{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T16:02:38Z","timestamp":1791388958299,"version":"4.3.3"},"reference-count":83,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,2,20]],"date-time":"2024-02-20T00:00:00Z","timestamp":1708387200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["UEG Journal"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>It is essential to identify the subgroup of patients who experience poorer outcomes in order to adapt clinical management effectively. In the context of liver disease, the earlier the identification occurs, the greater the range of therapeutic options that can be offered to patients. In the past, patients with acute decompensation (AD) of chronic liver disease were treated as a homogeneous group, with emphasis on identifying those at the highest risk of death. In the last 15\u00a0years, a differentiation has emerged between acute\u2010on\u2010chronic liver failure syndrome (ACLF) and AD, primarily due to indications that the latter is linked to a less favorable short\u2010term prognosis. Nevertheless, the definition of ACLF varies among the different knowledge societies, making it challenging to assess its true impact compared with AD. Therefore, the purpose of this review is to provide a detailed analysis emphasizing the critical importance of identifying ACLF in the field of advanced liver disease. We will discuss the differences between Eastern and Western approaches, particularly in relation to the occurrence of liver failure and disease onset. Common characteristics, such as the dynamic nature of the disease course, will be highlighted. Finally, we will focus on two key clinical implications arising from these considerations: the prevention of ACLF before its onset and the clinical management strategies once it develops, including liver transplantation and withdrawal of care.<\/jats:p>","DOI":"10.1002\/ueg2.12538","type":"journal-article","created":{"date-parts":[[2024,2,20]],"date-time":"2024-02-20T11:51:20Z","timestamp":1708429880000},"page":"194-202","source":"Crossref","is-referenced-by-count":13,"title":["Acute decompensation of cirrhosis versus acute\u2010on\u2010chronic liver failure: What are the clinical implications?"],"prefix":"10.1002","volume":"12","author":[{"given":"Manman","family":"Xu","sequence":"first","affiliation":[{"name":"Fourth Department of Liver Disease (Difficult &amp; Complicated Liver Diseases and Artificial Liver Center) Beijing You'an Hospital Affiliated to Capital Medical University  Beijing China"},{"name":"Beijing Municipal Key Laboratory of Liver Failure and Artificial Liver 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