{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T20:55:50Z","timestamp":1790110550927,"version":"4.0.1"},"reference-count":34,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,1,29]],"date-time":"2024-01-29T00:00:00Z","timestamp":1706486400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["JR19\/00005"],"award-info":[{"award-number":["JR19\/00005"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["UEG Journal"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Swallowed topical corticosteroids (tC) are common therapy for patients with eosinophilic esophagitis (EoE). Widely heterogeneous results have occurred due to their active ingredients, formulations and doses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess the effectiveness of topical corticosteroid therapy for EoE in real\u2010world practice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Cross\u2010sectional study analysis of the multicentre EoE CONNECT registry. Clinical remission was defined as a decrease of \u226550% in dysphagia symptom scores; histological remission was defined as a peak eosinophil count below 15 per high\u2010power field. The effectiveness in achieving clinico\u2010histological remission (CHR) was compared for the main tC formulations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, data on 1456 prescriptions of tC in monotherapy used in 866 individual patients were assessed. Of those, 904 prescriptions with data on formulation were employed for the induction of remission; 234 reduced a previously effective dose for maintenance. Fluticasone propionate formulations dominated the first\u2010line treatment, while budesonide was more common in later therapies. A swallowed nasal drop suspension was the most common formulation of fluticasone propionate. Doses \u22650.8\u00a0mg\/day provided a 65% CHR rate and were superior to lower doses. Oral viscous solution prepared by a pharmacist was the most common prescription of budesonide; 4\u00a0mg\/day provided no benefit over 2\u00a0mg\/day (CHR rated being 72% and 80%, respectively). A multivariate analysis revealed budesonide orodispersible tablets as the most effective therapy (OR 18.9, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001); use of higher doses (OR 4.3, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.03) and lower symptom scores (OR 0.9, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.01) were also determinants of effectiveness.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Reduced symptom severity, use of high doses, and use of budesonide orodispersible tablets particularly were all independent predictors of tC effectiveness.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ueg2.12533","type":"journal-article","created":{"date-parts":[[2024,1,29]],"date-time":"2024-01-29T14:13:42Z","timestamp":1706537622000},"page":"585-595","source":"Crossref","is-referenced-by-count":28,"title":["Swallowed topical corticosteroids for eosinophilic esophagitis: Utilization and real\u2010world efficacy from the EoE CONNECT registry"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9039-7667","authenticated-orcid":false,"given":"Emilio J.","family":"Laserna\u2010Mendieta","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Hospital General de Tomelloso  Tomelloso Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria La Princesa  Madrid Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria de Castilla\u2010La Mancha (IDISCAM)  Madrid Spain"},{"name":"Laboratory Medicine Department Hospital Universitario de La Princesa  Madrid Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas Instituto de Salud Carlos III  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6293-2570","authenticated-orcid":false,"given":"Pilar","family":"Navarro","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Hospital General de Tomelloso  Tomelloso Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria La Princesa  Madrid Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria de Castilla\u2010La Mancha (IDISCAM)  Madrid Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas Instituto de Salud Carlos III  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6131-8341","authenticated-orcid":false,"given":"Sergio","family":"Casabona\u2010Franc\u00e9s","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n Sanitaria La Princesa  Madrid Spain"},{"name":"Department of Gastroenterology Hospital Universitario de La Princesa  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3187-2894","authenticated-orcid":false,"given":"Edoardo V.","family":"Savarino","sequence":"additional","affiliation":[{"name":"Department of 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