{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T15:59:56Z","timestamp":1793289596860,"version":"4.5.0"},"reference-count":46,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,7,15]],"date-time":"2024-07-15T00:00:00Z","timestamp":1721001600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["UEG Journal"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Our purpose was to assess the impact of muscle quality on overall survival (OS) in patients with advanced HCC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This is a subanalysis of the SORAMIC trial. Overall, 363 patients were included. The SIRT\/Sorafenib treatment group comprised 182 patients and the sorafenib group 181 patients. Myosteatosis was defined as skeletal muscle density (SMD)\u00a0&lt;\u00a041 HU for patients with a body mass index up to 24.9\u00a0kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      and &lt;33 HU for patients with a body mass index \u226525\u00a0kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      . Albumin\u2010gauge score was calculated as follows: serum albumin (g\/dL) \u00d7 SMD (HU). To assess the impact of muscle quality on clinical variables and OS, a Cox regression model was used. Hazard ratios are presented together with 95 % confidence intervals (95 % CI). Kaplan\u2010Meier curves were used for survival analysis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In the SIRT\/sorafenib cohort, low albumin\u2010gauge score was an independent predictor of worse OS, HR\u00a0=\u00a01.74, CI 95% (1.16\u20132.62),\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.01. In the sorafenib cohort, muscle quality parameters did not predict OS. In alcohol\u2010induced HCC (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0129), myosteatosis independently predicted OS, HR\u00a0=\u00a01.85, CI 95% (1.10; 3.12),\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.02. In viral\u2010induced HCC (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a099), parameters of muscle quality did not predict OS. In patients with NASH\/Non\u2010alcoholic fatty liver disease (NAFLD) induced HCC, albumin\u2010gauge score was a strong independent predictor of worse OS in the subgroup undergoing combined treatment with SIRT and sorafenib, HR\u00a0=\u00a09.86, CI 95% (1.12; 86.5),\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.04.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Myosteatosis predicts independently worse OS in patients with alcohol\u2010induced HCC undergoing combined treatment with SIRT and sorafenib. In patients with NASH\/NAFLD induced HCC undergoing treatment with SIRT and sorafenib, albumin\u2010gauge score predicts independently worse OS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Impact and implications<\/jats:title>\n                    <jats:p>Associations between parameters of muscle quality and OS are different in accordance to the treatment strategy and etiology of HCC. These findings highlight the prognostic potential of skeletal muscle quality in patients with advanced HCC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ueg2.12627","type":"journal-article","created":{"date-parts":[[2024,7,15]],"date-time":"2024-07-15T10:40:32Z","timestamp":1721040032000},"page":"1016-1027","source":"Crossref","is-referenced-by-count":12,"title":["Skeletal muscle quality predicts overall survival in advanced liver hepatocellular carcinoma treated with SIRT and sorafenib: A subanalysis of the SORAMIC trial"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9273-3943","authenticated-orcid":false,"given":"Alexey","family":"Surov","sequence":"first","affiliation":[{"name":"Department of Radiology Neuroradiology and Nuclear Medicine Johannes Wesling University Hospital Ruhr University Bochum  Bochum Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Wienke","sequence":"additional","affiliation":[{"name":"Institute of Medical Epidemiology Biometry and Informatics University of Halle  Halle Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Borggrefe","sequence":"additional","affiliation":[{"name":"Department of Radiology Neuroradiology and Nuclear Medicine Johannes Wesling University Hospital Ruhr University Bochum  Bochum Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mattes","family":"Hinnerichs","sequence":"additional","affiliation":[{"name":"University Clinic for Radiology and Nuclear Medicine University Hospital Magdeburg  Magdeburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricarda","family":"Seidensticker","sequence":"additional","affiliation":[{"name":"Department of Radiology University Hospital LMU Munich  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osman","family":"\u00d6cal","sequence":"additional","affiliation":[{"name":"Department of Radiology University Hospital LMU Munich  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerstin","family":"Sch\u00fctte","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Gastroenterology Niels\u2010Stensen\u2010Kliniken Marienhospital  Osnabr\u00fcck Germany"},{"name":"Klinik f\u00fcr Gastroenterologie Hepatologie und Endokrinologie Medizinische Hochschule Hannover (MHH)  Hannover Deutschland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4707-4563","authenticated-orcid":false,"given":"Christoph J.","family":"Zech","sequence":"additional","affiliation":[{"name":"Radiology and Nuclear Medicine University Hospital Basel University of Basel  Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Loewe","sequence":"additional","affiliation":[{"name":"Section of Cardiovascular and Interventional Radiology Department of Bioimaging and Image\u2010Guided Therapy Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Otto","family":"van Delden","sequence":"additional","affiliation":[{"name":"Department of Radiology and Nuclear Medicine Academic University Medical Centers  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Vandecaveye","sequence":"additional","affiliation":[{"name":"Department of Radiology University Hospitals Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris","family":"Verslype","sequence":"additional","affiliation":[{"name":"Department of Digestive Oncology University Hospitals Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernhard","family":"Gebauer","sequence":"additional","affiliation":[{"name":"Department of Radiology Charit\u00e9 \u2013 University Medicine Berlin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Sengel","sequence":"additional","affiliation":[{"name":"Radiology Department Grenoble University Hospital  La Tronche France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Bargellini","sequence":"additional","affiliation":[{"name":"Department of Vascular and Interventional Radiology University Hospital of Pisa  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Iezzi","sequence":"additional","affiliation":[{"name":"Dipartimento di Diagnostica per Immagini Fondazione Policlinico Universitario A. 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