{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T01:55:51Z","timestamp":1791856551738,"version":"4.3.4"},"reference-count":95,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,8,6]],"date-time":"2024-08-06T00:00:00Z","timestamp":1722902400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["UEG Journal"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and objective<\/jats:title>\n                    <jats:p>Probiotics show promise in inflammatory bowel disease (IBD), yet knowledge gaps persist. We performed an overview of systematic reviews and an updated metanalysis of randomized controlled trials (RCT) assessing the effect of probiotics on Crohn's disease (CD) and ulcerative colitis (UC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>MEDLINE, Web of Science, and the Cochrane Central Register of Controlled Trials were searched up to September 2023. Primary outcomes were clinical remission and recurrence; secondary outcomes included endoscopic response and remission, and adverse events. We calculated odds ratios (OR) using a random\u2010effects model in R. The quality of systematic reviews was assessed using the AMSTAR\u20102; the trials' risk of bias was evaluated using the Cochrane Collaboration tool. Evidence certainty was rated using the GRADE framework.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Out of 2613 results, 67 studies (22 systematic reviews and 45 RCTs) met the eligibility criteria. In the updated meta\u2010analysis, the OR for clinical remission in UC and CD was 2.00 (95% CI 1.28\u20133.11) and 1.61 (95% CI 0.21\u201312.50), respectively. The subgroup analysis suggested that combining 5\u2010ASA and probiotics may be beneficial for inducing remission in mild\u2010to\u2010moderate UC (OR 2.35, 95% CI 1.29\u20134.28). Probiotics decreased the odds of recurrence in relapsing pouchitis (OR 0.03, 95% CI 0.00\u20130.25) and trended toward reducing clinical recurrence in inactive UC (OR 0.65, 95% CI 0.42\u20131.01). No protective effect against recurrence was identified for CD. Multi\u2010strain formulations appear superior in achieving remission and preventing recurrence in UC. The use of probiotics was not associated with better endoscopic outcomes. Adverse events were similar to control. However, the overall certainty of evidence was low.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Probiotics, particularly multi\u2010strain formulations, appear efficacious for the induction of clinical remission and the prevention of relapse in UC patients as well as for relapsing pouchitis. Notwithstanding, no significant effect was identified for CD. The favorable safety profile of probiotics was also highlighted.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ueg2.12636","type":"journal-article","created":{"date-parts":[[2024,8,6]],"date-time":"2024-08-06T12:44:24Z","timestamp":1722948264000},"page":"960-981","source":"Crossref","is-referenced-by-count":75,"title":["Efficacy and safety of probiotics in IBD: An overview of systematic reviews and updated meta\u2010analysis of randomized controlled trials"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7171-0139","authenticated-orcid":false,"given":"Maria Manuela","family":"Estevinho","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Unidade Local de Sa\u00fade Gaia Espinho (ULSGE)  Vila Nova de Gaia Portugal"},{"name":"Department of Biomedicine Unit of Pharmacology and Therapeutics Faculty of Medicine University of Porto  Porto Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhong","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Medicine London Health Science Center  London Ontario Canada"},{"name":"Division of Gastroenterology Department of Medicine Western University  London Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1133-4578","authenticated-orcid":false,"given":"Iago","family":"Rodr\u00edguez\u2010Lago","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Hospital Universitario de Galdakao Biocruces Bizkaia Health Research Institute Deusto University  Galdakao Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e1rio","family":"Sousa\u2010Pimenta","sequence":"additional","affiliation":[{"name":"Department of Biomedicine Unit of Pharmacology and Therapeutics Faculty of Medicine University of Porto  Porto Portugal"},{"name":"i3S \u2010 Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade Universidade do Porto  Porto Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cl\u00e1udia Camila","family":"Dias","sequence":"additional","affiliation":[{"name":"Knowledge Management Unit Faculty of Medicine University of Porto  Porto Portugal"},{"name":"CINTESIS@RISE Department of Community Medicine Information and Health Decision Sciences (MEDCIDS) Faculty of Medicine of the University of Porto (FMUP)  Porto Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5915-1477","authenticated-orcid":false,"given":"Manuel","family":"Barreiro\u2010de Acosta","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Hospital Cl\u00ednico Universitario de Santiago  Santiago de Compostela Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1092-0033","authenticated-orcid":false,"given":"Vipul","family":"Jairath","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Department of Medicine Western University  London Ontario Canada"},{"name":"Alimentiv, Inc.  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