{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T16:04:28Z","timestamp":1779293068821,"version":"3.51.4"},"reference-count":31,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,6,20]],"date-time":"2024-06-20T00:00:00Z","timestamp":1718841600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["UEG Journal"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The Japan Esophageal Society proposed the JES microvessel classification to assess eligibility of early esophageal squamous cell neoplasia (ESCN) for endoscopic resection based on intrapapillary capillary loop assessment. We aimed to assess its diagnostic reproducibility and accuracy in Western ESCN patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Intrapapillary capillary loops on endoscopic images of Western ESCN lesions (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0113) collected between 2010 and 2022 were assessed by nine endoscopists, including three Japanese expert endoscopists, three Western expert endoscopists, and three residents\u2010in\u2010training, and graded according to the JES microvessel classification where microvessel type A corresponds with normality or low\u2010grade intraepithelial neoplasia, and microvessel types B1, B2, and B3 correspond with high\u2010grade intraepithelial neoplasia or invasion into the lamina propria, muscularis mucosae or superficial submucosa, and deep submucosa, respectively. Outcomes included overall accuracy in predicting ESCN invasion depth and interobserver agreement.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Good interobserver agreement was observed among expert endoscopists (Krippendorf's alpha 0.64, 95% CI 0.57\u20130.70), while agreement was moderate among residents\u2010in\u2010training (Krippendorf's alpha 0.58, 95% CI 0.52\u20130.72). Overall accuracy of the JES microvessel classification was 53% (95% CI 42\u201363), 52% (95% CI 41\u201362), and 44% (95% CI 34\u201355) for Japanese endoscopists, Western endoscopists, and residents\u2010in\u2010training, respectively. Sensitivity and specificity for vessel type A, B1, B2, and B3 across assessors were 0%\u201350% and 89%\u2013100%, 55%\u201364% and 66%\u201377%, 42%\u201371% and 60%\u201376%, and 10%\u201324% and 92%\u201397%, respectively. Negative predictive value ranged between 80% and 85% for B3 vessels.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Overall accuracy of the JES microvessel classification in Western ESCN patients is low, though absence of B3 vessels as assessed by experienced endoscopists may predict superficial ESCN amenable to endoscopic resection.<\/jats:p>\n                    <jats:p>\n                      <jats:bold>Trial registry:<\/jats:bold>\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.trialregister.nl\">www.trialregister.nl<\/jats:ext-link>\n                      ; NL8897 (6\u20109\u20102020)\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ueg2.12601","type":"journal-article","created":{"date-parts":[[2024,6,21]],"date-time":"2024-06-21T02:43:42Z","timestamp":1718937822000},"page":"1069-1080","source":"Crossref","is-referenced-by-count":3,"title":["The Japanese Esophageal Society classification for prediction of superficial esophageal squamous cell neoplasia invasion depth: Validation in a Western population"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5334-6609","authenticated-orcid":false,"given":"I. (Ilse) N.","family":"Beaufort","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology St. Antonius Hospital  Nieuwegein The Netherlands"},{"name":"Department of Gastroenterology and Hepatology University Medical Center Utrecht  Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N. (Nicolaas) A. P.","family":"Zuithoff","sequence":"additional","affiliation":[{"name":"Julius Center for Health Sciences and Primary Care University Medical Center Utrecht  Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. (Lodewijk) A. A.","family":"Brosens","sequence":"additional","affiliation":[{"name":"Department of Pathology University Medical Center Utrecht Utrecht University  Utrecht the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. (Kazuhiro)","family":"Furukawa","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Nagoya University Graduate School of Medicine  Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O. (Osamu)","family":"Goto","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Nippon Medical School, Graduate School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. (Arjun) D.","family":"Koch","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Erasmus MC Cancer Institute University Medical Center  Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. (Maartje) van de","family":"Meeberg","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology University Medical Center Utrecht  Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6164-1536","authenticated-orcid":false,"given":"W. (Wouter) B.","family":"Nagengast","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology University of Groningen University Medical Center Groningen  Groningen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4707-1186","authenticated-orcid":false,"given":"R. (Roos) E.","family":"Pouw","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Amsterdam University Medical Center location VUmc Cancer Center Amsterdam  Amsterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. (Kuna)","family":"Rueb","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology University Medical Center Utrecht  Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. (Caroline)","family":"Saleh","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Erasmus MC Cancer Institute University Medical Center  Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. (Erik) J.","family":"Schoon","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Catharina Hospital  Eindhoven The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. (Stefan)","family":"Seewald","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Klinik Hirslanden  Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. (Shunsuke)","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology National Hospital Organization Osaka National Hospital  Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. (Marnix)","family":"Jansen","sequence":"additional","affiliation":[{"name":"Department of Pathology University College London and UCL Cancer Institute  London England"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B. (Bas) L. A. 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