{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T06:43:17Z","timestamp":1787726597302,"version":"build-2784847793"},"reference-count":34,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002850","name":"Fondo Nacional de Desarrollo Cient\u00edfico y Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["1230504"],"award-info":[{"award-number":["1230504"]}],"id":[{"id":"10.13039\/501100002850","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["UEG Journal"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Gastric cancer (GC) is one of the most lethal malignancies worldwide. <jats:italic>Helicobacter pylori<\/jats:italic> is the primary cause of GC; therefore, its eradication reduces the risk of developing this neoplasia. There is extensive evidence regarding quadruple therapy with relevance to the European population. However, in Latin America, data are scarce. Furthermore, there is limited information about the eradication rates achieved by antibiotic schemes in European and Latin American populations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To compare the effectiveness of standard triple therapy (STT), quadruple concomitant therapy (QCT), and bismuth quadruple therapy (QBT) in six centers in Europe and Latin America.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective study was carried out based on the LEGACy registry from 2017 to 2022. Data from adult patients recruited in Portugal, Spain, Chile, Mexico, and Paraguay with confirmed <jats:italic>H<\/jats:italic>. <jats:italic>pylori<\/jats:italic> infection who received eradication therapy and confirmatory tests at least 1\u00a0month apart were included. Treatment success by each scheme was compared using a mixed multilevel Poisson regression, adjusting for patient sex and age, together with country\u2010specific variables, including prevalence of <jats:italic>H<\/jats:italic>. <jats:italic>pylori<\/jats:italic> antibiotic resistance (clarithromycin, metronidazole, and amoxicillin), and <jats:italic>CYP2C19<\/jats:italic> polymorphisms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>772 patients were incorporated (64.64% females; mean age of 52.93\u00a0years). The total <jats:italic>H<\/jats:italic>. <jats:italic>pylori<\/jats:italic> eradication rates were 75.20% (255\/339) with STT, 88.70% (159\/178) with QCT, and 91.30% (191\/209) with QBT. Both quadruple therapies (QCT\u2010QBT) showed significantly higher eradication rates compared with STT, with an adjusted incidence risk ratio (IRR) of 1.25 (<jats:italic>p<\/jats:italic>: &lt;0.05); and 1.24 (<jats:italic>p<\/jats:italic>: &lt;0.05), respectively. The antibiotic\u2010resistance prevalence by country, but not the prevalence of <jats:italic>CYP2C19<\/jats:italic> polymorphism, showed a statistically significant impact on eradication success.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Both QCT and QBT are superior to STT for <jats:italic>H<\/jats:italic>. <jats:italic>pylori<\/jats:italic> eradication when adjusted for country\u2010specific antibiotic resistance and <jats:italic>CYP2C19<\/jats:italic> polymorphism in a sample of individuals residing in five countries within two continents.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ueg2.12605","type":"journal-article","created":{"date-parts":[[2024,8,2]],"date-time":"2024-08-02T04:39:34Z","timestamp":1722573574000},"page":"1190-1199","source":"Crossref","is-referenced-by-count":11,"title":["Quadruple therapies show a higher eradication rate compared to standard triple therapy for <i>Helicobacter pylori<\/i> infection within the LEGACy consortium. A multicenter observational study in European and Latin American countries"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3784-1463","authenticated-orcid":false,"given":"Patricio","family":"Medel\u2010Jara","sequence":"first","affiliation":[{"name":"Facultad de Medicina Programa de Doctorado en Epidemiolog\u00eda Pontificia Universidad Cat\u00f3lica de Chile  Santiago Chile"},{"name":"Facultad de Medicina Programa de Farmacolog\u00eda y Toxicolog\u00eda Pontificia Universidad Cat\u00f3lica de Chile  Santiago Chile"},{"name":"Facultad de Medicina Carrera de Terapia Ocupacional Pontificia Universidad Cat\u00f3lica de Chile  Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6371-3516","authenticated-orcid":false,"given":"Diego","family":"Reyes Placencia","sequence":"additional","affiliation":[{"name":"Departamento de Gastroenterolog\u00eda Escuela de Medicina Pontificia Universidad Cat\u00f3lica de Chile  Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Fuentes\u2010L\u00f3pez","sequence":"additional","affiliation":[{"name":"Facultad de Medicina Departamento de Ciencias de la Salud Pontificia Universidad Cat\u00f3lica de Chile  Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oscar","family":"Corsi","sequence":"additional","affiliation":[{"name":"Departamento de Gastroenterolog\u00eda Escuela de Medicina Pontificia Universidad Cat\u00f3lica de Chile  Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gonzalo","family":"Latorre","sequence":"additional","affiliation":[{"name":"Departamento de Gastroenterolog\u00eda Escuela de Medicina Pontificia Universidad Cat\u00f3lica de Chile  Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosario","family":"Ant\u00f3n","sequence":"additional","affiliation":[{"name":"Digestive Medicine Department Hospital Cl\u00ednico Universitario de Valencia  Valencia Spain"},{"name":"Biochemistry Department and Molecular Biology Universidad de Valencia  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Jim\u00e9nez","sequence":"additional","affiliation":[{"name":"INCLIVA Biomedical Research Institute  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Miralles\u2010Marco","sequence":"additional","affiliation":[{"name":"INCLIVA Biomedical Research Institute  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmelo","family":"Caballero","sequence":"additional","affiliation":[{"name":"GenPat Laboratory  Asunci\u00f3n Paraguay"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugo","family":"Boggino","sequence":"additional","affiliation":[{"name":"GenPat Laboratory  Asunci\u00f3n Paraguay"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Cantero","sequence":"additional","affiliation":[{"name":"Endoscopy Department Instituto de Previsi\u00f3n Social  Asunci\u00f3n Paraguay"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita","family":"Barros","sequence":"additional","affiliation":[{"name":"IPATIMUP \u2010 Institute of Pathology and Molecular Immunology of the University of Porto  Porto Portugal"},{"name":"Department of Pathology Medical Faculty of the University of Porto  Porto Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0614-0576","authenticated-orcid":false,"given":"Jo\u00e3o","family":"Santos\u2010Antunes","sequence":"additional","affiliation":[{"name":"IPATIMUP \u2010 Institute of Pathology and Molecular Immunology of the University of Porto  Porto Portugal"},{"name":"Department of Gastroenterology Centro Hospitalar Universit\u00e1rio de S. 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