","sequence":"additional","affiliation":[{"name":"Center for Global Health Istituto Superiore di Sanit\u00e0  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigina","family":"Ferrigno","sequence":"additional","affiliation":[{"name":"Center for Global Health Istituto Superiore di Sanit\u00e0  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Panetta","sequence":"additional","affiliation":[{"name":"L'altrastatistica srl Consultancy &amp; 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