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To this end, in recent decades, several genetic variants that may help predict and refine the risk of development and progression of MASLD have been investigated. In this review, we aim to discuss the role genetics in MASLD plays in everyday clinical practice. We performed a comprehensive literature search of PubMed for relevant publications. Available evidence highlights the emergence of genetic\u2010based noninvasive algorithms for diagnosing fatty liver, metabolic dysfunction\u2010associated steatohepatitis, fibrosis progression and occurrence of liver\u2010related outcomes including hepatocellular carcinoma. Nevertheless, their accuracy is not optimal and application in everyday clinical practice remains challenging. Furthermore, susceptible genetic markers have recently become subjects of great scientific interest as therapeutic targets in precision medicine. In conclusion, decisional algorithms based on genetic testing in MASLD to facilitate the clinician decisions on management and treatment are under growing investigation and could benefit from artificial intelligence methodology.<\/jats:p>","DOI":"10.1002\/ueg2.12556","type":"journal-article","created":{"date-parts":[[2024,4,25]],"date-time":"2024-04-25T05:45:26Z","timestamp":1714023926000},"page":"638-648","source":"Crossref","is-referenced-by-count":4,"title":["Are we ready for genetic testing in metabolic dysfunction\u2010associated steatotic liver disease?"],"prefix":"10.1002","volume":"12","author":[{"given":"Adele","family":"Tulone","sequence":"first","affiliation":[{"name":"Sezione di Gastroenterologia PROMISE University of Palermo  Palermo Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grazia","family":"Pennisi","sequence":"additional","affiliation":[{"name":"Sezione di Gastroenterologia PROMISE University of Palermo  Palermo 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