{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T15:42:54Z","timestamp":1787499774336,"version":"build-2736575974"},"reference-count":26,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,12,7]],"date-time":"2023-12-07T00:00:00Z","timestamp":1701907200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["UEG Journal"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Backgrounds<\/jats:title>\n                    <jats:p>The efficacy of atezolizumab\/bevacizumab has never been reported in patients with metastatic\/unresectable combined hepatocellular\u2010cholangiocarcinoma (cHCC\u2010CCA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>We retrospectively included patients with a histological diagnosis of unresectable\/metastatic cHCC\u2010CCA and treated with atezolizumab\/bevacizumab (2020\u20132022) in 7 centers. Clinical and radiological features were collected at the beginning of atezolizumab\/bevacizumab. We reported the radiological response using RECIST criteria, overall survival (OS) and progression\u2010free survival (PFS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Sixteen patients with cHCC\u2010CCA were included and were predominantly male (75%) with advanced fibrosis\/cirrhosis (69%). Nine patients received atezolizumab\/bevacizumab as a first\u2010line systemic treatment, 5 as a second line, 1 as a third line and 1 as a fifth line. Severe digestive bleeding occurred in 2 patients. Among the 9 patients treated in the first line, 4 experienced radiological progression, 3 partial response and 1 had stable disease. Patients treated with atezolizumab\/bevacizumab in the first line had a median OS of 13\u00a0months and a median PFS of 3\u00a0months. Among the 7 patients receiving atezolizumab\/bevacizumab as a second line or more, 4 patients harbored a stable disease, 2 a partial response, and 1 a progressive disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The combination of atezolizumab and bevacizumab showed signs of anti\u2010tumor efficacy in patients with unresectable\/metastatic cHCC\u2010CCA.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ueg2.12503","type":"journal-article","created":{"date-parts":[[2023,12,7]],"date-time":"2023-12-07T23:21:09Z","timestamp":1701991269000},"page":"429-439","source":"Crossref","is-referenced-by-count":15,"title":["Atezolizumab and bevacizumab for non\u2010resectable or metastatic combined hepatocellular\u2010cholangiocarcinoma: A\u00a0multicentric retrospective study"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5455-2308","authenticated-orcid":false,"given":"Elia","family":"Gigante","sequence":"first","affiliation":[{"name":"Universit\u00e9 de Reims Champagne\u2010Ardenne CHU Reims Service d'H\u00e9pato\u2010Gastroent\u00e9rologie et de Canc\u00e9rologie digestive  Reims France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3919-4135","authenticated-orcid":false,"given":"Mohamed","family":"Bouattour","sequence":"additional","affiliation":[{"name":"Unit\u00e9 Fonctionnelle Oncologie H\u00e9patique H\u00f4pital Beaujon AP\u2010HP  Clichy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0076-2059","authenticated-orcid":false,"given":"Jos\u00e9 Ursic","family":"Bedoya","sequence":"additional","affiliation":[{"name":"Department of Hepatogastroenterology Hepatology and Liver Transplantation Unit Saint Eloi Hospital Institut de G\u00e9n\u00e9tique Mol\u00e9culaire de Montpellier University of Montpellier CNRS  Montpellier France"},{"name":"University of Montpellier  Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9l\u00e8ne","family":"Regnault","sequence":"additional","affiliation":[{"name":"Service d'h\u00e9patologie H\u00f4pital Mondor AP\u2010HP  Cr\u00e9teil France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianne","family":"Ziol","sequence":"additional","affiliation":[{"name":"Service d'Anatomo\u2010Pathologie H\u00f4pital Avicenne AP\u2010HP  Bobigny France"},{"name":"Universit\u00e9 Sorbonne Paris Nord Bobigny&amp; INSERM UMR 1138 Centre de Recherche des Cordeliers Universit\u00e9 de Paris Cit\u00e9  Bobigny France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Assenat","sequence":"additional","affiliation":[{"name":"Department of Hepatogastroenterology Hepatology and Liver Transplantation Unit Saint Eloi Hospital Institut de G\u00e9n\u00e9tique Mol\u00e9culaire de Montpellier University of Montpellier CNRS  Montpellier France"},{"name":"University of Montpellier  Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e9rie","family":"Paradis","sequence":"additional","affiliation":[{"name":"Service d'Anatomo\u2010Pathologie H\u00f4pital Beaujon AP\u2010HP  Clichy France"},{"name":"Centre de recherche sur l'inflammation Inserm Universit\u00e9 de Paris INSERM UMR 1149 \u00ab De l'inflammation au cancer \u00bb  Clichy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julien","family":"Calderaro","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Est Cr\u00e9teil INSERM IMRB  Cr\u00e9teil France"},{"name":"Department of Pathology Assistance Publique\u2010H\u00f4pitaux de Paris Henri Mondor\u2010Albert Chenevier University Hospital  Cr\u00e9teil France"},{"name":"Inserm U955  Cr\u00e9teil France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Ganne\u2010Carri\u00e9","sequence":"additional","affiliation":[{"name":"Service d'h\u00e9patologie H\u00f4pital Avicenne AP\u2010HP  Bobigny France"},{"name":"Universit\u00e9 Sorbonne Paris Nord  Bobigny France"},{"name":"INSERM UMR 1138 Centre de Recherche des Cordeliers Universit\u00e9 de Paris Cit\u00e9  Bobigny France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karine","family":"Bouhier\u2010Leporrier","sequence":"additional","affiliation":[{"name":"Service d'H\u00e9pato\u2010Gastroent\u00e9rologie et de Canc\u00e9rologie digestive CHU Normandie c\u00f4te de Nacre  Caen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuliana","family":"Amaddeo","sequence":"additional","affiliation":[{"name":"Service d'h\u00e9patologie H\u00f4pital Mondor AP\u2010HP  Cr\u00e9teil France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4875-9353","authenticated-orcid":false,"given":"Jean Charles","family":"Nault","sequence":"additional","affiliation":[{"name":"Service d'h\u00e9patologie H\u00f4pital Avicenne AP\u2010HP  Bobigny France"},{"name":"Universit\u00e9 Sorbonne Paris Nord  Bobigny France"},{"name":"INSERM UMR 1138 Centre de Recherche des Cordeliers Universit\u00e9 de Paris Cit\u00e9  Bobigny France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,12,7]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhepr.2020.100174"},{"key":"e_1_2_12_3_1","unstructured":"SempouxC KakarS KondoF SchirmacherP.Combined hepatocellular\u2010cholangiocarcinoma and undifferentiated primary liver carcinoma. 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