{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T12:16:16Z","timestamp":1792066576471,"version":"4.4.0"},"reference-count":32,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,8,14]],"date-time":"2024-08-14T00:00:00Z","timestamp":1723593600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Fonden","doi-asserted-by":"publisher","award":["#NNF19OC0057331"],"award-info":[{"award-number":["#NNF19OC0057331"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["UEG Journal"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Since there is no current international consensus on the optimal approach for pain management in acute pancreatitis (AP), analgesic practices may vary across different healthcare settings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study explored global disparities in analgesic use, in particular opioids, during admission and at discharge in hospitalised AP patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a post hoc analysis of the prospective PAINAP database, which included all admissions for AP between April and June 2022 with a 1\u2010month follow\u2010up. Demographic details, analgesic use, and clinical outcomes were recorded during admission and at discharge. Odds ratios (ORs) for opioid use during admission and at discharge were identified using multivariable regression analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Amongst the 1864 patients (52% males, median age 56 (interquartile range, 41\u201371))\u00a0across three different continents, simple analgesics were predominantly used as the primary analgesic (70%). Opioid use during admission was lowest in European centres (67%). Admission in Asian (OR, 2.53 (95% confidence interval (CI), 1.59\u20134.04),\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001), and Australian (OR, 5.81 (95% CI, 3.19\u201310.56),\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001) centres was associated with opioid administration during admission compared with European centres. Increased pain severity, longer pre\u2010admission pain duration, organ failure, and longer length of admission increased opioid use during admission. At discharge, Asian (OR, 2.01 (95% CI, 1.40\u20132.88),\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001) and Australian (OR, 1.91 (95% CI, 1.28\u20132.85),\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.002) centres were associated with opioid prescription compared with European centres. Increased pain severity, longer pre\u2010admission pain duration, acute necrotic collections, and walled\u2010off necrosis also increased the likelihood of opioid prescription at discharge.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>There are substantial intercontinental differences in opioid use for AP pain. Accordingly, there is a need for international guidelines on pain management in AP.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ueg2.12641","type":"journal-article","created":{"date-parts":[[2024,8,14]],"date-time":"2024-08-14T09:07:03Z","timestamp":1723626423000},"page":"1114-1127","source":"Crossref","is-referenced-by-count":16,"title":["Global trends in opioid use for pain management in acute pancreatitis: A multicentre prospective observational study"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8373-1487","authenticated-orcid":false,"given":"Cecilie Siggaard","family":"Knoph","sequence":"first","affiliation":[{"name":"Department of Gastroenterology &amp; Hepatology Centre for Pancreatic Diseases Aalborg University Hospital  Aalborg Denmark"},{"name":"Department of Clinical Medicine Aalborg University  Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Lucocq","sequence":"additional","affiliation":[{"name":"Department of HPB Surgery Royal Infirmary of Edinburgh  Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sivesh Kathir","family":"Kamarajah","sequence":"additional","affiliation":[{"name":"Academic Department of Surgery Institute of Applied Health Research University of Birmingham  Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3916-3168","authenticated-orcid":false,"given":"S\u00f8ren Schou","family":"Olesen","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology &amp; 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Hepatology University of Pittsburgh Medical Centre  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajith K.","family":"Siriwardena","sequence":"additional","affiliation":[{"name":"HBP Unit Manchester Royal Infirmary  Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Windsor","sequence":"additional","affiliation":[{"name":"Surgical and Translational Research Centre University of Auckland  Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asbj\u00f8rn Mohr","family":"Drewes","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology &amp; Hepatology Centre for Pancreatic Diseases Aalborg University Hospital  Aalborg Denmark"},{"name":"Department of Clinical Medicine Aalborg University  Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manu","family":"Nayar","sequence":"additional","affiliation":[{"name":"HPB and Transplant Unit Freeman Hospital  Newcastle upon Tyne UK"},{"name":"Population Health Sciences Institute Newcastle University  Newcastle Upon Tyne UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"PAINAP Collaborative","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3099-2197","authenticated-orcid":false,"given":"Sanjay","family":"Pandanaboyana","sequence":"additional","affiliation":[{"name":"HPB and Transplant Unit Freeman Hospital  Newcastle upon Tyne UK"},{"name":"Population Health Sciences Institute Newcastle University  Newcastle Upon Tyne UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,8,14]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2021.09.043"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265\u2010022\u201001766\u20104"},{"issue":"4","key":"e_1_2_12_4_1","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1016\/j.pan.2013.07.063","article-title":"IAP\/APA evidence\u2010based guidelines for the management of acute pancreatitis","volume":"13","author":"Working Group IAP\/APA Acute Pancreatitis Guidelines","year":"2013","journal-title":"Pancreatology"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/jhbp.259"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268\u2010021\u201006420\u2010w"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2019.1827"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.2105\/ajph.2018.304753"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/mog.0000000000000861"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2019.1834"},{"key":"e_1_2_12_11_1","article-title":"Opioid analgesia and severity of acute pancreatitis: an international multicentre cohort study on pain management in acute pancreatitis","volume":"4","author":"Pandanaboyana S","year":"2024","journal-title":"United Eur Gastroenterol J"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2019.11.017"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/mpa.0000000000002160"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/mpa.0000000000002180"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl\u20102012\u2010302779"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2014.11.025"},{"issue":"6","key":"e_1_2_12_17_1","first-page":"514","article-title":"Is the WHO analgesic ladder still valid? 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