{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T16:46:50Z","timestamp":1764175610725,"version":"3.40.5"},"reference-count":33,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,2,16]],"date-time":"2024-02-16T00:00:00Z","timestamp":1708041600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["UEG Journal"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Transcutaneous point\u2010shear wave elastography (p\u2010SWE) performed using an acoustic radiation force impulse can be used to quantify pancreatic stiffness in chronic pancreatitis (CP). We aimed to evaluate its usefulness to diagnose and monitor CP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>175 participants were included in this prospective study including patients with CP (<jats:italic>n<\/jats:italic>\u00a0=\u00a065), liver cirrhosis (LC; <jats:italic>n<\/jats:italic>\u00a0=\u00a060), alcohol abuse (<jats:italic>n<\/jats:italic>\u00a0=\u00a010) and healthy controls (<jats:italic>n<\/jats:italic>\u00a0=\u00a040). Point\u2010shear wave elastography of the pancreas was performed and quantified as median shear wave velocity (SWV). In the same way, p\u2010SWE of the spleen served as a marker of portal hypertension. The M\u2010ANNHEIM Severity score was used as global marker for disease activity in CP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared to healthy controls, pancreatic SWV was significantly elevated in CP (1.38 vs. 0.96\u00a0m\/s; <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.0001, MWU\u2010test). Pancreatic SWV was increased in alcoholic CP but not in hereditary CP. Receiver operating characteristic analysis revealed 1.2\u00a0m\/s as the optimal cut\u2010off to identify non\u2010heredity\u2010CP subjects (90% specificity; 81% sensitivity; 92% positive predictive value). Pancreatic SWV correlated significantly with the M\u2010ANNHEIM Severity score, severity of CP\u2010typical complications (both <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05, linear regression analysis), morphological changes of the pancreas and need for hospital treatment (both <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05, MWU\u2010test) but not with exocrine or endocrine insufficiency. Pancreatic SWV &gt;1.7\u00a0m\/s was identified to predict M\u2010ANNHEIM Severity score \u226511 points. Pancreatic SWV was also elevated in LC (1.42\u00a0m\/s; <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001), correlating with increased splenic SWV.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Transcutaneous pancreatic p\u2010SWE represents a bedside, cost\u2010effective and non\u2010invasive tool which adds valuable information to the process of diagnosing and monitoring CP. By portal hypertension, an increased pancreatic SWV must be expected.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ueg2.12543","type":"journal-article","created":{"date-parts":[[2024,2,16]],"date-time":"2024-02-16T14:33:14Z","timestamp":1708093994000},"page":"667-677","source":"Crossref","is-referenced-by-count":3,"title":["Point\u2010shear wave elastography generated by acoustic radiation force impulse in chronic pancreatitis"],"prefix":"10.1002","volume":"12","author":[{"given":"Maximilian","family":"Wekerle","sequence":"first","affiliation":[{"name":"Department of Medicine II Medical Faculty at Mannheim University of Heidelberg  Mannheim Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katharina","family":"Murillo","sequence":"additional","affiliation":[{"name":"Department of Medicine II Medical Faculty at Mannheim University of Heidelberg  Mannheim 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