{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,30]],"date-time":"2025-11-30T16:03:01Z","timestamp":1764518581403,"version":"3.46.0"},"reference-count":18,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,5,8]],"date-time":"2024-05-08T00:00:00Z","timestamp":1715126400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["FI20\/00033","INT20\/00061","PI19\/01360"],"award-info":[{"award-number":["FI20\/00033","INT20\/00061","PI19\/01360"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015755","name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100015755","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017784","name":"Gilead Research Scholars","doi-asserted-by":"publisher","award":["GLD18\u2010192"],"award-info":[{"award-number":["GLD18\u2010192"]}],"id":[{"id":"10.13039\/100017784","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["UEG Journal"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background &amp; Aims<\/jats:title>\n                    <jats:p>Several hepatocellular carcinoma (HCC) risk\u2010models have been developed to individualise patient surveillance following sustained viral response (SVR) in Hepatitis C Virus patients. Validation of these models in different cohorts is an important step to incorporate a more personalised risk assessment in clinical practice. We aimed at applying these models to stratify the risk in our patients and potentially determine cost\u2010saving associated with individualised HCC risk\u2010stratification screening strategy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients with baseline F3\u20104 fibrosis treated with new oral direct\u2010acting antivirals who had reached a SVR were regularly followed as part of the HCC surveillance strategy. Six models were applied: Pons, aMAP, Ioannou, HCC risk, Alonso and Semmler. Validation of the models was performed based on sensitivity and the proportion of patients labelled as \u201chigh risk\u201d.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>After excluding 557 with less than 3 fibrosis, 12 without SVR, 18 with a follow up (FU)\u00a0&lt;1\u00a0year, 17 transplant recipients, 16 lost to FU and 31 with HCC at time of antiviral therapy, our cohort consisted of 349 F3\u20104 SVR patients. Twenty\u2010three patients (6.6%) developed HCC after a median FU of 5.12\u00a0years. The sensitivity of the different models varied between 0.17 (Semmler7noalcohol) and 1 (Alonso A and aMAP). The lowest proportion of high\u2010risk patients corresponded to the Semmler\u2010noalcohol model (5%). Sixty\u2010three and 90% of the Alonso A and aMAP patients, respectively were labelled as high risk. The most reliable HCC risk\u2010model applied to our cohort to predict HCC development is the Alonso model (based on fibrosis stage assessed by liver stiffness measurements or Fibrosis\u20104 index (FIB\u20104) at baseline and after 1\u00a0year, and albumin levels at 1\u00a0year) with a\u2010100% sensitivity in detecting HCC among those at high risk and 63% labelled as high risk. The application of the model would have saved the cost of 1290 ultrasound no longer being performed in the 37% low\u2010risk group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In our cohort, the Alonso A model allows the most reliable reduction in HCC screening resulting in safely stopping life\u2010long monitoring in about a third of F3\u2010F4 patients achieving SVR with DAAs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ueg2.12571","type":"journal-article","created":{"date-parts":[[2024,5,9]],"date-time":"2024-05-09T01:24:46Z","timestamp":1715217886000},"page":"901-910","source":"Crossref","is-referenced-by-count":0,"title":["External validation of models to predict hepatocellular carcinoma in Hepatitis C Virus cured F3\u2010F4 patients"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5424-3479","authenticated-orcid":false,"given":"\u00c2ngela","family":"Carvalho\u2010Gomes","sequence":"first","affiliation":[{"name":"Hepatology, Hepatobiliopancreatic Surgery and Transplant Group La Fe Health Research Institute (IIS La Fe)  Valencia Spain"},{"name":"National Institute for the Study of Liver and Gastrointestinal Diseases CIBEREHD Instituto de Salud Carlos III (ISCIII)  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsveta Vladi","family":"Valcheva Valcheva","sequence":"additional","affiliation":[{"name":"Hepatology, Hepatobiliopancreatic Surgery and Transplant Group La Fe Health Research Institute (IIS La Fe)  Valencia Spain"},{"name":"Medicine Department University of Valencia  Valencia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iv\u00e1n","family":"Sahuco","sequence":"additional","affiliation":[{"name":"Hepatology, Hepatobiliopancreatic Surgery and Transplant Group La Fe Health Research Institute (IIS La Fe)  Valencia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enrique","family":"Vidal","sequence":"additional","affiliation":[{"name":"Laboratory of Cellular and Molecular Biology Health Research Institute Hospital La Fe  Valencia Spain"},{"name":"Clinical and Translational Research in Cancer Health Research Institute Hospital La Fe  Valencia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0683-8651","authenticated-orcid":false,"given":"Laura","family":"Mart\u00ednez\u2010Arenas","sequence":"additional","affiliation":[{"name":"Hepatology, Hepatobiliopancreatic Surgery and Transplant Group La Fe Health Research Institute (IIS La Fe)  Valencia Spain"},{"name":"National Institute for the Study of Liver and Gastrointestinal Diseases CIBEREHD Instituto de Salud Carlos III (ISCIII)  Madrid Spain"},{"name":"Department of Biotechnology Universitat Polit\u00e8cnica de Val\u00e8ncia  Valencia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmen","family":"Vinaixa","sequence":"additional","affiliation":[{"name":"Hepatology, Hepatobiliopancreatic Surgery and Transplant Group La Fe Health Research Institute (IIS La Fe)  Valencia Spain"},{"name":"National Institute for the Study of Liver and Gastrointestinal Diseases CIBEREHD Instituto de Salud Carlos III (ISCIII)  Madrid Spain"},{"name":"Department of Gastroenterology Hepatology Unit La Fe University Hospital  Valencia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victoria","family":"Aguilera","sequence":"additional","affiliation":[{"name":"Hepatology, Hepatobiliopancreatic Surgery and Transplant Group La Fe Health Research Institute (IIS La Fe)  Valencia Spain"},{"name":"National Institute for the Study of Liver and Gastrointestinal Diseases CIBEREHD Instituto de Salud Carlos III (ISCIII)  Madrid Spain"},{"name":"Department of Gastroenterology Hepatology Unit La Fe University Hospital  Valencia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u00f3nia","family":"Garc\u00eda Garc\u00eda","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Hepatology Unit La Fe University Hospital  Valencia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9246-4264","authenticated-orcid":false,"given":"Marina","family":"Berenguer","sequence":"additional","affiliation":[{"name":"Hepatology, Hepatobiliopancreatic Surgery and Transplant Group La Fe Health Research Institute (IIS La Fe)  Valencia Spain"},{"name":"National Institute for the Study of Liver and Gastrointestinal Diseases CIBEREHD Instituto de Salud Carlos III (ISCIII)  Madrid Spain"},{"name":"Medicine Department University of Valencia  Valencia Spain"},{"name":"Department of Gastroenterology Hepatology Unit La Fe University Hospital  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