{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,27]],"date-time":"2025-12-27T10:06:27Z","timestamp":1766829987788,"version":"3.40.5"},"reference-count":24,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,4,6]],"date-time":"2024-04-06T00:00:00Z","timestamp":1712361600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["UEG Journal"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Biliary tract cancer (BTC) often goes undetected until its advanced stages, resulting in a poor prognosis. Given the anatomical closeness of the gallbladder and bile ducts to the pancreas, the inflammatory processes triggered by acute pancreatitis might increase the risk of BTC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess the association between acute pancreatitis and the risk of BTC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Using the Swedish Pancreatitis Cohort (SwePan), we compared the BTC risk in patients with a first\u2010time episode of acute pancreatitis during 1990\u20132018 to a 1:10 matched pancreatitis\u2010free control group. Multivariable Cox regression models, stratified by follow\u2010up duration, were used to calculate hazard ratios (HRs), adjusting for socioeconomic factors, alcohol use, and comorbidities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>BTC developed in 0.94% of 85,027 acute pancreatitis patients and in 0.23% of 814,993 controls. The BTC risk notably increased within 3\u00a0months of hospital discharge (HR 82.63; 95% CI: 63.07\u2013108.26) and remained elevated beyond 10\u00a0years of follow\u2010up (HR 1.82; 95% CI: 1.35\u20132.47). However, the long\u2010term risk of BTC subtypes did not increase with anatomical proximity to the pancreas, with a null association for gallbladder and extrahepatic tumors. Importantly, patients with acute pancreatitis had a higher occurrence of early\u2010stage BTC within 2\u00a0years of hospital discharge than controls (13.0 vs. 3.6%; <jats:italic>p<\/jats:italic>\u2010value &lt;0.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our nationwide study found an elevated BTC risk in acute pancreatitis patients; however, the risk estimates for BTC subtypes were inconsistent, thereby questioning the causality of the association. Importantly, the amplified detection of early\u2010stage BTC within 2\u00a0years after a diagnosis of acute pancreatitis underscores the necessity for proactive BTC surveillance in these patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ueg2.12567","type":"journal-article","created":{"date-parts":[[2024,4,6]],"date-time":"2024-04-06T15:10:10Z","timestamp":1712416210000},"page":"726-736","source":"Crossref","is-referenced-by-count":1,"title":["Exploring the association between acute pancreatitis and biliary tract cancer: A large\u2010scale population\u2010based matched cohort study"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9969-1643","authenticated-orcid":false,"given":"Daniel","family":"Selin","sequence":"first","affiliation":[{"name":"Department of Clinical Science, Intervention and Technology Karolinska Institutet  Stockholm Sweden"},{"name":"Centre for Clinical Research S\u00f6rmland Uppsala University  Eskilstuna 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