{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T10:45:12Z","timestamp":1789382712903,"version":"build-2803163510"},"reference-count":40,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,7,29]],"date-time":"2024-07-29T00:00:00Z","timestamp":1722211200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["UEG Journal"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Stricturing, penetrating complications and extraintestinal manifestations (EIMs) are frequent in patients with inflammatory bowel disease (IBD). There is limited data on the prevalence of these complications in patients with IBD. Therefore, we aimed to assess the burden of these complications detected incidentally on cross\u2010sectional imaging.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective study conducted at two tertiary care centers in London, Ontario. Patients (\u226518\u00a0years) with a confirmed diagnosis of IBD who underwent CT enterography (CTE) or MR enterography (MRE) between 1 Jan 2010 and 31 Dec 2018 were included. Categorical variables were reported as proportions and the mean and standard deviations were reported for continuous variables.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 615 imaging tests (MRE: 67.3% [414\/615]) were performed in 557 IBD patients (CD: 91.4% [509\/557], UC: 8.6% [48\/557]). 38.2% (213\/557) of patients were male, with mean age of 45.6\u00a0years (\u00b115.8), and median disease duration of 11.0\u00a0years (\u00b112.5). Among patients with CD, 33.2% (169\/509) had strictures, with 7.8% having two or more strictures and 66.3% considered inflammatory. A fistula was reported in 10.6% (54\/509), the most common being perianal fistula (27.8% [15\/54]), followed by enterocutaneous fistula (16.8% [9\/54]), and enteroenteric fistula (16.8% [9\/54]). Additionally, 7.4% (41\/557) of patients with IBD were found to have an EIM on cross\u2010sectional imaging, with the most prevalent EIM being cholelithiasis (63.4% [26\/41]), followed by sacroiliitis (24.4% [10\/41]), primary sclerosing cholangitis (4.8% [2\/41]) and nephrolithiasis (4.8% [2\/41]).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Approximately 40% of patients with CD undergoing cross\u2010sectional imaging had evidence of a stricture or fistulizing disease, with 7% of patients with IBD having a detectable EIM. These results highlight the burden of disease and the need for specific therapies for these disease phenotypes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ueg2.12635","type":"journal-article","created":{"date-parts":[[2024,7,29]],"date-time":"2024-07-29T12:50:45Z","timestamp":1722257445000},"page":"870-878","source":"Crossref","is-referenced-by-count":10,"title":["Prevalence of stricturing, penetrating complications and extraintestinal manifestations in inflammatory bowel disease detected on cross\u2010sectional imaging in a tertiary care setting"],"prefix":"10.1002","volume":"12","author":[{"given":"Sudheer Kumar","family":"Vuyyuru","sequence":"first","affiliation":[{"name":"Department of Medicine Division of Gastroenterology Western University Schulich School of Medicine  London Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginia","family":"Solitano","sequence":"additional","affiliation":[{"name":"Department of Medicine Division of Gastroenterology Western University Schulich School of Medicine  London Ontario Canada"},{"name":"Division of Gastroenterology and Gastrointestinal Endoscopy IRCCS Ospedale San Raffaele  Milan Italy"},{"name":"Universit\u00e0 Vita\u2010Salute San Raffaele  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Achuthan","family":"Aruljothy","sequence":"additional","affiliation":[{"name":"Department of Medicine Division of Gastroenterology Western University Schulich School of Medicine  London Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maan","family":"Alkhattabi","sequence":"additional","affiliation":[{"name":"Department of Medicine Faculty of Medicine King Abdulaziz University\u2010 Rabigh Campus  Jeddah Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie","family":"Beaton","sequence":"additional","affiliation":[{"name":"Department of Medicine Division of Gastroenterology Western University Schulich School of Medicine  London Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamie","family":"Gregor","sequence":"additional","affiliation":[{"name":"Department of Medicine Division of Gastroenterology Western University Schulich School of Medicine  London Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahra","family":"Kassam","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging Western University  London Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0350-4947","authenticated-orcid":false,"given":"Harry","family":"Marshall","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging Western University  London Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darryl","family":"Ramsewak","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging Western University  London Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rocio","family":"Sedano","sequence":"additional","affiliation":[{"name":"Department of Medicine Division of Gastroenterology Western University Schulich School of Medicine  London Ontario Canada"},{"name":"Division of Epidemiology and Biostatistics Western University  London Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Sey","sequence":"additional","affiliation":[{"name":"Department of Medicine Division of Gastroenterology Western University Schulich School of Medicine  London Ontario Canada"},{"name":"Lawson Health Research Institute  London Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1092-0033","authenticated-orcid":false,"given":"Vipul","family":"Jairath","sequence":"additional","affiliation":[{"name":"Department of Medicine Division of Gastroenterology Western University Schulich School of Medicine  London Ontario Canada"},{"name":"Division of Epidemiology and Biostatistics Western University  London Ontario Canada"},{"name":"Lawson Health Research Institute  London Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,7,29]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/jcag\/gwy054"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i33.11525"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572\u2010020\u20100156\u20102"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2020.12.031"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.17918"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/s2468\u20101253(19)30173\u20106"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/17474124.2019.1574569"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/2058738419866567"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1148\/rg.2017160121"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.4321\/s1130\u201001082006000700004"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2013.117"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016\u20105085(79)90391\u20103"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572\u20100241.2001.03756.x"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2010.343"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11894\u2010019\u20100698\u20101"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/ibd\/izad061"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2005.082909"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1148\/rg.296095507"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00261\u2010015\u20100357\u20104"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00261\u2010015\u20100361\u20108"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.14853"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1177\/17562848231151293"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2007.09.002"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/00054725\u2010200207000\u201000002"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12093052"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco\u2010jcc\/jjac132"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco\u2010jcc\/jjy154"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco\u2010jcc\/jjx138"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco\u2010jcc\/jjw185"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/ueg2.12314"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/ibd\/izad149"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2016.524"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1873\u20109946(13)60660\u20101"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.13940"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2019.03.040"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl\u20102020\u2010322129"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco\u2010jcc\/jjz095"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2022.108517"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco\u2010jcc\/jjaa260"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/s2468\u20101253(21)00297\u20101"}],"container-title":["United European Gastroenterology Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ueg2.12635","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,30]],"date-time":"2025-11-30T16:01:20Z","timestamp":1764518480000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ueg2.12635"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,29]]},"references-count":40,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2024,9]]}},"alternative-id":["10.1002\/ueg2.12635"],"URL":"https:\/\/doi.org\/10.1002\/ueg2.12635","archive":["Portico"],"relation":{},"ISSN":["2050-6406","2050-6414"],"issn-type":[{"value":"2050-6406","type":"print"},{"value":"2050-6414","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,29]]}}}