{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T16:39:05Z","timestamp":1781627945919,"version":"3.54.5"},"reference-count":33,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,8,6]],"date-time":"2024-08-06T00:00:00Z","timestamp":1722902400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["UEG Journal"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Gelsectan\n                      <jats:sup>\u00ae<\/jats:sup>\n                      is a formulation of xyloglucan (XG), pea protein, grape seed extract (PPGS) and xylo\u2010oligosaccharides (XOS). Our aim was to examine the effect of Gelsectan\n                      <jats:sup>\u00ae<\/jats:sup>\n                      on rectal sensitivity in an animal model, abdominal pain in irritable bowel syndrome with diarrhoea (IBS\u2010D) subjects and intestinal permeability in both conditions.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Animals: Wistar rats received gavage with XOS, XG\u00a0+\u00a0PPGS or XG\u00a0+\u00a0PPGS\u00a0+\u00a0XOS, as a single dose or for 7\u00a0days before a partial restraint stress (PRS). Visceromotor response to rectal distension and total gut paracellular permeability to\n                      <jats:sup>51<\/jats:sup>\n                      Cr\u2010EDTA were assessed. Humans: IBS\u2010D and control patients were involved. After initial colonoscopy with biopsy sampling Gelsectan\u00ae was administered to IBS\u2010D patients for 12\u00a0weeks. Stool count and pain scores were documented. After treatment, colonoscopy was repeated. The permeability of biopsy samples was measured in Ussing\u2010chambers. Adherent mucus layer, Muc\u20102 expression as well as TNF\u03b1, Interferon IFN\u03b3 were evaluated by histology\/immunohistochemistry and ELISA assays, respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Animal studies: In control rats, PRS significantly increased visceromotor response as well as gut paracellular permeability. Single dose administration of XG\u00a0+\u00a0PPGS\u00a0+\u00a0XOS failed to reverse PRS, but 7\u00a0days of oral treatment reversed PRS\u2010induced rectal hypersensitivity and gut hyperpermeability. Human studies: Gelsectan\n                      <jats:sup>\u00ae<\/jats:sup>\n                      treatment significantly reduced and abdominal pain. Intestinal permeability in IBS\u2010D patients was elevated compared with controls, Gelsectan\n                      <jats:sup>\u00ae<\/jats:sup>\n                      restored permeability in the ascendent colon. Periodic acid\u2013Schiff\u2010stained mucus layer was significantly thinner in IBS\u2010D patients compared with controls, In both segments, mucus thickness and the proportion of Muc\u20102 positive cells were not affected by Gelsectan\n                      <jats:sup>\u00ae<\/jats:sup>\n                      treatment. IFN\u03b3 tissue level in the sigmoid colon shows modest mucosal inflammation in IBS\u2010D.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Gelsectan\n                      <jats:sup>\u00ae<\/jats:sup>\n                      prevented rectal hypersensitivity in rats, abdominal pain in human and intestinal hyperpermeability in rat and human studies respectively. These effects involve restoration of gut permeability. Based on this translational study, Gelsectan\n                      <jats:sup>\u00ae<\/jats:sup>\n                      can be considered as an effective therapy for IBS\u2010D symptoms.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ueg2.12625","type":"journal-article","created":{"date-parts":[[2024,8,6]],"date-time":"2024-08-06T12:32:56Z","timestamp":1722947576000},"page":"1102-1113","source":"Crossref","is-referenced-by-count":6,"title":["Translational evaluation of Gelsectan\n                    <sup>\u00ae<\/sup>\n                    effects on gut barrier dysfunction and visceral pain in animal models and irritable bowel syndrome with diarrhoea"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7974-1263","authenticated-orcid":false,"given":"Orsolya","family":"Inczefi","sequence":"first","affiliation":[{"name":"Department of Medicine Centre for Gastroenterology University of Szeged  Szeged Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9l\u00e8ne","family":"Eutamene","sequence":"additional","affiliation":[{"name":"UMR 1331 Toxalim (Research Centre in Food Toxicology) INRAE Universit\u00e9 de Toulouse III ENVT  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fanny","family":"Placide","sequence":"additional","affiliation":[{"name":"UMR 1331 Toxalim (Research Centre in Food Toxicology) INRAE Universit\u00e9 de Toulouse III ENVT  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e9rie","family":"Tondereau","sequence":"additional","affiliation":[{"name":"UMR 1331 Toxalim (Research Centre in Food Toxicology) INRAE Universit\u00e9 de Toulouse III ENVT  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petra","family":"Pallagi","sequence":"additional","affiliation":[{"name":"Department of Medicine Centre for Gastroenterology University of Szeged  Szeged Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e1ria","family":"Bagy\u00e1nszki","sequence":"additional","affiliation":[{"name":"Department of Physiology Anatomy and Neuroscience Faculty of Science and Informatics University of Szeged  Szeged Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolett","family":"B\u00f3di","sequence":"additional","affiliation":[{"name":"Department of Physiology Anatomy and Neuroscience Faculty of Science and Informatics University of Szeged  Szeged Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolett","family":"G\u00e9mes","sequence":"additional","affiliation":[{"name":"Laboratory of Functional Genomics HUN\u2010REN Biological Research Centre  Szeged Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00e1bor","family":"Szebeni","sequence":"additional","affiliation":[{"name":"Laboratory of Functional Genomics HUN\u2010REN Biological Research Centre  Szeged Hungary"},{"name":"Department of Internal Medicine Hematology Centre Faculty of Medicine University of Szeged  Szeged Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0599-182X","authenticated-orcid":false,"given":"Tam\u00e1s","family":"Moln\u00e1r","sequence":"additional","affiliation":[{"name":"Department of Medicine Centre for Gastroenterology University of Szeged  Szeged Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vassilia","family":"Theodorou","sequence":"additional","affiliation":[{"name":"UMR 1331 Toxalim (Research Centre in Food Toxicology) INRAE Universit\u00e9 de Toulouse III ENVT  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rich\u00e1rd","family":"R\u00f3ka","sequence":"additional","affiliation":[{"name":"Department of Medicine Centre for Gastroenterology University of Szeged  Szeged Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,8,6]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/hsr2.1592"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.0954"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.2174\/1573397112666151231110521"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i22.6759"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i39.14105"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00155.2012"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2011.83"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016\u20105085(88)90231\u20104"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2004.10.002"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/17562848211020570"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/2050640619862721"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.2147\/ppa.s318859"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/gidisord4040030"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/fsn3.3688"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13068\u2010019\u20101527\u20103"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1039\/c3fo60348b"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.5435\/jaaosglobal\u2010d\u201017\u201000088"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2006.115352"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl\u20102012\u2010303207"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1243233"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365\u20102982.2002.00305.x"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781119127437.ch26"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1177\/1756284821993586"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1203\/pdr.0b013e3180db2949"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2006.050958"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743\u20103150.2004.00490.x"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535\u2010021\u201001838\u20104"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/1827937"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12876\u2010021\u201001722\u20108"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.47.4.589"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1306070110"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00290.2013"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1080\/17474124.2018.1378573"}],"container-title":["United European Gastroenterology Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ueg2.12625","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,30]],"date-time":"2025-11-30T16:06:02Z","timestamp":1764518762000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ueg2.12625"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,6]]},"references-count":33,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["10.1002\/ueg2.12625"],"URL":"https:\/\/doi.org\/10.1002\/ueg2.12625","archive":["Portico"],"relation":{},"ISSN":["2050-6406","2050-6414"],"issn-type":[{"value":"2050-6406","type":"print"},{"value":"2050-6414","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,6]]}}}